公开(公告)号：EP1373170A4

公开(公告)日：2007-03-21

申请号：EP02731215

申请日：2002-04-01

Applicant: CALIFORNIA INST OF TECHN

Inventor： GRUBBS ROBERT H ,  CHATTERJEE ARNAB K ,  CHOI TAE-LIM ,  GOLDBERG STEVEN D ,  LOVE JENNIFER A ,  MORGAN JOHN P ,  SANDERS DANIEL P ,  SCHOLL MATTHIAS ,  TOSTE F DEAN ,  TRNKA TINA M

IPC: C07C6/02 ,  C07C6/04 ,  C07C6/06 ,  C07C17/275 ,  C07C29/40 ,  C07C45/69 ,  C07C67/293 ,  C07C67/343 ,  C07C205/06 ,  C07C319/20 ,  C07C321/14 ,  C07D263/14 ,  C07D317/12 ,  C07D317/20 ,  C07D317/24 ,  C07F5/02 ,  C07F7/18 ,  C07F7/22 ,  C07F7/30 ,  C07F9/02 ,  C07F9/40 ,  C07F15/00

CPC classification number: C07F9/40 ,  C07C6/04 ,  C07C17/275 ,  C07C29/40 ,  C07C29/46 ,  C07C41/14 ,  C07C45/69 ,  C07C67/293 ,  C07C67/297 ,  C07C67/343 ,  C07C67/475 ,  C07C201/12 ,  C07C319/20 ,  C07C2531/22 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/74 ,  C07D263/14 ,  C07D317/12 ,  C07D317/20 ,  C07D317/24 ,  C07F7/1892 ,  C07F9/4015 ,  C07F15/0046 ,  C07C25/13 ,  C07C47/21 ,  C07C69/007 ,  C07C69/78 ,  C07C69/732 ,  C07C69/56 ,  C07C321/14 ,  C07C69/16 ,  C07C69/533 ,  C07C69/145 ,  C07C69/157 ,  C07C69/18 ,  C07C205/06 ,  C07C33/483

公开(公告)号：EP1423195A4

公开(公告)日：2005-06-29

申请号：EP02791535

申请日：2002-06-14

Applicant: CALIFORNIA INST OF TECHN

Inventor： GRUBBS ROBERT H ,  SANFORD MELANIE S ,  MOORE JASON L ,  LOVE JENNIFER A ,  TRNKA TINA M

IPC: B01J23/46 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C6/04 ,  C07C6/06 ,  C07F15/00 ,  C08F4/80 ,  C08G61/06 ,  C08G61/08 ,  B01J31/00

CPC classification number: C07C6/04 ,  B01J23/462 ,  B01J23/466 ,  B01J31/181 ,  B01J31/1815 ,  B01J31/183 ,  B01J31/2273 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07C6/06 ,  C07C2531/22 ,  C07F15/002 ,  C07F15/0046 ,  C08G61/06

Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and XI are the same or different and are each independently an anionic ligand; L, L ?1' and L 2¿ are the same or different and are each independently a neutral electron donor ligand; and, R and R 1 are each independently hydrogen or a substituent selected from the group consisting of C¿1?-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl and silyl. Optionally, each of the R or R ?1¿ substituent group may be substituted with one or more moieties selected from the group consisting of C¿1?-C10 alkyl, C1-C10 alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from a halogen, a C1-C5 alkyl, C1-C5 alkoxy, and phenyl. Moreover, any of the catalyst ligands may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, halogen, alcohol, sulfonic acid, phosphine, imide, acetal, ketal, boronate, cyano, cyanohydrin, hydrazine, enamine, sulfone, sulfide, and sulfenyl. In certain embodiments, at least one of L, L ?l' and L 2¿ is an N-heterocyclic carbene ligand.

公开(公告)号：EP1497299A4

公开(公告)日：2006-08-02

申请号：EP03718252

申请日：2003-04-07

Applicant: CALIFORNIA INST OF TECHN

Inventor： GRUBBS ROBERT H ,  MORGAN JOHN P ,  LOVE JENNIFER A ,  TRNKA TINA M

IPC: C07C253/30 ,  C07C255/15 ,  C07C255/34 ,  C08F2/00 ,  C07F9/00 ,  C07F9/28 ,  C07F15/00

CPC classification number: C07C253/30 ,  C07C255/15 ,  C07C255/34

Abstract: The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.

Abstract translation: 本发明涉及使用第8族过渡金属亚烷基络合物作为烯烃交叉复分解反应的催化剂。 具体而言，用N-杂环卡宾配体和至少一个杂环基形式的电子给体配体取代的钌和锇的亚烷基配合物用于催化交叉复分解反应，以提供直接被电子取代的烯烃产物 - 提款组。