公开(公告)号：EP3185276A1

公开(公告)日：2017-06-28

申请号：EP16195564.6

申请日：2016-10-25

Applicant: Bruker Daltonics, Inc.

Inventor： Kaplan, Desmond Allen ,  Muntean, Felician ,  Park, Mel ,  Ridgeway, Mark

IPC: H01J49/06 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/4225 ,  G01N27/622 ,  H01J49/0045 ,  H01J49/066 ,  H01J49/10

Abstract: The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer ("TIMS") is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

Abstract translation: 本发明提供了一种用于获取复杂物质混合物中物质的碎片离子谱的方法，其中捕获的离子迁移谱仪（“TIMS”）被用作耦合到三重四极杆质量过滤器组件的离子迁移率分离装置。 碎片离子谱可以用于在具有上游物质分离器的质谱仪中通过碎片离子质谱来鉴定复杂混合物中的大量蛋白质，或用于安全定量某些物质。 TIMS，特别是配备了平行积累，提供了独特的可能性，以延长离子积累时间，以找到更多可检测的离子种类，而不会降低碎片离子质谱的测量能力。 碎片离子质谱的高测量容量允许重复测量低丰度离子种类以提高碎片离子谱的质量。

公开(公告)号：EP3032569B1

公开(公告)日：2018-10-17

申请号：EP15195298.3

申请日：2015-11-19

Applicant: Bruker Daltonics, Inc.

Inventor： Kaplan, Desmond Allen ,  Muntean, Felician ,  Zanon, Stephen

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/421

Abstract: The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.

公开(公告)号：EP3032569A1

公开(公告)日：2016-06-15

申请号：EP15195298.3

申请日：2015-11-19

Applicant: Bruker Daltonics, Inc.

Inventor： Kaplan, Desmond Allen ,  Muntean, Felician ,  Zanon, Stephen

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/421

Abstract: The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.

Abstract translation: 本发明涉及一种用于质谱分析的射频离子导向结构，其通过允许由RF限制场所排斥的离子飞过和离开离子导向电极并使其不受打击敏感电位限定表面的影响而使污染最小化 离子导向电极。 在离子导向器的入口端处，多个电极的每个电极具有分叉的前端或包含面向离子导向件内部的凹陷特征。 对于分叉的电极，叉形端部的齿可以具有不同的形状或锥度，并且可以使用导电网来覆盖齿之间的间隙。 类似地，对于具有凹陷特征的电极，导电网可以覆盖凹陷特征。