公开(公告)号：EP3484864A1

公开(公告)日：2019-05-22

申请号：EP17743287.9

申请日：2017-07-13

申请人： Centre National de la Recherche Scientifique - CNRS ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université de Strasbourg ,  Universite Paris-Sud ,  Centre International de Recherche aux Frontières de la Chimie

发明人： BONNET, Dominique ,  FROSSARD, Nelly ,  GALZI, Jean-Luc ,  GUIGNABERT, Christophe ,  HIBERT, Marcel ,  SIMONIN, Frédéric ,  MULLER, Sylviane

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D239/36 ,  C07D409/04 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  A61K31/513 ,  A61P35/00

公开(公告)号：EP0750508A1

公开(公告)日：1997-01-02

申请号：EP95912306.0

申请日：1995-03-13

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： GUICHARD, Gilles ,  MULLER, Sylviane ,  BRIAND, Jean-Paul ,  REGENMORTEL, Marc

IPC分类号： C07K5 ,  C07K7 ,  C07K14 ,  C07K16 ,  A61K38 ,  A61K39

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K39/00 ,  C07K5/0212 ,  C07K7/02 ,  C07K14/47 ,  Y02A50/386

摘要： The invention discloses the use of (1) peptide compounds in which at least one and advantageously all of the -CO-NH- bonds in the peptide chain of the corresponding parent peptide (comprising no -NH-CO- bond in its peptide chain) is (are) replaced with one or more -NH-CO- bonds, the chirality of every aminoacyl residue, whether or not it contributes to the one or more above-mentioned -NH-CO- bonds, being either maintained or reversed relative to the corresponding aminoacyl residues constituting said parent peptide, said peptide compounds also being known as immunoretroids; or (2) antibodies to said immunoretroids (anti-immunoretroid antibodies); said immunoretroids being capable of forming a complex with said anti-immunoretroid antibodies as well as with antibodies to the parent proteins or peptides (known as anti-parent antibodies), and/or to the enantiomers of such parent proteins or peptides; for preparing a drug which is particularly useful for treating or preventing diseases related to the presence in the body of an individual of an exogenous or endogenous protein capable of being recognised by the above-mentioned anti-parent or anti-immunoretroid antibodies.

公开(公告)号：EP1631586A2

公开(公告)日：2006-03-08

申请号：EP04767332.2

申请日：2004-06-11

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BAUDY FLOC'H, Michèle ,  BUSNEL, Olivier ,  MULLER, Sylviane

IPC分类号： C07K14/47

CPC分类号： A61K39/395 ,  A61K38/00 ,  C07C281/02 ,  C07C323/48 ,  C07K14/47 ,  Y02A50/385 ,  Y02P20/55

摘要： The invention relates to peptide analogues or parent proteins comprising at least one type of aminoacyl aza-β3 residue and to the use thereof for pharmaceutical compositions or for diagnosis of pathologies involving said peptides or parent proteins.

公开(公告)号：EP1425295B1

公开(公告)日：2009-12-23

申请号：EP02797690.1

申请日：2002-09-06

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： MULLER, Sylviane ,  MONNEAUX, Fanny ,  BRIAND, Jean-Paul ,  GUICHARD, Gille ,  GUILLET, Jean-Gérard

IPC分类号： C07K2/00 ,  C07K14/00 ,  C07K14/47 ,  A61K38/02 ,  A61K38/16 ,  A61K39/00

CPC分类号： C07K14/47 ,  A61K38/02 ,  A61K38/16 ,  A61K39/0008

摘要： Disclosed herein are a modified peptide, compositions containing the same and their use in the treatment of autoimmune diseases. The modified peptide is provided by a chemical modification of at least one of the several amino acid residues comprising the peptide of sequence RIHMUYSKRSGKPRGYAFIEY (seq ID No : 1). The modification is carried out by phosphorylation, acetylation or methylation, or as a combination thereof.

公开(公告)号：EP1631586B1

公开(公告)日：2007-08-22

申请号：EP04767332.2

申请日：2004-06-11

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BAUDY FLOC'H, Michèle ,  BUSNEL, Olivier ,  MULLER, Sylviane

IPC分类号： C07K14/47

CPC分类号： A61K39/395 ,  A61K38/00 ,  C07C281/02 ,  C07C323/48 ,  C07K14/47 ,  Y02A50/385 ,  Y02P20/55

摘要： The invention relates to peptide analogues or parent proteins comprising at least one type of aminoacyl aza- beta residue and to the use thereof for pharmaceutical compositions or for diagnosis of pathologies involving said peptides or parent proteins.

公开(公告)号：EP2293785B1

公开(公告)日：2012-07-11

申请号：EP09761922.5

申请日：2009-05-20

申请人： Centre National de la Recherche Scientifique (C.N.R.S) ,  Université de Strasbourg

发明人： DANICHER, Louis ,  FRERE, Yves ,  MULLER, Sylviane ,  WAWREZINIECK, Anne

IPC分类号： A61K9/51 ,  A61K38/17 ,  A61P37/00 ,  A61K47/36

CPC分类号： C07K14/4713 ,  A61K9/5161 ,  A61K9/5169 ,  A61K38/00

摘要： The invention relates to nanoparticles comprising a matrix containing at least one polysaccharide as well as the peptide P140 having the sequence SEQ ID NO: 1 or an analog thereof, said polysaccharide preferably being a polysaccharide bearing one or more negatively-charged functional groups. The invention also relates to a carrier for oral administration that comprises a carrier including at least one nanoparticle as defined above and either containing or not containing a dispersant.