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1.发明公开HALOGENATED COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE 审中-公开卤素化合物为使用治疗癌症成像和治疗及方法
公开(公告)号：EP3044197A1
公开(公告)日：2016-07-20
申请号：EP14843037.4
申请日：2014-09-09
发明人： ANDERSEN, Raymond John , GARCIA FERNANDEZ, Javier , JIAN, Kunzhong , SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , WANG, Jun , IMAMURA, Yusuke
CPC分类号： A61K51/04 , A61K31/09 , A61K31/167 , A61K31/225 , A61K31/275 , A61K31/4166 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C43/23 , C07C57/58 , C07C69/63 , A61K2300/00
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.
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2.发明公开BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS 有权双酚衍生物及其作为ANDROGENREZEPTORAKTIVITÄTSMODULATOREN使用
公开(公告)号：EP2521707A1
公开(公告)日：2012-11-14
申请号：EP11731645.5
申请日：2011-01-06
发明人： SADAR, Marianne D. , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond J. , GARCIA FERNANDEZ, Javier
CPC分类号： C07C57/38 , A61K31/09 , A61K31/22 , C07C15/16 , C07C43/225 , C07C43/23 , C07C69/63 , C07D401/06
摘要： This invention provides bisphenol derivatives having a structure of formula I. Said compounds are modulators of the androgen receptor activity and are useful in the treatment of various diseases, including prostate cancer, breast cancer, ovarian cancer, endometrial cancer, acne, ovarian cysts, polycystic ovarian disease, age-related macular degeneration, precocious puberty, hirsutism and air loss.
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3.发明公开HETEROCYCLIC COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE 审中-公开用于癌症成像和治疗的杂环化合物及其使用方法
公开(公告)号：EP3245193A1
公开(公告)日：2017-11-22
申请号：EP16736999.0
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07D249/04 , A61K31/4164 , A61K31/4192 , A61K31/495 , A61K51/04 , A61P35/00 , C07D233/64 , C07D295/088
CPC分类号： A61K45/06 , A61K31/4164 , A61K31/4192 , A61K31/5375 , A61K51/0453 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61P35/00 , C07B59/002 , C07D233/60 , C07D249/04 , C07D265/30 , C07D295/088
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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公开(公告)号：EP3442942A1
公开(公告)日：2019-02-20
申请号：EP17781660.0
申请日：2017-04-18
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： ANDERSEN, Raymond , SADAR, Marianne Dorothy , JlAN, Kunzhong , MAWJl, Nasrin R. , WANG, Jun , BANUELOS, Carmen Adriana , YANG, Yu-Chi
IPC分类号： C07C317/16 , A61K31/09 , A61K31/10 , A61K31/165 , A61K31/222 , A61K31/4164 , A61P35/00 , C07C311/04 , C07C317/22 , C07C43/23 , C07D233/60 , C07D295/088
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5.发明授权BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS 有权联合国海峡两岸知识产权组织安哥拉经济和社会理事会
公开(公告)号：EP2521707B1
公开(公告)日：2017-06-14
申请号：EP11731645.5
申请日：2011-01-06
发明人： SADAR, Marianne D. , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond J. , GARCIA FERNANDEZ, Javier
IPC分类号： C07C15/16 , C07C43/225 , C07C43/23 , C07C57/38 , C07C69/63 , C07D401/06 , A61K31/09 , A61K31/22 , A61P35/00
CPC分类号： C07C57/38 , A61K31/09 , A61K31/22 , C07C15/16 , C07C43/225 , C07C43/23 , C07C69/63 , C07D401/06
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6.发明公开ESTER DERIVATIVES OF ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE 审中-公开FOR USE雄激素和方法的酯衍生物
公开(公告)号：EP2994451A1
公开(公告)日：2016-03-16
申请号：EP14793978.9
申请日：2014-05-09
发明人： MAWJI, Nasrin R. , WANG, Jun , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , SADAR, Marianne Dorothy
CPC分类号： C07C69/63 , A61K31/222 , A61K45/06 , A61K2300/00
摘要： Compounds having a structure of Structure I or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 , J
1 , J
2 , X, Z, n
1 and n
2 are as defined herein, and wherein at least one of R
1 , R
2 or R
3 is an alkyl, alkenyl, aryl or aralkyl ester, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.-
公开(公告)号：EP4446301A2
公开(公告)日：2024-10-16
申请号：EP24184079.2
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07B59/00
摘要： Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.-
公开(公告)号：EP3988541A1
公开(公告)日：2022-04-27
申请号：EP21212648.6
申请日：2016-01-13
申请人： British Columbia Cancer Agency Branch , The University of British Columbia University-Industry Liaison Office
发明人： SADAR, Marianne Dorothy , MAWJI, Nasrin R. , BANUELOS, Carmen Adriana , ANDERSEN, Raymond John , FERNANDEZ, Javier Garcia , JIAN, Kunzhong
IPC分类号： C07D233/60 , C07D249/04 , C07D265/30 , C07D295/088 , A61K31/4164 , A61K31/4192 , A61K31/495 , A61K51/04 , A61P35/00 , A61K31/5375 , C07B59/00
摘要： Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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