公开(公告)号：EP2978008B1

公开(公告)日：2018-10-03

申请号：EP15175379.5

申请日：2015-07-06

Applicant: Bruker Daltonics, Inc.

Inventor： Moeller, Roy P. ,  Muntean, Felician ,  Splendore, Maurizio

IPC: H01J27/20 ,  H01J49/14

CPC classification number: H01J49/147 ,  H01J27/205

Abstract: The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.

公开(公告)号：EP3239705A1

公开(公告)日：2017-11-01

申请号：EP17156393.5

申请日：2017-02-16

Applicant: Bruker Daltonics, Inc.

Inventor： Silveira, Joshua

IPC: G01N27/62

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/062

Abstract: The invention relates to methods and instruments for combined separation of ions according to mobility and mass to charge ratio. The mass spectrometric system comprises an ion source, a mobility separator and a mass analyzer wherein the mobility separator comprises (i) a gas filled drift region with a substantially constant electric DC field or a traveling electric field and (ii) an ion storage located adjacent to the entrance or inside the drift region. The ion storage comprises an electric field gradient and a gas flow wherein the electric field gradient and gas flow provide opposing forces on ions in the ion storage such that they are trapped at mobility dependent positions inside the ion storage.

Abstract translation: 本发明涉及根据迁移率和质荷比组合分离离子的方法和仪器。 质谱系统包括离子源，迁移率分离器和质量分析器，其中迁移率分离器包括（i）具有基本恒定的直流电场或行进电场的充气漂移区和（ii）位于相邻的离子存储器 到入口或漂移区域内。 离子存储器包括电场梯度和气体流，其中电场梯度和气体流提供离子存储器中离子的相反力，使得它们被捕获在离子存储器内的迁移率依赖位置处。

公开(公告)号：EP3185276A1

公开(公告)日：2017-06-28

申请号：EP16195564.6

申请日：2016-10-25

Applicant: Bruker Daltonics, Inc.

Inventor： Kaplan, Desmond Allen ,  Muntean, Felician ,  Park, Mel ,  Ridgeway, Mark

IPC: H01J49/06 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/4225 ,  G01N27/622 ,  H01J49/0045 ,  H01J49/066 ,  H01J49/10

Abstract: The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer ("TIMS") is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

Abstract translation: 本发明提供了一种用于获取复杂物质混合物中物质的碎片离子谱的方法，其中捕获的离子迁移谱仪（“TIMS”）被用作耦合到三重四极杆质量过滤器组件的离子迁移率分离装置。 碎片离子谱可以用于在具有上游物质分离器的质谱仪中通过碎片离子质谱来鉴定复杂混合物中的大量蛋白质，或用于安全定量某些物质。 TIMS，特别是配备了平行积累，提供了独特的可能性，以延长离子积累时间，以找到更多可检测的离子种类，而不会降低碎片离子质谱的测量能力。 碎片离子质谱的高测量容量允许重复测量低丰度离子种类以提高碎片离子谱的质量。

公开(公告)号：EP3029713A1

公开(公告)日：2016-06-08

申请号：EP15195084.7

申请日：2015-11-18

Applicant: Bruker Daltonics, Inc.

Inventor： Splendore, Maurizio ,  Zanon, Stephen

IPC: H01J49/04

CPC classification number: H01J49/24 ,  H01J49/04 ,  H01J49/165

Abstract: The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed. The interface comprises a wall dividing the ion source region and the vacuum region and has a central orifice formed therein for letting pass gaseous and particulate matter from the ion source region into the vacuum region following the pressure gradient, wherein the central orifice is surrounded at least section-wise by a plurality of lateral orifices.

Abstract translation: 本发明涉及一种质谱仪，其具有基本上大气压的离子源区域，其中离子由液体样品形成。 质谱仪还具有用于将形成的离子从离子源区域传输到保持在基本上低于大气压力的压力水平并且形成的离子被进一步处理的真空区域的界面。 界面包括分隔离子源区域和真空区域的壁，并且具有形成在其中的中心孔口，用于使气态和颗粒物质从离子源区域传递到跟随压力梯度的真空区域中，其中中心孔口至少被包围 通过多个侧向孔分段。

公开(公告)号：EP2715776A2

公开(公告)日：2014-04-09

申请号：EP12792888.5

申请日：2012-06-02

Applicant: Bruker Daltonics, Inc.

