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1.发明公开
公开(公告)号：EP0750508A1
公开(公告)日：1997-01-02
申请号：EP95912306.0
申请日：1995-03-13
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K5/0212 , C07K7/02 , C07K14/47 , Y02A50/386
摘要： The invention discloses the use of (1) peptide compounds in which at least one and advantageously all of the -CO-NH- bonds in the peptide chain of the corresponding parent peptide (comprising no -NH-CO- bond in its peptide chain) is (are) replaced with one or more -NH-CO- bonds, the chirality of every aminoacyl residue, whether or not it contributes to the one or more above-mentioned -NH-CO- bonds, being either maintained or reversed relative to the corresponding aminoacyl residues constituting said parent peptide, said peptide compounds also being known as immunoretroids; or (2) antibodies to said immunoretroids (anti-immunoretroid antibodies); said immunoretroids being capable of forming a complex with said anti-immunoretroid antibodies as well as with antibodies to the parent proteins or peptides (known as anti-parent antibodies), and/or to the enantiomers of such parent proteins or peptides; for preparing a drug which is particularly useful for treating or preventing diseases related to the presence in the body of an individual of an exogenous or endogenous protein capable of being recognised by the above-mentioned anti-parent or anti-immunoretroid antibodies.
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2.发明公开ANALOGUES PEPTIDIQUES COMPRENANT AU MOINS UN RESIDU AZA-BETA 3 AMINOACYLE, ET LEURS UTILISATIONS, NOTAMMENT EN THERAPIE 有权肽类似物至少有一个AMINOACY-AZA-β-3-REST遏制和它们的用途，特别是用于治疗的
公开(公告)号：EP1631586A2
公开(公告)日：2006-03-08
申请号：EP04767332.2
申请日：2004-06-11
IPC分类号： C07K14/47
CPC分类号： A61K39/395 , A61K38/00 , C07C281/02 , C07C323/48 , C07K14/47 , Y02A50/385 , Y02P20/55
摘要： The invention relates to peptide analogues or parent proteins comprising at least one type of aminoacyl aza-β3 residue and to the use thereof for pharmaceutical compositions or for diagnosis of pathologies involving said peptides or parent proteins.
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3.发明授权
公开(公告)号：EP1425295B1
公开(公告)日：2009-12-23
申请号：EP02797690.1
申请日：2002-09-06
发明人： MULLER, Sylviane , MONNEAUX, Fanny , BRIAND, Jean-Paul , GUICHARD, Gille , GUILLET, Jean-Gérard
CPC分类号： C07K14/47 , A61K38/02 , A61K38/16 , A61K39/0008
摘要： Disclosed herein are a modified peptide, compositions containing the same and their use in the treatment of autoimmune diseases. The modified peptide is provided by a chemical modification of at least one of the several amino acid residues comprising the peptide of sequence RIHMUYSKRSGKPRGYAFIEY (seq ID No : 1). The modification is carried out by phosphorylation, acetylation or methylation, or as a combination thereof.
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4.发明公开
公开(公告)号：EP3484864A1
公开(公告)日：2019-05-22
申请号：EP17743287.9
申请日：2017-07-13
申请人： Centre National de la Recherche Scientifique - CNRS , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Strasbourg , Universite Paris-Sud , Centre International de Recherche aux Frontières de la Chimie
发明人： BONNET, Dominique , FROSSARD, Nelly , GALZI, Jean-Luc , GUIGNABERT, Christophe , HIBERT, Marcel , SIMONIN, Frédéric , MULLER, Sylviane
IPC分类号： C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D239/36 , C07D409/04 , C07D413/04 , C07D413/10 , C07D417/04 , A61K31/513 , A61P35/00
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5.发明授权ANALOGUES PEPTIDIQUES COMPRENANT AU MOINS UN RESIDU AZA-BETA 3 AMINOACYLE, ET LEURS UTILISATIONS, NOTAMMENT EN THERAPIE 有权肽类似物至少有一个AMINOACY-AZA-β-3-REST遏制和它们的用途，特别是用于治疗的
公开(公告)号：EP1631586B1
公开(公告)日：2007-08-22
申请号：EP04767332.2
申请日：2004-06-11
IPC分类号： C07K14/47
CPC分类号： A61K39/395 , A61K38/00 , C07C281/02 , C07C323/48 , C07K14/47 , Y02A50/385 , Y02P20/55
摘要： The invention relates to peptide analogues or parent proteins comprising at least one type of aminoacyl aza- beta residue and to the use thereof for pharmaceutical compositions or for diagnosis of pathologies involving said peptides or parent proteins.
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