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公开(公告)号：EP0515927A3
公开(公告)日：1992-12-23
申请号：EP92108232.7
申请日：1992-05-15
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244 , C12P19/56
摘要： Pradimicin S of the formula
in which R a is hydrogen or hydroxy and R b is hydrogen, having antifungal and antiviral activity is prepared by cultivation of Actinomadura sp. AA0851 in a nutrient medium containing assimilable sources of carbon and nitrogen.-
公开(公告)号：EP0407939A1
公开(公告)日：1991-01-16
申请号：EP90113085.6
申请日：1990-07-09
CPC分类号： C12P1/06 , C12R1/01 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A 2 , A3, D 1 , D 2 and D 3 , by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过发酵新型微生物副杆菌ATCC-53884的BU-3889V生产菌株生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V，并将其分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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公开(公告)号：EP0472005A1
公开(公告)日：1992-02-26
申请号：EP91112612.6
申请日：1991-07-26
CPC分类号： C07H19/01 , C07H15/26 , Y10S435/822
摘要： A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B 1 , B 2 , and C. The components BU-4224V B 1 and B 2 (I) display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
摘要翻译： 一种名为BU-4224V的新型抗生素复合物，由Kibdelosporangium albatum sp。 十一月 菌株R761-7。 复合物可以色谱分离成为命名为BU-4224V A，B1，B2和C的生物活性组分。组分BU-4224V B1和B2（I）显示抗病毒和抗微生物活性，而组分BU-4224V A具有抗微生物活性， 组分BU-4224V C具有抗病毒活性。
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公开(公告)号：EP0603030A3
公开(公告)日：1995-06-28
申请号：EP93402976.0
申请日：1993-12-09
发明人： Tenmyo, Osamu , Nishio, Maki , Ikede, Chiharu
摘要： There is provided a new antiviral antibiotic designated herein as BU-4628V which is produced by fermentation of a BU-4628V-producing strain of a new microorganism, Streptomyces sp. ATCC 55286. Antibiotic BU-4628V is recovered and purified from the fermentation broth by use of extraction and chromatography techniques. BU-4628V has bean found to have some antibacterial activity and inhibits the growth of HIV and HSV viruses.
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5.发明公开Antiviral antibiotic BU-4628V and preparation thereof 失效Antivirales Antibiotikum BU-4628V und dessen Herstellung。
公开(公告)号：EP0603030A2
公开(公告)日：1994-06-22
申请号：EP93402976.0
申请日：1993-12-09
发明人： Tenmyo, Osamu , Nishio, Maki , Ikede, Chiharu
摘要： There is provided a new antiviral antibiotic designated herein as BU-4628V which is produced by fermentation of a BU-4628V-producing strain of a new microorganism, Streptomyces sp. ATCC 55286.
Antibiotic BU-4628V is recovered and purified from the fermentation broth by use of extraction and chromatography techniques. BU-4628V has bean found to have some antibacterial activity and inhibits the growth of HIV and HSV viruses.摘要翻译： 提供了一种本文中称为BU-4628V的新的抗病毒抗生素，其通过发酵新型微生物链霉菌（Streptomyces sp。）的BU-4628V产生菌株产生。 ATCC 55286.通过使用提取和色谱技术从发酵液中回收和纯化抗生素BU-4628V。 BU-4628V具有发现具有一些抗菌活性并抑制HIV和HSV病毒生长的豆。
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公开(公告)号：EP0560149A1
公开(公告)日：1993-09-15
申请号：EP93103131.4
申请日：1993-02-26
发明人： Tenmyo, Osamu , Sawadea, Yosuke , Oki, Toshikazu , Oka, Masahisa , Sugawara, Masaru , Ohkusa, Noriyuki , Lin, Pin-Fang , Mamber, Stephen W.
IPC分类号： C07C49/733 , A61K31/12 , C12P7/38 , C12N1/16
CPC分类号： C12R1/645 , C07C49/733 , C12P7/38
摘要： Compound of the formula
useful in treating cancer, and viral or bacterial infections.摘要翻译： 用于治疗癌症的化学式
，以及病毒或细菌感染。 [R -
公开(公告)号：EP0515927A2
公开(公告)日：1992-12-02
申请号：EP92108232.7
申请日：1992-05-15
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244 , C12P19/56
摘要： Pradimicin S of the formula
in which R a is hydrogen or hydroxy and R b is hydrogen, having antifungal and antiviral activity is prepared by cultivation of Actinomadura sp. AA0851 in a nutrient medium containing assimilable sources of carbon and nitrogen.摘要翻译： 其中R a是氢或羟基，R b是具有抗真菌和抗病毒活性的氢的式CHEM的Pradimicin S通过培养Actinomadura sp。 AA0851在含有可吸收碳源和氮源的营养培养基中。
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