Inventor： PARK, Melvin

IPC: H01J49/26

CPC classification number: H01J49/421 ,  H01J49/063

Abstract: An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can be used to excite ions into secular motion, inductively detect the ions, and thereby generate a mass spectrum.

公开(公告)号：EP2688087A2

公开(公告)日：2014-01-22

申请号：EP13003393.9

申请日：2013-07-04

Applicant: Bruker Daltonics, Inc.

Inventor： Moeller, Roy P. ,  Thakur, Rohan ,  Muntean, Felician ,  Splendore, Maurizio A. ,  Zanon, Stephen

IPC: H01J49/16

CPC classification number: H01J49/10 ,  H01J49/165 ,  H01J49/167

Abstract: An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.

Abstract translation: 用于电喷雾离子源的组件包括毛细管，用于引导通常含有目标分析物的液体流，所述分析物将被电喷雾到电离室中，第一管至少部分地包封毛细管，使得第一 在毛细管附近产生用于引导第一可加热气体的导管，以及具有内部抽真空空间并位于毛细管外周的中空构件，使得从毛细管附近流过的第一可加热气体到液体中的热传递 毛细管受阻。 该组件提供了一种简单且精益/紧凑的方式来防止电喷雾离子源的毛细管中的液体过度传热。

公开(公告)号：EP1267387B1

公开(公告)日：2010-09-22

申请号：EP02013137.1

申请日：2002-06-14

Applicant: Bruker Daltonics, Inc.

Inventor： Park, Melvin A.

IPC: H01J49/06 ,  H01J49/10

CPC classification number: H01J49/063 ,  H01J49/107

公开(公告)号：EP2306491B1

公开(公告)日：2019-01-02

申请号：EP10009811.0

申请日：2005-10-11

Applicant: Bruker Daltonics, Inc.

Inventor： Steiner, Urs

IPC: H01J49/02 ,  G01T1/28 ,  B01D59/44 ,  H01J49/00

公开(公告)号：EP3032569B1

公开(公告)日：2018-10-17

申请号：EP15195298.3

申请日：2015-11-19

Applicant: Bruker Daltonics, Inc.

Inventor： Kaplan, Desmond Allen ,  Muntean, Felician ,  Zanon, Stephen

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/421

Abstract: The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.

公开(公告)号：EP3321952A1

公开(公告)日：2018-05-16

申请号：EP17196773.0

申请日：2017-10-17

Applicant: Bruker Daltonics, Inc.

Inventor： PARK, Melvin Andrew

IPC: H01J49/02 ,  H01J43/24

CPC classification number: H01J49/08 ,  H01J43/246 ,  H01J49/025 ,  H01J49/027 ,  H01J49/40

Abstract: The invention relates to the linear dynamic range of ion abundance measurement devices in mass spectrometers, such as time-of-flight mass spectrometers. The invention solves the problem of ion current peak saturation by producing a second ion measurement signal at an intermediate stage of amplification in a secondary electron multiplier, e.g. a signal generated between the two multichannel plates in chevron arrangement. Because saturation effects are observed only in later stages of amplification, the signal from the intermediate stage of amplification will remain linear even at high ion intensities and will remain outside saturation. In the case of a discrete dynode detector this could encompass, for example, placement of a detection grid between two dynodes near the middle of the amplification chain. The invention uses detection of the image current generated by the passing electrons.

Abstract translation: 本发明涉及质谱仪（例如飞行时间质谱仪）中的离子丰度测量装置的线性动态范围。 本发明通过在二次电子倍增器中的放大的中间阶段产生第二离子测量信号来解决离子电流峰值饱和的问题，例如， 人字形排列的两个多通道板之间产生的信号。 因为饱和效应仅在扩增的后期阶段才被观察到，所以即使在高离子强度下，来自扩增中间阶段的信号也将保持线性并且将保持在饱和之外。 在分立打拿极检测器的情况下，这可以包括例如在放大链中间附近的两个打拿极之间放置检测网格。 本发明使用检测由通过的电子产生的图像电流。