公开(公告)号：EP1372844A4

公开(公告)日：2005-10-12

申请号：EP02736516

申请日：2002-03-25

Applicant: CALIFORNIA INST OF TECHN ,  CYMETECH LLC

Inventor： BELL ANDREW ,  GRUBBS ROBERT H ,  MORGAN JOHN P ,  MOORE JASON L

IPC: B01J31/22 ,  B01J23/46 ,  B01J27/24 ,  B01J31/00 ,  B01J31/18 ,  B01J31/24 ,  B01J37/34 ,  C07C6/04 ,  C07C6/06 ,  C07D233/00 ,  C07D233/02 ,  C07D233/54 ,  C07D233/56 ,  C07D233/58 ,  C07F15/00 ,  C08F4/44 ,  C08F4/80 ,  C08G61/08

CPC classification number: B01J31/2265 ,  B01J23/462 ,  B01J23/466 ,  B01J31/2273 ,  B01J31/24 ,  B01J31/2404 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07C6/04 ,  C07C6/06 ,  C07C2531/22 ,  C07F15/002 ,  C07F15/0046 ,  Y02P20/55

Abstract: The invention provides a method of making a ruthenium or osmium carbene catalyst having an imidazolidine in the presence of an olefin with the application of energy. The resulting metal compound has two carbene ligands, one from the original carbene, the other from the imidazolidine. The imidazolidine has bulky protecting groups in the two positions adjacent to the carbene carbon. The method of making the imidazoline from the salt in the presence of a base and chloroform is also disclosed.

Abstract translation: 本发明提供了一种在烯烃存在下使用能量制备具有咪唑烷的钌或锇卡宾催化剂的方法。 所得到的金属化合物具有两个卡宾配体，一个来自原卡宾，另一个来自咪唑烷。 咪唑烷在与卡宾碳相邻的两个位置上具有庞大的保护基团。 还公开了在碱和氯仿存在下由盐制备咪唑啉的方法。

公开(公告)号：EP1423195A4

公开(公告)日：2005-06-29

申请号：EP02791535

申请日：2002-06-14

Applicant: CALIFORNIA INST OF TECHN

Inventor： GRUBBS ROBERT H ,  SANFORD MELANIE S ,  MOORE JASON L ,  LOVE JENNIFER A ,  TRNKA TINA M

IPC: B01J23/46 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C6/04 ,  C07C6/06 ,  C07F15/00 ,  C08F4/80 ,  C08G61/06 ,  C08G61/08 ,  B01J31/00

CPC classification number: C07C6/04 ,  B01J23/462 ,  B01J23/466 ,  B01J31/181 ,  B01J31/1815 ,  B01J31/183 ,  B01J31/2273 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07C6/06 ,  C07C2531/22 ,  C07F15/002 ,  C07F15/0046 ,  C08G61/06

Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and XI are the same or different and are each independently an anionic ligand; L, L ?1' and L 2¿ are the same or different and are each independently a neutral electron donor ligand; and, R and R 1 are each independently hydrogen or a substituent selected from the group consisting of C¿1?-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl and silyl. Optionally, each of the R or R ?1¿ substituent group may be substituted with one or more moieties selected from the group consisting of C¿1?-C10 alkyl, C1-C10 alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from a halogen, a C1-C5 alkyl, C1-C5 alkoxy, and phenyl. Moreover, any of the catalyst ligands may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, halogen, alcohol, sulfonic acid, phosphine, imide, acetal, ketal, boronate, cyano, cyanohydrin, hydrazine, enamine, sulfone, sulfide, and sulfenyl. In certain embodiments, at least one of L, L ?l' and L 2¿ is an N-heterocyclic carbene ligand.