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1.发明公开BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA 有权作为基质金属蛋白酶和TNF-α抑制剂的β氨基酸衍生物
公开(公告)号：EP1263756A2
公开(公告)日：2002-12-11
申请号：EP01924171.0
申请日：2001-03-15
发明人： DUAN, Jingwu , KING, Bryan, W. , DECICCO, Carl , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E.
IPC分类号： C07D401/12 , C07D211/34 , C07D215/14 , C07D417/12 , C07D405/12 , C07D401/06 , C07D401/14 , C07D211/58 , C07D409/12 , C07D405/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D401/06 , C07D211/34 , C07D211/58 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present application describes novel β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, U?a, Xa, Ya, Za, R1, R2, R3, R4, and R4a¿ are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
摘要翻译： 本申请描述了式（I）的新型β-氨基酸衍生物或其药学上可接受的盐或前药形式，其中A，X，Z，Uαa，Xa，Ya，Za，R1，R2，R3，R4和 R4a在本说明书中定义，其可用作金属蛋白酶和TNF-α抑制剂。
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2.发明公开
公开(公告)号：EP1322627A1
公开(公告)日：2003-07-02
申请号：EP01977390.2
申请日：2001-10-03
IPC分类号： C07D275/03 , C07D279/02 , C07D417/10 , C07D417/12 , C07D409/12 , A61K31/425 , A61K31/4439 , A61K31/54 , A61K31/444 , A61K31/4709 , A61K31/433 , A61P29/00
CPC分类号： C07D275/03 , C07D279/02 , C07D409/12 , C07D417/10 , C07D417/12
摘要： The present application describes novel cyclic sulfonyl derivatives of formula (I) particularly of formulae (II), (III), (IV) and (V) which are useful as metalloprotease inhibitors.
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3.发明授权BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA 有权BETA阿明酸衍生物FOR USE AS MATRIX METALLOPROTEASEN-和TNA ALPHA抑制剂
公开(公告)号：EP1263756B1
公开(公告)日：2004-02-25
申请号：EP01924171.0
申请日：2001-03-15
发明人： DUAN, Jingwu , KING, Bryan, W. , DECICCO, Carl , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E.
IPC分类号： C07D401/12 , C07D211/34 , C07D215/14 , C07D417/12 , C07D405/12 , C07D401/06 , C07D401/14 , C07D211/58 , C07D409/12 , C07D405/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D401/06 , C07D211/34 , C07D211/58 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present application describes novel β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, U?a, Xa, Ya, Za, R1, R2, R3, R4, and R4a¿ are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
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