公开(公告)号：EP3362075A1

公开(公告)日：2018-08-22

申请号：EP16856249.4

申请日：2016-10-14

申请人： CELULARITY, INC.

发明人： ZHANG, Xiaokui ,  DJURETIC, Ivana ,  KANG, Lin ,  VOSKINARIAN-BERSE, Vanessa ,  STOUT, Bhavani ,  HARIRI, Robert J. ,  HOFGARTNER, Wolfgang ,  EDINGER, James ,  LAW, Eric ,  JANKOVIC, Vladimir

IPC分类号： A61K35/17 ,  A61P35/00 ,  C12N5/0783

CPC分类号： C12N5/0646 ,  A61K35/17 ,  C12N5/0634 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/30 ,  C12N2501/999 ,  C12N2506/03

摘要： Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.

公开(公告)号：EP3310173A1

公开(公告)日：2018-04-25

申请号：EP16800648.4

申请日：2016-05-25

申请人： CELULARITY, INC.

发明人： KARASIEWICZ-MENDEZ, Kathy, E. ,  FRANCKI, Aleksandar ,  TURNER, Jeffrey ,  LAW, Eric ,  PAREDES, Jennifer ,  LABAZZO, Kristen ,  RANA, Hemlata ,  HOFGARTNER, Wolfgang ,  HARIRI, Robert, J.

IPC分类号： A01N63/00 ,  C12N5/00

CPC分类号： C12N5/0605 ,  A61K9/0019 ,  A61K9/0085 ,  A61K35/28 ,  A61K35/50 ,  A61K47/36 ,  A61K47/42 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61P9/10 ,  C12N5/069 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2308 ,  C12N2501/2318 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/025

摘要： Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.

公开(公告)号：EP3838280A1

公开(公告)日：2021-06-23

申请号：EP20204692.6

申请日：2013-12-06

申请人： Celularity Inc.

发明人： HARIRI, Robert, J. ,  GURNEY, Jodi, P. ,  BHATIA, Mohit, B. ,  HOFGARTNER, Wolfgang

IPC分类号： A61K35/50 ,  A61K35/12 ,  A61P17/02 ,  C07K14/78

摘要： Provided herein are uses of compositions comprising extracellular matrix (ECM) and compositions comprising ECM components in the treatment of non-dental oral lesions.

公开(公告)号：EP2793912B1

公开(公告)日：2020-03-18

申请号：EP12860504.5

申请日：2012-12-21

申请人： Celularity, Inc.

发明人： BHATIA, Mohit, B. ,  HARIRI, Robert, J. ,  HOFGARTNER, Wolfgang ,  WANG, Jia-lun ,  YI, Qian

IPC分类号： A61K9/14 ,  A61F13/00 ,  A61L33/00 ,  A61L27/48 ,  A61K35/50 ,  A61L27/36 ,  A61P3/00 ,  A61P5/00 ,  A61P15/08