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    Controlled flow instrument for microwave assisted chemical process
    2.
    发明公开
    Controlled flow instrument for microwave assisted chemical process 有权
    用于微波辅助化学过程的受控流量仪器

    公开(公告)号：EP1547681A2

    公开(公告)日：2005-06-29

    申请号：EP04255177.0

    申请日：2004-08-27

    申请人： CEM Corporation

    发明人： Collins Jr, Michael John ,  King, Edward Earl ,  Thomas, James Edward ,  Hargett Jr., Wyatt Price ,  Lambert, Joseph Joshua

    IPC分类号： B01J19/12

    CPC分类号： B01J19/126 ,  B01J4/02 ,  B01J2219/00164 ,  B01J2219/1218 ,  B01J2219/1239 ,  B01J2219/126 ,  H05B6/6408 ,  H05B6/806

    摘要： A controlled-flow microwave instrument is disclosed for chemical synthesis using heterogeneous or highly viscous starting materials. The instrument includes a microwave source (10) for generating electromagnetic radiation in the microwave frequencies, a microwave cavity (11) in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel (13) in the cavity, a source reservoir (15) for starting materials and related compositions, a pump (17) in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve (34) between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressures generated therein.

    摘要翻译： 公开了一种控制流动的微波仪器，用于使用不均匀或高粘度起始材料进行化学合成。 该仪器包括用于产生微波频率中的电磁辐射的微波源（10），与该源波形连通的微波腔（11），用于将放置在其中的组合物暴露于微波辐射，微波透明耐压反应容器（13） 在腔体中，用于起始材料和相关组合物的源储存器（15），与源储存器连通的泵（17），用于将不均匀或高粘度材料从源储存器泵送到反应容器，以及耐压阀 （34），用于在向容器中的组合物施加微波能量期间从反应容器与泵和源储存器隔离，以及从其中产生的任何产生的高压中分离反应容器。

    Microwave-assisted peptide synthesis
    3.
    发明公开
    Microwave-assisted peptide synthesis 有权
    MikrowellenunterstütztePeptidsynthese

    公开(公告)号：EP1533025A2

    公开(公告)日：2005-05-25

    申请号：EP05101287.0

    申请日：2004-06-23

    申请人： CEM Corporation

    发明人： Collins, Jonathan Mckinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

    IPC分类号： B01J19/12 ,  C07K1/04

    CPC分类号： B01J19/126 ,  B01J19/087 ,  B01J2219/0871 ,  B01J2219/0879 ,  B01J2219/1206 ,  B01J2219/1209 ,  B01J2219/1215 ,  B01J2219/1218 ,  B01J2219/1221 ,  B01J2219/1254 ,  B01J2219/126 ,  B01J2219/1272 ,  B01J2219/1293 ,  C07K1/045 ,  C07K1/063 ,  C07K5/08 ,  C07K7/06

    摘要： A vessel system for accelerating the solid phase synthesis of peptides comprises a vessel system for the accelerated synthesis of peptides by the solid phase method, said vessel system comprising:

    a reaction cell or vessel (45) that is transparent to microwave radiation;
    a first passageway (46) in fluid communication with said cell (45) for transferring solid phase resin between a resin source external to said cell and said cell;
    a second passageway (47) in fluid communication between at least one amino acid source and said cell (45) for adding amino acids to said cell;
    a third passageway (50) in gaseous communication with an inert gas source (70) and with a vent (71) for applying gas pressure to and releasing gas pressure from said cell (45) so that the controlled flow of gases to and from said cell can be used to add and remove fluids and flowing solids to and from said cell (45).

    摘要翻译： 用于加速肽的固相合成的容器系统包括用于通过固相方法加速合成肽的容器系统，所述容器系统包括：对微波辐射透明的反应池或容器（45）; 与所述电池（45）流体连通的第一通道（46），用于在所述电池外部的树脂源和所述电池之间输送固相树脂; 至少一个氨基酸源和所述细胞（45）之间流体连通的第二通道（47），用于向所述细胞添加氨基酸; 与惰性气体源（70）气态连通的第三通道（50）和用于向所述电池（45）施加气体压力并释放气体压力的通气口（71），以使所述气体与所述气体源 细胞可用于添加和去除流体并将固体流入和从所述细胞（45）流出。

    Method and apparatus for the microwave-assisted peptide synthesis
    5.
    发明公开
    Method and apparatus for the microwave-assisted peptide synthesis 无效
    Verfahren und Vorrichtung zurmikrowellenunterstütztenPeptidsynthese

