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1.发明公开METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR TREATMENT AND MANAGEMENT OF MACULAR DEGENERATION 审中-公开使用方法选择性细胞因子和组合物MIT-抑制剂来治疗黄斑变性UNDVERSORGUNG作者
公开(公告)号：EP1567148A4
公开(公告)日：2010-09-15
申请号：EP03779423
申请日：2003-10-31
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K31/454 , A61K31/522 , A61K31/545 , A61K31/557 , A61K31/56 , A61K38/18 , A61K38/21 , A61K38/27 , A61K31/40 , A61K31/00 , A61K31/4035 , A61P27/02
CPC分类号： A61K38/185 , A61K31/454 , A61K31/522 , A61K31/545 , A61K31/557 , A61K31/56 , A61K38/21 , A61K38/27 , A61K2300/00
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2.发明公开SELECTIVE CYTOKINE INHIBITORY DRUGS FOR TREATING MYELODYSPLASTIC SYNDROME 审中-公开选择性细胞因子消炎药用于治疗骨髓增生异常综合征
公开(公告)号：EP1551385A4
公开(公告)日：2008-10-22
申请号：EP03726263
申请日：2003-04-13
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K20060101 , A61K31/21 , A61K31/27 , A61K31/34 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/44 , A61K31/47
CPC分类号： A61K31/203 , A61K31/21 , A61K31/34 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/522 , A61K35/28 , A61K35/50 , A61K35/51 , A61K38/1793 , A61K38/1816 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2053 , A61K45/06 , A61K2300/00
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3.发明公开METHODS OF USING JNK OR MKK INHIBITORS TO MODULATE CELL DIFFERENTIATION AND TO TREAT MYELOPROLIFERATIVE DISORDERS AND MYELODYSPLASTIC SYNDROMES 审中-公开方法或JNK MKK抑制剂在细胞分化的调节而烦恼治疗和骨髓增生性骨髓增生异常综合征使用
公开(公告)号：EP1525308A4
公开(公告)日：2006-11-02
申请号：EP03756349
申请日：2003-05-30
申请人： CELGENE CORP
IPC分类号： A61K31/00 , A61K31/403 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/48 , A61K31/505 , A61K35/12 , A61K35/14 , A61K35/26 , A61K35/44 , A61K45/00 , A61K48/00 , A61P7/06 , A61P35/02 , A61P43/00 , C12N5/074 , C12N5/0789 , C12N15/00 , A61K31/40 , A61K31/44 , A61K31/525 , A61K31/535 , A61K31/655 , C12N5/16 , C12N9/12
CPC分类号： C12N5/0647 , A61K31/00 , A61K31/403 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/505 , A61K2035/124 , C12N5/0607 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/70
摘要： The present invention provides methods of modulating mammalian, particularly human, stem cell and progenitor cell differentiation to regulate and control the differentiation and maturation of these cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem cell populations along specific cell and tissue lineages, particularly embryonic-like stem cells originating from a postpartum placenta or stem cells isolated form sources such as cord blood. The invention also relates to the treatment or prevention of myelodysplastic syndrome or myeloproliferative syndrome, or symptoms thereof, comprising administration of JNK or MKK inhibitors, alone or in combination, as well as with or without the use of unconditioned cells or cells conditioned in accordance with other aspects of the invention. Finally, the invention relates to the use of such differentiated stem cells in transplantation and other medical treatments.
