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1.发明公开OXYTOCIN RECEPTOR ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF PULMONARY RELATED DISEASES 审中-公开催产素受体拮抗剂和它们用于肺病治疗
公开(公告)号：EP1819346A2
公开(公告)日：2007-08-22
申请号：EP05853414.0
申请日：2005-12-08
发明人： HUANG, Chong , SYED, Farhat , LI, Li , LI, Xilin , ARNDT, Gregory , POND, Susan
IPC分类号： A61K31/70 , A61K38/00 , A61K39/395 , C07K7/16 , C07K16/28
CPC分类号： C07K16/286 , A61K2039/505
摘要： Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD.
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2.发明公开CXCL13 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权CXCL-13拮抗剂和TNF-α拮抗剂联合使用治疗
公开(公告)号：EP2021016A2
公开(公告)日：2009-02-11
申请号：EP07761002.0
申请日：2007-04-20
申请人： CENTOCOR, INC.
发明人： BUGELSKI, Peter , DAS, Anuk , GRISWOLD, Donald E. , LIANG, Bailin , LI, Li , SARISKY, Robert A. , SHANG, Xiaozhou
IPC分类号： A61K38/28
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
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公开(公告)号：EP1943359A2
公开(公告)日：2008-07-16
申请号：EP06815683.5
申请日：2006-09-29
申请人： CENTOCOR, INC.
发明人： SYED, Farhat , HUANG, Chong, C. , LI, Katherine , LIU, Guihua , LI, Li , SHANG, Xiaozhou
IPC分类号： C12Q1/68 , G01N33/567 , A61K39/395
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6863 , G01N2333/52 , G01N2800/122 , G01N2800/52
摘要： Compositions and methods are provided for measuring and determining biomarkers for IL-13.
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4.发明公开
公开(公告)号：EP1742968A2
公开(公告)日：2007-01-17
申请号：EP05749883.4
申请日：2005-02-22
申请人： CENTOCOR, INC.
发明人： HEAVNER, George, A. , LI, Li
IPC分类号： C07K16/00
CPC分类号： C07K14/5437 , A61K38/00 , A61K2039/505 , C07K16/244 , C07K16/2875 , C07K2317/73
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公开(公告)号：EP1720573A2
公开(公告)日：2006-11-15
申请号：EP05723301.7
申请日：2005-02-18
申请人： CENTOCOR, INC.
发明人： HEAVNER, George, A. , LI, Li , O'NEIL, Karyn
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21
摘要： The present invention relates to compositions and methods for treating at least one IL-13 related condition or pathology, including therapeutic compositions, formulations, methods and devices.
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公开(公告)号：EP2041568A2
公开(公告)日：2009-04-01
申请号：EP07798532.3
申请日：2007-06-14
申请人： Centocor, Inc.
发明人： LI, Li , POPMA, Sicco, H.
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： C07K16/289 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Anti-chemokine monoclonal antibody therapy is provided for the prevention, control or reversal of chronic rejection mediated vascular remodeling, including, e.g., but not limited to MCP-1/CCR2 antagonist antibody therapy for the modulatation of cardiovascular pathologies associated with cardiac graft rejection including intimal thickening, arteritis, fibrosis, and necrosis.
摘要翻译： 提供抗趋化因子单克隆抗体疗法用于预防，控制或逆转慢性排斥介导的血管重塑，包括例如但不限于用于调节与心脏移植排斥相关的心血管病理的MCP-1 / CCR2拮抗剂抗体疗法，包括 内膜增厚，动脉炎，纤维化和坏死。
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7.发明公开
公开(公告)号：EP1578912A2
公开(公告)日：2005-09-28
申请号：EP02793830.7
申请日：2002-10-25
申请人： CENTOCOR, INC.
发明人： HEAVNER, George , LI, Li
IPC分类号： C12N1/00
CPC分类号： C07K14/5437 , A61K38/00
摘要： The present invention relates to at least one novel Mut-IL-13 proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
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8.发明公开DIABETES-RELATED IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSTIONS, METHODS AND USES 审中-公开始发蛋白，组合物，方法和用途糖尿病相关免疫球蛋白
公开(公告)号：EP1494710A2
公开(公告)日：2005-01-12
申请号：EP03714434.2
申请日：2003-03-26
申请人： Centocor, Inc.
发明人： GRISWOLD, Donald, E. , LI, Jian , LI, Li
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/73
摘要： The present invention relates to at least one novel diabetes related human Ig derived protein or specified portion or variant, including isolated nucleic acids that encode at least one diabetes related Ig derived protein or specified portion or variant, diabetes related Ig derived protein or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
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