    公开(公告)号：EP1491552A2

    公开(公告)日：2004-12-29

    申请号：EP04253742.3

    申请日：2004-06-23

    申请人： CEM Corporation

    发明人： Collins, Jonathan McKinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

    IPC分类号： C07K1/04 ,  B01J19/12 ,  H05B6/80

    CPC分类号： B01J19/126 ,  B01J19/087 ,  B01J2219/0871 ,  B01J2219/0879 ,  B01J2219/1206 ,  B01J2219/1209 ,  B01J2219/1215 ,  B01J2219/1218 ,  B01J2219/1221 ,  B01J2219/1254 ,  B01J2219/126 ,  B01J2219/1272 ,  B01J2219/1293 ,  C07K1/045 ,  C07K1/063 ,  C07K5/08 ,  C07K7/06

    摘要： An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid (10) linked to a solid phase resin (14) by admixing the protected linked acid (10) with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid (20) by adding the second acid (20) and an activating solution (22) to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid (20) to the first acid (10) while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin (14) by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

    摘要翻译： 公开了用于加速肽的固相合成的仪器和方法。 该方法包括以下步骤：通过将保护的连接酸（10）与去保护溶液混合在微波透明容器中，同时将混合的酸和溶液同时照射与固相树脂（14）连接的受保护的第一氨基酸（10） 微波，然后通过在向微波炉照射容器的同时向同一容器中加入第二酸（20）和活化溶液（22）来激活第二个氨基酸（20），然后将第二个氨基酸（20）与第一个酸 （10），同时用微波在同一容器中照射组合物，并通过将相连的肽与裂解组合物混合在同一容器中，同时用微波照射组合物，将连接的肽从固相树脂（14）切割。

    Microwave-Assisted Peptide Synthesis
    6.
    发明公开
    Microwave-Assisted Peptide Synthesis 有权
    微波辅助的肽合成

    公开(公告)号：EP1923396A3

    公开(公告)日：2010-03-17

    申请号：EP07117617.6

    申请日：2007-10-01

    申请人： CEM Corporation

    发明人： Collins, Jonathan McKinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

    IPC分类号： C07K1/04 ,  B01J19/12

    CPC分类号： C07K1/045 ,  B01J19/126 ,  B01J2219/00063 ,  B01J2219/00164

    摘要： An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column (43) in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway (46) for adding starting compositions to the column, a second passageway (47) for removing compositions from the column, and a third passageway (50) for circulating compositions from the column into the third passageway and back to the column.

    Microwave-Assisted Peptide Synthesis
    7.
    发明公开
    Microwave-Assisted Peptide Synthesis 有权
    MikrowellenunterstütztePeptidsynthese

    公开(公告)号：EP1923396A2

    公开(公告)日：2008-05-21

    申请号：EP07117617.6

    申请日：2007-10-01

    申请人： CEM Corporation

    发明人： Collins, Jonathan McKinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

    IPC分类号： C07K1/04 ,  B01J19/12

    CPC分类号： C07K1/045 ,  B01J19/126 ,  B01J2219/00063 ,  B01J2219/00164

    摘要： An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column (43) in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway (46) for adding starting compositions to the column, a second passageway (47) for removing compositions from the column, and a third passageway (50) for circulating compositions from the column into the third passageway and back to the column.

    摘要翻译： 公开了通过固相法加速合成肽的仪器和相关方法。 该仪器包括微波腔，与空腔连通的微波源，在由微波辐射透明的材料形成的空腔中的柱（43），柱中的固相肽支撑树脂，用于保持 柱中的固相支撑树脂，用于将起始组合物添加到塔中的第一通道（46），用于从塔中除去组合物的第二通道（47）和用于将组合物从塔中循环到 第三条通道并返回列。

    Microwave-Assisted Peptide Synthesis
    8.
    发明授权
    Microwave-Assisted Peptide Synthesis 有权
    微波辅助的肽合成

    公开(公告)号：EP1923396B1

    公开(公告)日：2013-11-20

    申请号：EP07117617.6

    申请日：2007-10-01

    申请人： CEM Corporation

    发明人： Collins, Jonathan McKinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

    IPC分类号： C07K1/04 ,  B01J19/12

    CPC分类号： C07K1/045 ,  B01J19/126 ,  B01J2219/00063 ,  B01J2219/00164

    摘要： An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column (43) in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway (46) for adding starting compositions to the column, a second passageway (47) for removing compositions from the column, and a third passageway (50) for circulating compositions from the column into the third passageway and back to the column.