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4.发明公开METHODS AND COMPOSITIONS USING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES 审中-公开方法和组合物选择性细胞因子抗炎药是治疗癌症和其他疾病的治疗和护理
公开(公告)号：EP1556033A4
公开(公告)日：2006-05-31
申请号：EP03728967
申请日：2003-05-16
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K45/00 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/515 , A61K31/573 , A61K31/704 , A61K31/724 , A61K38/18 , A61K38/20 , A61K45/06 , A61P1/04 , A61P1/16 , A61P3/06 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P11/16 , A61P17/02 , A61P17/06 , A61P17/10 , A61P19/02 , A61P19/08 , A61P25/00 , A61P27/02 , A61P27/06 , A61P27/10 , A61P27/14 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07D209/46 , C07J5/00 , A61P31/22
CPC分类号： A61K45/06 , A61K31/4035 , A61K31/425 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/515 , A61K31/704 , A61K31/724
摘要： Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of a selective cytokine inhibitory drug. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
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5.发明公开METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS 审中-公开方法石棉相关疾病和病症的治疗与护理使用和组合物PDE4调节剂
公开(公告)号：EP1684741A4
公开(公告)日：2010-01-27
申请号：EP04800841
申请日：2004-11-04
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K31/4035 , A61K20060101 , A61K31/28 , A61K31/335 , A61K31/40 , A61K31/44 , A61K31/519 , A61K31/70 , A61K31/704 , A61K31/7048 , A61K38/19 , A61K38/20
CPC分类号： A61K31/4035 , A61K2300/00
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6.发明公开METHODS AND COMPOSITIONS USING IMMUNOMODULATORY COMPOUNDS FOR TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES 审中-公开用于治疗方法和组合物具有免疫调节化合物或 护理癌症和其他疾病
公开(公告)号：EP1635826A4
公开(公告)日：2010-01-20
申请号：EP04751400
申请日：2004-05-05
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K31/454 , A61K31/00 , A61K31/44 , A61K41/00 , A61K45/06 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/00 , A61K31/203 , A61K31/404 , A61K31/415 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/522 , A61K31/573 , A61K31/704 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K41/00 , A61K45/06 , A61K2300/00
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7.发明公开METHODS OF USING AND COMPOSITIONS COMPRISING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT AND MANAGEMENT OF MYELODYSPLASTIC SYNDROMES 审中-公开使用方法和组合物治疗和供应骨髓增生异常综合征的免疫调节化合物的
公开(公告)号：EP1744749A4
公开(公告)日：2009-04-22
申请号：EP04821987
申请日：2004-04-14
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K31/445 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/20 , A61K45/06 , C07D401/04 , C07K14/435 , C07K14/52 , C07K14/53 , C07K14/54 , C07K14/55
CPC分类号： C08G73/00 , A61K31/203 , A61K31/437 , A61K31/445 , A61K31/454 , A61K31/475 , A61K31/497 , A61K31/506 , A61K31/573 , A61K31/7068 , A61K35/28 , A61K35/50 , A61K35/51 , A61K38/1793 , A61K38/1816 , A61K38/193 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing and/or managing myelodysplastic syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient, and/or the transplantation of blood or cells. Specific second active ingredients are capable of affecting or blood cell production. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
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8.发明公开METHODS OF USING AND COMPOSITIONS COMPRISING THALIDOMIDE FOR TREATMENT, MODIFICATION AND MANAGEMENT OF FIBROMYALGIA 审中-公开使用方法和组合物沙利度胺治疗，修改和纤维肌痛供应
公开(公告)号：EP1680132A4
公开(公告)日：2009-01-14
申请号：EP04796214
申请日：2004-10-22
申请人： CELGENE CORP
发明人： ZELDIS JEROME B , FALECK HERBERT
IPC分类号： A61K31/70 , A61K20060101 , A61K31/19 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/485 , A61K31/497 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/56 , A61K31/60 , A61K31/7048 , A61P19/04
CPC分类号： A61K31/70 , A61K31/19 , A61K31/415 , A61K31/445 , A61K31/454 , A61K31/497 , A61K31/551 , A61K31/553 , A61K31/56 , A61K31/60 , A61K2300/00
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9.发明公开METHODS OF USING AND COMPOSITIONS COMPRISING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT AND MANAGEMENT OF SKIN DISEASES OR DISORDERS 审中-公开使用方法免疫调节化合物和含组合物皮肤疾病和病症的治疗和护理
公开(公告)号：EP1737453A4
公开(公告)日：2008-11-26
申请号：EP05732239
申请日：2005-03-18
申请人： CELGENE CORP
发明人： ZELDIS JEROME B , HARIRI ROBERT J
IPC分类号： A61K31/445 , A61K31/19 , A61K31/59 , A61K36/28 , A61K36/575 , A61K38/21 , A61K39/08 , C07D401/00 , C07D401/04
CPC分类号： A61K31/19 , A61K31/59 , A61K36/28 , A61K36/575 , A61K2300/00
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10.发明公开METHODS AND COMPOSITIONS USING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES 审中-公开方法和组合物选择性细胞因子消炎药，用于治疗与供给癌症和其他疾病的
公开(公告)号：EP1567154A4
公开(公告)日：2006-05-31
申请号：EP03783234
申请日：2003-11-06
申请人： CELGENE CORP
发明人： ZELDIS JEROME B
IPC分类号： A61K31/00 , A61K31/40 , A61K31/4035 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/515 , A61K45/06 , A61P1/04 , A61P19/02 , A61P27/02 , A61P27/06 , A61P31/22 , A61P35/00
CPC分类号： A61K31/40 , A61K31/00 , A61K31/4035 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/454 , A61K31/522 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K45/06 , A61K2300/00
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