Stabilisation of a mutant micro-organism population
    2.
    发明公开
    Stabilisation of a mutant micro-organism population 失效
    突变微生物群体的稳定

    公开(公告)号:EP0098750A3

    公开(公告)日:1986-04-16

    申请号:EP83303840

    申请日:1983-07-01

    IPC分类号: C12P01/00 C12N15/00 C12P07/44

    摘要: This invention provides a process for stabilising a population of a mutant micro-organism in a bioconversion system whereby growth of revertant cells is suppressed. The process involves limiting a nutrient which is essential for cell growth so that the cells selectively grow on a growth carbon source rather than on a non-growth carbon source which is present. The revertant cells being suppressed have a similar ability as the parent strain of the mutant micro-organism to grow on the non-growth carbon source in the bioconversion system. The non-growth carbon source in the bioconversion system is metabolised to an extracellular accumulating quantity of a desired metabolite, e.g., toluene is converted to muconic acid.