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公开(公告)号：EP1749011B1
公开(公告)日：2008-10-29
申请号：EP05750075.3
申请日：2005-05-12
发明人： NAIDU, B. Narasimhulu , BANVILLE, Jacques , BEAULIEU, Francis , CONNOLLY, Timothy P. , KRYSTAL, Mark R. , MATISKELLA, John D. , OUELLET, Carl , PLAMONDON, Serge , REMILLARD, Roger , SORENSON, Margaret E. , UEDA, Yasutsugu , WALKER, Michael A.
IPC分类号： C07D498/04 , A61K31/519 , A61P31/18
CPC分类号： C07D498/04
摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
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公开(公告)号：EP2280981A1
公开(公告)日：2011-02-09
申请号：EP09722517.1
申请日：2009-03-19
发明人： BEAULIEU, Francis , OUELLET, Carl , NAIDU, B., Narasimhulu , PATEL, Manoj , UEDA, Yasutsugu , CONNOLLY, Timothy, P. , WEISS, Jonathan, R. , WALKER, Michael, A. , MEANWELL, Nicholas, A. , PEESE, Kevin, M. , SORENSON, Margaret, E. , LI, Chen
IPC分类号： C07D498/18 , A61K31/5386 , C07D471/18 , A61K31/529 , C07D487/08 , A61K31/55 , C07D471/08 , A61P31/18 , C07D493/18
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV. Formule (I).
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公开(公告)号：EP1948666A1
公开(公告)日：2008-07-30
申请号：EP06837651.6
申请日：2006-11-15
发明人： NAIDU, B. Narasimhulu , UEDA, Yasutsugu , MATISKELLA, John D. , WALKER, Michael A. , BANVILLE, Jacques , BEAULIEU, Francis , OUELLET, Carl , PLAMONDON, Serge
IPC分类号： C07D498/10 , C07D498/20 , A61K31/553 , A61P31/18
CPC分类号： C07D498/04 , C07D498/10 , C07D498/20
摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV. [I]
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4.发明公开AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权氨基取代的四环化合物其是作为抗炎剂是有用的，以及含有它们的药品。
公开(公告)号：EP1325009A2
公开(公告)日：2003-07-09
申请号：EP01979911.3
申请日：2001-09-27
发明人： BEAULIEU, Francis , OUELLET, Carl , BELEMA, Makonen , QIU, Yuping , YANG, Xuejie , ZUSI, Fred, C.
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/437 , A61K31/4365 , A61P29/00 , A61P37/00 , C07D471/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D513/04 , Y02A50/411
摘要： Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y 1 , Y 2 , and R 2- 4 are as defined in the specification.
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5.发明授权THIOPHENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权三环类化合物对THIOPHENGRUNDLAGE和药物组合物含
公开(公告)号：EP1490371B1
公开(公告)日：2007-08-15
申请号：EP03718092.4
申请日：2003-03-27
发明人： BELEMA, Makonen , BUNKER, Amy , NGUYEN, Van , BEAULIEU, Francis , OUELLET, Carl , MARINIER, Anne , ROY, Stephan , YANG, Xuejie , QIU, Yuping , ZHANG, Yunhui , MARTEL, Alain , ZUSI, Christopher
IPC分类号： C07D495/14 , A61K31/4985 , A61P9/00
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
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公开(公告)号：EP1749011A1
公开(公告)日：2007-02-07
申请号：EP05750075.3
申请日：2005-05-12
发明人： NAIDU, B. Narasimhulu , BANVILLE, Jacques , BEAULIEU, Francis , CONNOLLY, Timothy P. , KRYSTAL, Mark R. , MATISKELLA, John D. , OUELLET, Carl , PLAMONDON, Serge , REMILLARD, Roger , SORENSON, Margaret E. , UEDA, Yasutsugu , WALKER, Michael A.
IPC分类号： C07D498/04 , A61K31/519 , A61P31/18 , C07D263/00 , C07D239/00 , C07D265/00 , C07D267/00
CPC分类号： C07D498/04
摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括式I的一系列环状双环嘧啶酮化合物，其抑制HIV整合酶并防止病毒整合入人DNA。 这一行动使这些化合物可用于治疗艾滋病毒感染和艾滋病。 本发明还包括用于治疗感染HIV的药物组合物和方法。
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7.发明公开THIOPENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权三环类化合物对THIOPHENGRUNDLAGE和药物组合物含
公开(公告)号：EP1490371A1
公开(公告)日：2004-12-29
申请号：EP03718092.4
申请日：2003-03-27
发明人： BELEMA, Makonen , BUNKER, Amy , NGUYEN, Van , BEAULIEU, Francis , OUELLET, Carl , MARINIER, Anne , ROY, Stephan , YANG, Xuejie , QIU, Yuping , ZHANG, Yunhui , MARTEL, Alain , ZUSI, Christopher
IPC分类号： C07D487/04 , C07D487/14 , C07D487/20
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
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公开(公告)号：EP1326875A2
公开(公告)日：2003-07-16
申请号：EP01979918.8
申请日：2001-09-28
IPC分类号： C07H17/02 , A61K31/7056 , A61P35/00
CPC分类号： C07H19/23 , A61K31/7056
摘要： The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
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公开(公告)号：EP2280981B8
公开(公告)日：2014-09-17
申请号：EP09722517.1
申请日：2009-03-19
发明人： BEAULIEU, Francis , OUELLET, Carl , NAIDU, B., Narasimhulu , PATEL, Manoj , UEDA, Yasutsugu , CONNOLLY, Timothy, P. , WEISS, Jonathan, R. , WALKER, Michael, A. , MEANWELL, Nicholas, A. , PEESE, Kevin, M. , SORENSON, Margaret, E. , LI, Chen
IPC分类号： C07D498/18 , A61K31/5386 , C07D471/18 , A61K31/529 , C07D487/08 , A61K31/55 , C07D471/08 , A61P31/18 , C07D493/18
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
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公开(公告)号：EP2280981B1
公开(公告)日：2014-04-23
申请号：EP09722517.1
申请日：2009-03-19
发明人： BEAULIEU, Francis , OUELLET, Carl , NAIDU, B., Narasimhulu , PATEL, Manoj , UEDA, Yasutsugu , CONNOLLY, Timothy, P. , WEISS, Jonathan, R. , WALKER, Michael, A. , MEANWELL, Nicholas, A. , PEESE, Kevin, M. , SORENSON, Margaret, E. , LI, Chen
IPC分类号： C07D498/18 , A61K31/5386 , C07D471/18 , A61K31/529 , C07D487/08 , A61K31/55 , C07D471/08 , A61P31/18 , C07D493/18
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
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