公开(公告)号：EP1617802A2

公开(公告)日：2006-01-25

申请号：EP04750883.3

申请日：2004-04-30

申请人： CENTOCOR, INC.

发明人： SONG, Xiao-yu, R. ,  HUANG, Chris ,  MA, Keying ,  LIANG, Bailin ,  NASO, Michael

IPC分类号： A61K6/00

CPC分类号： C07K14/47 ,  A61K45/06

摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

公开(公告)号：EP1874351A2

公开(公告)日：2008-01-09

申请号：EP06751915.7

申请日：2006-04-28

申请人： CENTOCOR, INC. ,  Applied Molecular Evolution Inc.

发明人： CHEN, Yan ,  GARDNER, Debra ,  KNIGHT, David, M. ,  LARK, Michael, W. ,  LIANG, Bailin ,  SHEALY, David, J. ,  SONG, Xiao-Yu, R. ,  STOJANOVIC-SUSULIC, Vedrana ,  SWEET, Raymond, W. ,  TAM, Susan, H. ,  WU, Sheng-Jiun ,  YANG, Jing ,  MARQUIS, David, Matthew ,  SMITH, Eric, Michael ,  VASSEROT, Alain, Philippe

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/24

CPC分类号： C07K16/248 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2316/96 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：EP2021016A2

公开(公告)日：2009-02-11

申请号：EP07761002.0

申请日：2007-04-20

申请人： CENTOCOR, INC.

发明人： BUGELSKI, Peter ,  DAS, Anuk ,  GRISWOLD, Donald E. ,  LIANG, Bailin ,  LI, Li ,  SARISKY, Robert A. ,  SHANG, Xiaozhou

IPC分类号： A61K38/28

CPC分类号： C07K16/241 ,  A61K2039/507 ,  C07K16/24 ,  C07K2317/76

摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.