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1.发明公开
公开(公告)号：EP1908354A4
公开(公告)日：2011-12-28
申请号：EP06781534
申请日：2006-07-25
申请人： CALPIS CO LTD
发明人： YASUDA MARIKO , SHINODA TADASHI , YAMAMOTO NAOYUKI
IPC分类号： A23C9/127 , A23C9/12 , A23L1/29 , A23L1/305 , A23L2/38 , A61K38/00 , A61K38/06 , A61P9/12 , C12N9/48 , C12P21/02 , C12P21/06
CPC分类号： C12Y304/00 , A23C9/1209 , A23C9/1275 , A23L2/38 , A23L33/18 , A23V2002/00 , A23Y2220/39 , C12P21/06 , A23V2200/326
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公开(公告)号：EP1552843A4
公开(公告)日：2009-08-19
申请号：EP03733214
申请日：2003-05-30
申请人： CALPIS CO LTD
CPC分类号： C12R1/225 , A23K10/18 , A23L33/135 , A61K35/742 , A61K35/744 , C12R1/125
摘要： An accelerating agent for elimination of dioxins which comprises, as an active ingredient, a microorganism having an activity of accelerating elimination of dioxins in the body to the outside of the body.
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3.发明公开BIOLOGICALLY NON-DEGRADABLE PEPTIDE, ANGIOTENSIN CONVERTING ENZYME INHIBITOR, DRUG AND FUNCTIONAL FOOD 有权生物降解的肽酶抑制剂血管紧张素转换酶，药物和功能性食品
公开(公告)号：EP1661909A4
公开(公告)日：2006-08-30
申请号：EP04771089
申请日：2004-07-30
申请人： CALPIS CO LTD
发明人： YAMAMOTO NAOYUKI , MIZUNO SEIICHI , NISHIMURA SHINGO , GOTOU TAKANOBU , MATSUURA KEIICHI , SHINODA TADASHI
IPC分类号： C07K5/062 , A23L1/305 , A61K38/00 , A61K38/01 , A61K38/55 , A61P9/12 , A61P43/00 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , C07K5/083 , C12P21/06
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： It is intended to provide a novel biologically non-degradable peptide which is easily absorbed but hardly degraded in vivo when administered via, for example, the oral route and expected as effectively exerting functions such as a hypotensive effect in vivo; an ACE inhibitor using the peptide; and a drug or a functional food expected as effectively exerting a hypotensive effect in vivo. The biologically non-degradable peptide as described above is a dipeptide or a tripeptide having Pro at its carboxy end selected from the group consisting of Ile Pro, Glu Pro, Arg Pro, Gln Pro, Met Pro and Ser Pro Pro.
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公开(公告)号：EP1669463A4
公开(公告)日：2006-08-23
申请号：EP04771088
申请日：2004-07-30
申请人： CALPIS CO LTD
发明人： YAMAMOTO NAOYUKI , MIZUNO SEIICHI , NISHIMURA SHINGO , GOTOU TAKANOBU , MATSUURA KEIICHI , SHINODA TADASHI
IPC分类号： A61K38/01 , A23L1/305 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/068 , C07K5/072 , C07K5/08 , C07K5/083 , C12P21/06
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： A casein hydrolyzate, especially one whose in vivo manifestation of functions, such as antihypertensive activity, is promising, which casein hydrolyzate comprises a peptide, such as a nonbiodegradable peptide having minimized its in vivo zymolytic activity, and free amino acids; a process for producing the same; and use thereof. In particular, the casein hydrolyzate is obtained by hydrolyzing animal milk casein into an average chain length of 2.1 or less in terms of amino acid residue quantity, and contains free amino acids and a peptide, such as a nonbiodegradable peptide, e.g., XaaPro or XaaProPro. The casein hydrolyzate exhibits an ACE inhibitory activity or antihypertensive activity.
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公开(公告)号：EP1354592A4
公开(公告)日：2005-06-08
申请号：EP01994994
申请日：2001-12-25
申请人： CALPIS CO LTD
发明人： YAMAMOTO NAOYUKI , MASUDA OSAMU , KANEKO KYOUKO , IKEDA NAGISA , ISHIDA YUU , KUSUDA DAISUKE , SHINODA TADASHI
CPC分类号： A61K35/20 , A61K35/747 , Y10S514/892 , A61K2300/00
摘要： Medicines for relieving intestinal disorders which contain viable cells of a strain belonging to Lactobacillus helveticus. This strain is preferably characterized by a resistance to a specific bile acid, adhesiveness to intestinal epithelial cells, etc. A method of controlling intestinal functions which involves the step of administering such a medicine to a subject with a need for the control of intestinal functions. When administered to humans or the like, these medicines exert effects of elevating stool frequency, etc., thereby efficaciously improving the intestinal environment.
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