-
公开(公告)号：EP1175445A1
公开(公告)日：2002-01-30
申请号：EP00927483.8
申请日：2000-05-02
发明人： THOMPSON, Julia, Elizabeth , LENNARD, Simon, Nicholas , WILTON, Alison, Jane , BRADDOCK, Peta, Sally, Helena , DU FOU, Sarah, Leila , MCCAFFERTY, John, Gerald , CONROY, Louise, Anne , TEMPEST, Philip, Ronald
IPC分类号： C07K16/22 , A61K39/395 , G01N33/577 , A61P35/00 , A61P13/12 , A61P27/02 , A61P37/00 , A61P11/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGFβ1 and are useful in treating conditions associated with excess TGFβ1 activity, such as fibrosis, immune responses and tumour progression.
-
2.发明授权SPECIFIC BINDING MEMBERS FOR HUMAN TRANSFORMING GROWTH FACTOR BETA; MATERIALS AND METHODS 失效特异性结合合作伙伴人转化生长因子和方法
公开(公告)号：EP0853661B1
公开(公告)日：2000-03-15
申请号：EP96932730.3
申请日：1996-10-07
发明人： THOMSON, Julia, Elizabeth , VAUGHAN, Tristan, John , WILLIAMS, Andrew, James , GREEN, Jonathan, Alexander , JACKSON, Ronald, Henry , BACON, Louise , JOHNSON, Kevin, Stuart , WILTON, Alison, Jane , TEMPEST, Philip, Ronald , POPE, Anthony, Richard
IPC分类号： C12N5/10 , C12N15/13 , C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K38/00 , C07K2317/21 , C07K2317/622
-
3.发明公开SPECIFIC BINDING MEMBERS FOR HUMAN TRANSFORMING GROWTH FACTOR BETA; MATERIALS AND METHODS 失效特异性结合合作伙伴人转化生长因子和方法
公开(公告)号：EP0853661A1
公开(公告)日：1998-07-22
申请号：EP96932730.0
申请日：1996-10-07
发明人： THOMSON, Julia, Elizabeth , VAUGHAN, Tristan, John , WILLIAMS, Andrew, James , GREEN, Jonathan, Alexander , JACKSON, Ronald, Henry , BACON, Louise , JOHNSON, Kevin, Stuart , WILTON, Alison, Jane , TEMPEST, Philip, Ronald , POPE, Anthony, Richard
IPC分类号： C12N15 , A61K31 , A61K39 , A61P1 , A61P11 , A61P13 , A61P17 , A61P25 , A61P27 , A61P29 , A61P37 , C07K16 , C12N5 , C12P21 , A61K38
CPC分类号： C07K16/22 , A61K38/00 , C07K2317/21 , C07K2317/622
摘要： Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both, preferentially compared with TGFβ3. Specific binding members may be isolated and utilised in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for a particularly advantageous specific binding member which binds the active form of TGFβ2, neutralising its activity, but does not bind the latent form.
-
公开(公告)号：EP1175445B1
公开(公告)日：2004-07-28
申请号：EP00927483.8
申请日：2000-05-02
发明人： THOMPSON, Julia, Elizabeth , LENNARD, Simon, Nicholas , WILTON, Alison, Jane , BRADDOCK, Peta, Sally, Helena , DU FOU, Sarah, Leila , MCCAFFERTY, John, Gerald , CONROY, Louise, Anne , TEMPEST, Philip, Ronald
IPC分类号： C07K16/22 , A61K39/395 , G01N33/577 , A61P35/00 , A61P13/12 , A61P27/02 , A61P37/00 , A61P11/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622
-
5.发明公开SPECIFIC BINDING PROTEINS INCLUDING ANTIBODIES WHICH BIND TO THE NECROTIC CENTRE OF TUMOURS, AND USES THEREOF 有权特异性抗体含结合蛋白的中心坏死肿瘤约束力及其用途
公开(公告)号：EP1092028A1
公开(公告)日：2001-04-18
申请号：EP99929554.6
申请日：1999-07-02
IPC分类号： C12N15/13 , C12N15/62 , C07K16/18 , C07K16/46 , G01N33/577 , A61K51/10 , A61K39/395
CPC分类号： A61K51/1018 , C07K16/18 , C07K2317/24 , C07K2319/00 , Y10S424/809
摘要： Specific binding members, based on the third CDR of the antibody NHS76 (SEQ ID NO: 2) are provided, together with their use in methods of treatment and diagnosis.
-
-
-
-
搜索结果
5 条记录 (耗时 0.015 秒)
