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1.发明公开ESTER DERIVATIVES OF ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE 审中-公开FOR USE雄激素和方法的酯衍生物
公开(公告)号：EP2994451A1
公开(公告)日：2016-03-16
申请号：EP14793978.9
申请日：2014-05-09
发明人： MAWJI, Nasrin R. , WANG, Jun , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , SADAR, Marianne Dorothy
CPC分类号： C07C69/63 , A61K31/222 , A61K45/06 , A61K2300/00
摘要： Compounds having a structure of Structure I or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 , J
1 , J
2 , X, Z, n
1 and n
2 are as defined herein, and wherein at least one of R
1 , R
2 or R
3 is an alkyl, alkenyl, aryl or aralkyl ester, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.-
2.发明公开HETEROCYCLIC COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE 审中-公开用于癌症成像和治疗的杂环化合物及其使用方法
公开(公告)号：EP3245193A1
公开(公告)日：2017-11-22
申请号：EP16736999.0
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07D249/04 , A61K31/4164 , A61K31/4192 , A61K31/495 , A61K51/04 , A61P35/00 , C07D233/64 , C07D295/088
CPC分类号： A61K45/06 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/0453 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61P35/00 , C07B59/002 , C07D233/60 , C07D249/04 , C07D265/30 , C07D295/088
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：EP4446301A2
公开(公告)日：2024-10-16
申请号：EP24184079.2
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07B59/00
摘要： Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.-
公开(公告)号：EP3988541A1
公开(公告)日：2022-04-27
申请号：EP21212648.6
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07D233/60 , C07D249/04 , C07D265/30 , C07D295/088 , A61K31/4164 , A61K31/4192 , A61K31/495 , A61K51/04 , A61P35/00 , A61K31/5375 , C07B59/00
摘要： Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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