专利检索 ap:("C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening" OR "IRBM S.P.A.") AND inv:"ROSSETTI, Ilaria" 第 1 页

1.

发明公开
AZOLE DERIVATIVES AS SHP2 INHIBITORS 审中-公开

公开(公告)号：EP4345101A1

公开(公告)日：2024-04-03

申请号：EP22198899.1

申请日：2022-09-29

申请人： IRBM S.P.A. , C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： PETROCCHI, Alessia , MONTALBETTI, Christian , DI FABIO, Romano , CIAMMAICHELLA, Alina , ROSSETTI, Ilaria

IPC分类号： C07D471/20 , A61K31/438 , A61P35/00 , A61P35/02 , A61P35/04 , A61P9/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P11/00 , A61P27/00

摘要： The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.

2.

发明公开
SHP2 INHIBITORS 审中-公开

公开(公告)号：EP4010335A1

公开(公告)日：2022-06-15

申请号：EP20761156.7

申请日：2020-08-07

申请人： IRBM S.P.A. , C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： CIAMMAICHELLA, Alina , FERRIGNO, Federica , ONTORIA ONTORIA, Jesus Maria , PETROCCHI, Alessia , PONZI, Simona , ROSSETTI, Ilaria , SFERRAZZA, Alessio , TORRENTE, Esther

IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , A61P35/00 , A61K31/4545

3.

发明公开
(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER 审中-公开

公开(公告)号：EP4313983A1

公开(公告)日：2024-02-07

申请号：EP22714898.8

申请日：2022-04-01

申请人： C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening , IRBM S.P.A.

发明人： DI FABIO, Romano , MONTALBETTI, Christian , PETROCCHI, Alessia , GRILLO, Alessandro , RANDAZZO, Pietro , ROSSETTI, Ilaria , CIAMMAICHELLA, Alina

IPC分类号： C07D471/20 , C07D491/22 , A61K31/438 , A61K31/4985 , A61K31/497 , A61K31/444 , A61P35/00 , A61P35/02 , A61P35/04 , A61P9/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P11/00 , A61P27/00 , A61P27/02 , A61P29/00 , A61P3/00 , A61P3/10 , A61P7/00

4.

发明公开
AZABICYCLIC SHP2 INHIBITORS 审中-公开

公开(公告)号：EP4288431A1

公开(公告)日：2023-12-13

申请号：EP22705043.2

申请日：2022-02-08

申请人： IRBM S.P.A. , C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： CIAMMAICHELLA, Alina , DI FABIO, Romano , FERRIGNO, Federica , FEZZARDI, Paola , MONTALBETTI, Christian , PETROCCHI, Alessia , RELITTI, Nicola , ROSSETTI, Ilaria , SFERRAZZA, Alessio , TORRENTE, Esther , FERRANTE, Luca , GRILLO, Alessandro

IPC分类号： C07D409/14 , C07D401/14 , C07D417/14 , C07D401/04 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/497 , A61K31/4985 , A61P35/00 , A61P37/00

5.

发明公开
AZABICYCLIC SHP2 INHIBITORS 审中-公开

公开(公告)号：EP4039685A1

公开(公告)日：2022-08-10

申请号：EP21155769.9

申请日：2021-02-08

申请人： IRBM S.P.A. , C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： DI FABIO, Romano , PETROCCHI, Alessia , FERRANTE, Luca , GRILLO, Alessandro , SFERRAZZA, Alessio , MONTALBETTI, Christian , ROSSETTI, Ilaria , TORRENTE, Esther

IPC分类号： C07D409/14 , C07D401/14 , C07D417/14 , C07D487/04 , C07D519/00 , A61K31/497 , A61K31/4985 , A61P35/00 , A61P37/00

摘要： The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I):