公开(公告)号：EP4345101A1

公开(公告)日：2024-04-03

申请号：EP22198899.1

申请日：2022-09-29

申请人： IRBM S.P.A. ,  C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： PETROCCHI, Alessia ,  MONTALBETTI, Christian ,  DI FABIO, Romano ,  CIAMMAICHELLA, Alina ,  ROSSETTI, Ilaria

IPC分类号： C07D471/20 ,  A61K31/438 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P9/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P11/00 ,  A61P27/00

摘要： The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.

公开(公告)号：EP4282862A1

公开(公告)日：2023-11-29

申请号：EP22175308.0

申请日：2022-05-25

申请人： IRBM S.P.A. ,  C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： ALLI, Cristina ,  BRESCIANI, Alberto ,  DI FABIO, Romano ,  MONTALBETTI, Christian A.G.N. ,  ONTORIA ONTORIA, Jesus Maria ,  PAONESSA, Giacomo ,  QUOTADAMO, Antonio ,  TORRENTE DE HARO, Esther ,  BENCHEVA, Leda ,  AMAUDRUT, Jerome

IPC分类号： C07D271/04 ,  A61P31/14

摘要： The invention relates to compounds that are inhibitors of Flavivirus NS2B-NS3 proteases and inhibit replication of flavivirus in cells. Compounds of this invention are useful alone or in combination with other agents for use in the treatment of infections caused by Flaviviruses, in particular by Dengue, West Nile, Zika, Japan Encephalitis viruses.

公开(公告)号：EP4313983A1

公开(公告)日：2024-02-07

申请号：EP22714898.8

申请日：2022-04-01

申请人： C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening ,  IRBM S.P.A.

发明人： DI FABIO, Romano ,  MONTALBETTI, Christian ,  PETROCCHI, Alessia ,  GRILLO, Alessandro ,  RANDAZZO, Pietro ,  ROSSETTI, Ilaria ,  CIAMMAICHELLA, Alina

IPC分类号： C07D471/20 ,  C07D491/22 ,  A61K31/438 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/444 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P9/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P11/00 ,  A61P27/00 ,  A61P27/02 ,  A61P29/00 ,  A61P3/00 ,  A61P3/10 ,  A61P7/00

公开(公告)号：EP4288431A1

公开(公告)日：2023-12-13

申请号：EP22705043.2

申请日：2022-02-08

申请人： IRBM S.P.A. ,  C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： CIAMMAICHELLA, Alina ,  DI FABIO, Romano ,  FERRIGNO, Federica ,  FEZZARDI, Paola ,  MONTALBETTI, Christian ,  PETROCCHI, Alessia ,  RELITTI, Nicola ,  ROSSETTI, Ilaria ,  SFERRAZZA, Alessio ,  TORRENTE, Esther ,  FERRANTE, Luca ,  GRILLO, Alessandro

IPC分类号： C07D409/14 ,  C07D401/14 ,  C07D417/14 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/497 ,  A61K31/4985 ,  A61P35/00 ,  A61P37/00

公开(公告)号：EP4067358A1

公开(公告)日：2022-10-05

申请号：EP21166822.3

申请日：2021-04-02

申请人： C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening ,  IRBM S.P.A.

发明人： DI FABIO, Romano ,  MONTALBETTI, Christian ,  PETROCCHI, Alessia ,  GRILLO, Alessandro ,  RANDAZZO, Pietro

IPC分类号： C07D471/20 ,  C07D491/22 ,  A61K31/438 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/444 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P9/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P11/00 ,  A61P27/00 ,  A61P27/02 ,  A61P29/00 ,  A61P3/00 ,  A61P3/10 ,  A61P7/00

摘要： The present invention relates to compounds of formula (I)

The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'H,6'H-spiro[piperidine-4,5'-pyrrolo[1,2-b]pyrazol]-4'-amine derivatives and similar compounds.
The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof.
The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

公开(公告)号：EP4039685A1

公开(公告)日：2022-08-10

申请号：EP21155769.9

申请日：2021-02-08

申请人： IRBM S.P.A. ,  C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

发明人： DI FABIO, Romano ,  PETROCCHI, Alessia ,  FERRANTE, Luca ,  GRILLO, Alessandro ,  SFERRAZZA, Alessio ,  MONTALBETTI, Christian ,  ROSSETTI, Ilaria ,  TORRENTE, Esther

IPC分类号： C07D409/14 ,  C07D401/14 ,  C07D417/14 ,  C07D487/04 ,  C07D519/00 ,  A61K31/497 ,  A61K31/4985 ,  A61P35/00 ,  A61P37/00

摘要： The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I):

公开(公告)号：EP3833672A1

公开(公告)日：2021-06-16

申请号：EP19749375.2

申请日：2019-08-09

申请人： Ospedale San Raffaele S.r.l. ,  IRBM S.P.A. ,  Promidis S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： DE FRANCESCO, Raffaele ,  DONNICI, Lorena ,  GUIDOTTI, Luca ,  IANNACONE, Matteo ,  DI FABIO, Romano ,  SUMMA, Vincenzo ,  PRANDI, Adolfo ,  RANDAZZO, Pietro ,  GORNATI, Davide ,  GRILLO, Alessandro ,  FERRANTE, Luca ,  BENCHEVA, Leda Ivanova ,  DE MATTEO, Marilenia ,  FERRARA, Marco

IPC分类号： C07D513/14 ,  C07D515/04 ,  C07D515/14 ,  C07D515/18 ,  C07D519/00 ,  A61K31/554 ,  A61P31/20

公开(公告)号：EP3823957A1

公开(公告)日：2021-05-26

申请号：EP19744657.8

申请日：2019-07-19

申请人： Ospedale San Raffaele S.r.l. ,  IRBM S.P.A. ,  Promidis S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： DE FRANCESCO, Raffaele ,  PRANDI, Adolfo ,  RANDAZZO, Pietro ,  DONNICI, Lorena ,  GUIDOTTI, Luca ,  IANNACONE, Matteo ,  DI FABIO, Romano ,  SUMMA, Vincenzo ,  BENCHEVA, Leda Ivanova ,  DE MATTEO, Marilenia ,  FERRANTE, Luca

IPC分类号： C07D213/74 ,  A61K31/337 ,  A61K31/4025 ,  A61K31/44 ,  C07D213/76 ,  C07C311/44 ,  C07D207/14 ,  C07D211/58 ,  C07D211/96 ,  C07D305/08 ,  A61P31/20 ,  A61P31/18