公开(公告)号：EP1572576A2

公开(公告)日：2005-09-14

申请号：EP03739310.5

申请日：2003-06-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： TAI, Yu-Chong ,  XIE, Jun ,  HE, Qing ,  LEE, Terry, Dwight

IPC: B81C1/00

CPC classification number: G01N30/6095 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/046 ,  F04B17/00 ,  F04B19/006 ,  G01N30/32 ,  G01N30/7266 ,  G01N2030/285 ,  G01N2030/326 ,  H01J49/04

Abstract: Electrochemical actuation is adopted in an integrated microfluidic chip to transfer fluid for sample preparation, separation and detection. The electrochemical actuation is capable of producing high pressure for on-chip fluidic handling. Technologies and methods are also developed to use only electrical source to control on-chip fluid handling without any external fluidic support. Applications for the devices and methods include micro scale HPLC, ESI-MS, etc.

公开(公告)号：EP1485328A1

公开(公告)日：2004-12-15

申请号：EP03716653.5

申请日：2003-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： TAI, Yu-Chong ,  HE, Qing

IPC: C03C1/00

CPC classification number: B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

Abstract: A method for integrally fabricated MEMs devices with include micro or nanoparticles by providing a mixture (16) of sacrificial material (12) and a multiplicity of particles (10), disposing the mixture (16) on a substrate (14), fabricating a MEMs structure on the substrate (14) including at least part of the mixture (16), so that at least some of the mixture (16) is enclosed in the MEMs structure, removing the sacrificial material (12), and leaving at least some of the multiplicity of particles (10) substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles (10), which may be microbeads or nanobeads, are included.

公开(公告)号：EP1673152A2

公开(公告)日：2006-06-28

申请号：EP04786516.7

申请日：2004-08-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  City of Hope

Inventor： TAI, Yu-Chong ,  HE, Qing ,  XIE, Jun ,  PANG, Changlin ,  LEE, Terry, D.

IPC: B01D1/00

CPC classification number: H05K3/284 ,  G01N30/6047 ,  G01N30/6095 ,  G01N2030/645 ,  G03F1/80 ,  G01N2030/625

Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, frits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.