公开(公告)号：EP3362075A1

公开(公告)日：2018-08-22

申请号：EP16856249.4

申请日：2016-10-14

申请人： CELULARITY, INC.

发明人： ZHANG, Xiaokui ,  DJURETIC, Ivana ,  KANG, Lin ,  VOSKINARIAN-BERSE, Vanessa ,  STOUT, Bhavani ,  HARIRI, Robert J. ,  HOFGARTNER, Wolfgang ,  EDINGER, James ,  LAW, Eric ,  JANKOVIC, Vladimir

IPC分类号： A61K35/17 ,  A61P35/00 ,  C12N5/0783

CPC分类号： C12N5/0646 ,  A61K35/17 ,  C12N5/0634 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/30 ,  C12N2501/999 ,  C12N2506/03

摘要： Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.

公开(公告)号：EP3986381A1

公开(公告)日：2022-04-27

申请号：EP20742527.3

申请日：2020-06-19

申请人： Celularity Inc.

发明人： HARIRI, Robert J. ,  ZHANG, Xiaokui ,  YE, Qian ,  HE, Shuyang ,  HARIRI, Haley M. ,  SHAH, Navjot ,  SOMANCHI, Srinivas ,  STOUT, Bhavani

IPC分类号： A61K9/127 ,  A61K9/50 ,  A61K35/00 ,  A61K35/50 ,  A61K45/06 ,  A61K51/12 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P27/02 ,  C12N15/113 ,  C12N15/88