公开(公告)号：EP2902076A1

公开(公告)日：2015-08-05

申请号：EP15155658.6

申请日：2007-06-29

申请人： CARDIAC PACEMAKERS, INC.

发明人： Libbus, Imad ,  Spinelli, Julio C.

IPC分类号： A61N1/36

CPC分类号： A61N1/36132 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4047 ,  A61N1/3601 ,  A61N1/36114

摘要： Various system embodiments comprise a neural stimulation delivery system adapted to deliver a neural stimulation signal for use in delivering a neural stimulation therapy, a side effect detector, and a controller. The controller is adapted to control the neural stimulation delivery system, receive a signal indicative of detected side effect, determine whether the detected side effect is attributable to delivered neural stimulation therapy, and automatically titrate the neural stimulation therapy to abate the side effect. In various embodiments, the side effect detector includes a cough detector. In various embodiments, the controller is adapted to independently adjusting at least one stimulation parameter for at least one phase in the biphasic waveform as part of a process to titrate the neural stimulation therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括适于递送用于递送神经刺激疗法的神经刺激信号的神经刺激递送系统，副作用检测器和控制器。 控制器适于控制神经刺激递送系统，接收指示检测到的副作用的信号，确定检测到的副作用是否归因于递送的神经刺激疗法，并且自动滴定神经刺激疗法以减轻副作用。 在各种实施例中，副作用检测器包括咳嗽检测器。 在各种实施例中，控制器适于独立地调整两相波形中的至少一个相位的至少一个刺激参数，作为滴定神经刺激疗法的过程的一部分。 本文提供了其它方面和实施例。

公开(公告)号：EP2457616A1

公开(公告)日：2012-05-30

申请号：EP12153741.9

申请日：2007-06-15

申请人： Cardiac Pacemakers, Inc.

发明人： Libbus, Imad ,  Caparso, Anthony V. ,  Kramer, Andrew P.

IPC分类号： A61N1/36 ,  A61N1/00 ,  A61N1/372

CPC分类号： A61N1/05 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/37211 ,  A61N1/37252 ,  A61N1/37288

摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers neurostimulation percutaneously to a stimulation target in the patient's body using at least one percutaneous stimulation electrode having a distal end lodged on or near the stimulation target.

摘要翻译： 神经刺激装置包括使用支撑元件佩戴的外部神经刺激器，其支撑患者身体的一部分。 外部神经刺激器提供神经刺激以调节患者的心血管功能。 在一个实施例中，外部刺激器使用至少一个经皮刺激电极将刺激神经刺激经皮刺激到患者体内的刺激目标，所述经皮刺激电极具有放置在刺激靶上或附近的远端。

公开(公告)号：EP2316525B1

公开(公告)日：2016-01-06

申请号：EP10193036.0

申请日：2007-08-20

申请人： CARDIAC PACEMAKERS, INC.

发明人： Brockway, Marina V. ,  Libbus, Imad ,  Siejko, Krzysztof Z. ,  Sweeney, Robert J.

IPC分类号： A61N1/36

CPC分类号： A61N1/3727 ,  A61B5/02405 ,  A61B5/4035 ,  A61B5/4839 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/362 ,  A61N1/37264

公开(公告)号：EP2213331A3

公开(公告)日：2014-08-06

申请号：EP10150476.9

申请日：2005-11-14

申请人： Cardiac Pacemakers, Inc.

发明人： Libbus, Imad ,  Kramer, Andrew P. ,  Moffitt, Julia

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36557 ,  A61N1/36564

摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

公开(公告)号：EP2213331A2

公开(公告)日：2010-08-04

申请号：EP10150476.9

申请日：2005-11-14

申请人： Cardiac Pacemakers, Inc.

发明人： Libbus, Imad ,  Kramer, Andrew P. ,  Moffitt, Julia

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36557 ,  A61N1/36564

摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

摘要翻译： 本主题的各个方面涉及一种装置。 在各种实施例中，该设备包括适于连接至少一个引线，连接到端口的CRM功能模块和适于使用引线提供至少一个CRM功能的至少一个端口，神经功能模块和连接到 CRM功能模块和神经功能模块。 所述至少一个CRM功能包括向引线提供电信号以捕获心脏组织的功能。 所述神经功能模块包括连接到所述端口的信号处理模块，并适于接收并处理来自所述导线的神经交通信号并将其处理成指示神经流量的信号。 控制器适于基于指示神经流量的信号来实施CRM治疗。 本文提供了其他方面。

公开(公告)号：EP2213330A2

公开(公告)日：2010-08-04

申请号：EP10157396.2

申请日：2005-11-17

申请人： Cardiac Pacemakers, Inc.

发明人： Libbus, Imad ,  Kramer, Andrew P. ,  Moffitt, Julia

IPC分类号： A61N1/36

CPC分类号： A61N1/36114

摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.

摘要翻译： 各种装置实施例包括脉冲发生器，信号处理模块和控制器。 脉冲发生器适于提供要在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。 信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经传播。 控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。 控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。 本文提供了其它方面和实施例。

公开(公告)号：EP2179764B1

公开(公告)日：2016-03-30

申请号：EP09171760.3

申请日：2006-05-08

申请人： CARDIAC PACEMAKERS, INC.

发明人： Libbus, Imad ,  Kramer, Andrew P. ,  Linder, William J. ,  Stahmann, Jeffrey E.

IPC分类号： A61N1/362 ,  A61N1/37 ,  A61N1/36 ,  A61N1/365

CPC分类号： A61N1/37 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/362 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/36592 ,  A61N1/3987

公开(公告)号：EP2213330A3

公开(公告)日：2014-08-13

申请号：EP10157396.2

申请日：2005-11-17

申请人： Cardiac Pacemakers, Inc.

发明人： Libbus, Imad ,  Kramer, Andrew P. ,  Moffitt, Julia

IPC分类号： A61N1/36

CPC分类号： A61N1/36114

摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.

公开(公告)号：EP2301623A3

公开(公告)日：2011-06-22

申请号：EP10181222.0

申请日：2006-03-28

申请人： Cardiac Pacemakers, Inc.

发明人： Moffitt, Julia ,  Libbus, Imad

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/37288 ,  A61M31/00 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36053 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/37217

摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrodes chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.

摘要翻译： 本文件讨论了经血管刺激神经或神经干的装置，系统和方法等。 在一个示例中，设备被配置为经血管经血管刺激神经干。 该装置包括可伸缩电极，其可长期植入靠近神经干的血管中。 可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面区域。 电引线连接到可膨胀电极。 植入式脉冲发生器耦合到引线并被配置为通过引线向电极传递电刺激信号。 在一个示例性方法中，电信号从植入的医疗装置递送到临近神经干的血管中长期植入的电极，以将神经刺激从电极经血管递送到神经干。

公开(公告)号：EP2316525A1

公开(公告)日：2011-05-04

申请号：EP10193036.0

申请日：2007-08-20

申请人： CARDIAC PACEMAKERS, INC.

发明人： Brockway, Marina V. ,  Libbus, Imad ,  Siejko, Krzysztof Z. ,  Sweeney, Robert J.

IPC分类号： A61N1/36

CPC分类号： A61N1/3727 ,  A61B5/02405 ,  A61B5/4035 ,  A61B5/4839 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/362 ,  A61N1/37264

摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.

摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，所以用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。