公开(公告)号：EP1409463A1

公开(公告)日：2004-04-21

申请号：EP02739978.1

申请日：2002-06-25

申请人： Bristol-Myers Squibb Company ,  PHARMACOPEIA, INC.

发明人： MORIARTY, Kevin, J. ,  SHIMSHOCK, Yvonne ,  AHMED, Gulzar ,  WU, Junjun ,  WEN, James ,  LI, Wei ,  ERICKSON, Shawn, D. ,  LETOURNEAU, Jeffrey, J. ,  MCDONALD, Edward ,  LEFTHERIS, Katerina ,  WROBLESKI, Stephen, T. ,  HUSSAIN, Zahid ,  HENDERSON, Ian ,  METZGER, Axel ,  BALDWIN, John, J. ,  DYCKMAN, Alaric

IPC分类号： C07D239/32 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D251/46 ,  C07D251/52 ,  C07D251/54 ,  A61K31/166 ,  A61P29/00 ,  A61P37/08 ,  A61P7/02

摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-a expression utilizing compounds of the present invention are also disclosed.

摘要翻译： 公开了通过抑制p38激酶阻断细胞因子产生的N-杂环化合物。 在一个实施方案中，本发明的化合物由式（I）表示。 也公开了使用本发明化合物治疗与不适当的p38激酶活性或TNF-α表达有关的病症的方法，药物组合物和方法。

公开(公告)号：EP1409463B1

公开(公告)日：2010-02-24

申请号：EP02739978.1

申请日：2002-06-25

申请人： Bristol-Myers Squibb Company ,  PHARMACOPEIA, INC.

发明人： MORIARTY, Kevin, J. ,  SHIMSHOCK, Yvonne ,  AHMED, Gulzar ,  WU, Junjun ,  WEN, James ,  LI, Wei ,  ERICKSON, Shawn, D. ,  LETOURNEAU, Jeffrey, J. ,  MCDONALD, Edward ,  LEFTHERIS, Katerina ,  WROBLESKI, Stephen, T. ,  HUSSAIN, Zahid ,  HENDERSON, Ian ,  METZGER, Axel ,  BALDWIN, John, J. ,  DYCKMAN, Alaric

IPC分类号： C07D239/32 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D251/46 ,  C07D251/52 ,  C07D251/54 ,  A61K31/166 ,  A61P29/00 ,  A61P37/08 ,  A61P7/02

公开(公告)号：EP1242385B1

公开(公告)日：2009-11-25

申请号：EP00988358.8

申请日：2000-12-22

申请人： PHARMACOPEIA, INC. ,  Bristol-Myers Squibb Company

发明人： MORIARTY, Kevin, Joseph ,  SHIMSHOCK, Yvonne ,  AHMED, Gulzar ,  WU, Junjun ,  WEN, James ,  LI, Wei ,  ERICKSON, Shawn, David ,  LETOURNEAU, Jeffrey, John ,  MCDONALD, Edward ,  LEFTHERIS, Katerina ,  WROBLESKI, Stephen, T. ,  HUSSAIN, Zahid

IPC分类号： C07D237/04 ,  A61K31/505 ,  A61P29/00 ,  C07D401/12 ,  A61K31/53 ,  C07D403/04 ,  A61K31/55 ,  C07D403/12

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D251/52 ,  C07D251/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I. Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

公开(公告)号：EP1242385A1

公开(公告)日：2002-09-25

申请号：EP00988358.8

申请日：2000-12-22

申请人： PHARMACOPEIA, INC. ,  Bristol-Myers Squibb Co.

发明人： MORIARTY, Kevin, Joseph ,  SHIMSHOCK, Yvonne ,  AHMED, Gulzar ,  WU, Junjun ,  WEN, James ,  LI, Wei ,  ERICKSON, Shawn, David ,  LETOURNEAU, Jeffrey, John ,  MCDONALD, Edward ,  LEFTHERIS, Katerina ,  WROBLESKI, Stephen, T. ,  HUSSAIN, Zahid

IPC分类号： C07D237/04 ,  A61K31/505 ,  A61P29/00 ,  C07D401/12 ,  A61K31/53 ,  C07D403/04 ,  A61K31/55 ,  C07D403/12

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D251/52 ,  C07D251/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I. Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.