公开(公告)号：EP1749011A1

公开(公告)日：2007-02-07

申请号：EP05750075.3

申请日：2005-05-12

申请人： Bristol-Myers Squibb Company

发明人： NAIDU, B. Narasimhulu ,  BANVILLE, Jacques ,  BEAULIEU, Francis ,  CONNOLLY, Timothy P. ,  KRYSTAL, Mark R. ,  MATISKELLA, John D. ,  OUELLET, Carl ,  PLAMONDON, Serge ,  REMILLARD, Roger ,  SORENSON, Margaret E. ,  UEDA, Yasutsugu ,  WALKER, Michael A.

IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P31/18 ,  C07D263/00 ,  C07D239/00 ,  C07D265/00 ,  C07D267/00

CPC分类号： C07D498/04

摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

摘要翻译： 本发明包括式I的一系列环状双环嘧啶酮化合物，其抑制HIV整合酶并防止病毒整合入人DNA。 这一行动使这些化合物可用于治疗艾滋病毒感染和艾滋病。 本发明还包括用于治疗感染HIV的药物组合物和方法。

公开(公告)号：EP1948621A1

公开(公告)日：2008-07-30

申请号：EP06837693.8

申请日：2006-11-15

申请人： Bristol-Myers Squibb Company

发明人： NAIDU, B. Narasimhulu ,  SORENSON, Margaret E. ,  UEDA, Yasutsugu ,  MATISKELLA, John D. ,  WALKER, Michael A.

IPC分类号： C07D239/70 ,  C07D498/04 ,  C07D498/20 ,  A61K31/5383 ,  A61K31/5386 ,  A61P31/12

CPC分类号： C07D487/02 ,  C07D239/70

摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

公开(公告)号：EP2649077A1

公开(公告)日：2013-10-16

申请号：EP11806028.4

申请日：2011-12-08

申请人： Bristol-Myers Squibb Company

发明人： UEDA, Yasutsugu ,  CONNOLLY, Timothy P. ,  JOHNSON, Barry L. ,  LI, Chen ,  NAIDU, B. Narasimhulu ,  PATEL, Manoj ,  PEESE, Kevin ,  SORENSON, Margaret E. ,  WALKER, Michael A. ,  BOWSHER, Michael S. ,  LI, Rongti

IPC分类号： C07D487/08 ,  C07D519/00 ,  A61K31/55 ,  A61P31/18

CPC分类号： C07D487/08 ,  C07D519/00

摘要： The disclosure generally relates to the novel compounds of formula (I), including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

公开(公告)号：EP1749011B1

公开(公告)日：2008-10-29

申请号：EP05750075.3

申请日：2005-05-12

申请人： Bristol-Myers Squibb Company

发明人： NAIDU, B. Narasimhulu ,  BANVILLE, Jacques ,  BEAULIEU, Francis ,  CONNOLLY, Timothy P. ,  KRYSTAL, Mark R. ,  MATISKELLA, John D. ,  OUELLET, Carl ,  PLAMONDON, Serge ,  REMILLARD, Roger ,  SORENSON, Margaret E. ,  UEDA, Yasutsugu ,  WALKER, Michael A.

IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P31/18

CPC分类号： C07D498/04

摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

公开(公告)号：EP1756069A2

公开(公告)日：2007-02-28

申请号：EP05749460.1

申请日：2005-05-13

申请人： Bristol-Myers Squibb Company

发明人： NAIDU, B. Narasimhulu ,  SORENSON, Margaret E.

IPC分类号： C07D239/545 ,  C07D403/04 ,  C07D471/10

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D471/10 ,  C07D491/10

摘要： Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating HIV infection and AIDS.

摘要翻译： 本公开的化合物是螺环取代的嘧啶甲酰胺。 还公开了包含这些化合物的药物组合物，以及使用这些化合物的方法。 这些化合物可用于治疗HIV感染和AIDS。