公开(公告)号：EP1684703A2

公开(公告)日：2006-08-02

申请号：EP04810444.2

申请日：2004-11-05

申请人： CENTOCOR, INC.

发明人： YAN, Li ,  NAKADA, Marian T ,  DAS, Anuk

IPC分类号： A61K8/18

CPC分类号： A61K31/573 ,  A61K31/137 ,  A61K31/445 ,  A61K31/473 ,  A61K38/00 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/73 ,  A61K2300/00

摘要： The present invention relates to methods for treating at least one MCP-1 related condition or pathology, including therapeutic compositions, methods and devices.

公开(公告)号：EP1888114A2

公开(公告)日：2008-02-20

申请号：EP06770770.3

申请日：2006-05-19

申请人： CENTOCOR INC.

发明人： DAS, Anuk ,  SWEET, Raymond ,  TSUI, Ping ,  BARDROFF, Michael

IPC分类号： A61K39/395

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to at least one novel anti-MCP-1 antibody, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

公开(公告)号：EP1497423A2

公开(公告)日：2005-01-19

申请号：EP03721448.3

申请日：2003-03-24

申请人： Centocor, Inc.

发明人： HEAVNER, George, A. ,  DAS, Anuk

IPC分类号： C12N15/09 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/04 ,  A61K39/00

CPC分类号： C07K14/523 ,  A61K2039/505 ,  C07K16/24

摘要： The present invention relates to at least one novel MCP-1 mutant proteins, antibodies, including isolated nucleic acids that encode at least one MCP-1 mutant protein or antibody, MCP-1 mutant vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including herapeutic compositions, methods and devices.

公开(公告)号：EP1784425A2

公开(公告)日：2007-05-16

申请号：EP05857483.1

申请日：2005-06-29

申请人： CENTOCOR INC.

发明人： DAS, Anuk ,  CARTON, Jill, M

IPC分类号： C07K16/00 ,  C07H21/04 ,  C12N1/20 ,  A61K39/395

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to at least one novel anti-MCP-1 antibodies, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

公开(公告)号：EP2021016A2

公开(公告)日：2009-02-11

申请号：EP07761002.0

申请日：2007-04-20

申请人： CENTOCOR, INC.

发明人： BUGELSKI, Peter ,  DAS, Anuk ,  GRISWOLD, Donald E. ,  LIANG, Bailin ,  LI, Li ,  SARISKY, Robert A. ,  SHANG, Xiaozhou

IPC分类号： A61K38/28

CPC分类号： C07K16/241 ,  A61K2039/507 ,  C07K16/24 ,  C07K2317/76

摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.

公开(公告)号：EP1824514A2

公开(公告)日：2007-08-29

申请号：EP05852564.3

申请日：2005-11-30

申请人： CENTOCOR, INC.

发明人： CARTON, Jill ,  CUNNINGHAM, Mark ,  DAS, Anuk ,  DUFFY, Karen ,  KNIGHT, David, M. ,  LAMB, Roberta ,  MBOW, Mouhamadou, L. ,  RAGHUNATHAN, Gopalan ,  SAN MATEO, Lani ,  SARISKY, Robert, T. ,  STOWELL, Nicole ,  SWEET, Raymond ,  ZHAO, Shanrong ,  CHEN, Shizhong ,  GILES-KOMAR, Jill ,  PICHA, Kristen ,  STOJANOVIC-SUSULIC, Vedrana ,  GOLETZ, Theresa, J.

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.

公开(公告)号：EP1620070A2

公开(公告)日：2006-02-01

申请号：EP04751272.8

申请日：2004-04-29

申请人： CENTOCOR, INC.

发明人： BASSIRI, Ashlyn ,  DAS, Anuk ,  DILLON, Susan ,  DUFFY, Karen ,  SEIDEMAN, Jonathan ,  KARLSSON, Lars ,  SIQUAN, Sun ,  ZHU, Jian ,  MBOW, M., Lamine

IPC分类号： A61K9/00

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K2317/34 ,  C07K2319/30 ,  C07K2319/32

摘要： Cell surface TLR9 and TLR9 ligand binding agents are disclosed. The binding agents include antibodies and other proteins. The binding agents are useful as therapeutics, diagnostics or research reagents.