公开(公告)号：EP0737248A1

公开(公告)日：1996-10-16

申请号：EP95905172.0

申请日：1994-12-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE

发明人： GIOVANNANGELI, Carine ,  HELENE, Claude

IPC分类号： C12N15 ,  A61K9 ,  A61K31 ,  A61K35 ,  A61K48 ,  A61P31 ,  A61P35 ,  C07H21 ,  C12N7 ,  A61K38

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1132 ,  C12N15/1136 ,  C12N2310/152 ,  C12N2310/53 ,  C12N2310/531 ,  C12N2310/532 ,  Y10S977/802 ,  Y10S977/916 ,  Y10S977/92

摘要： The present invention relates to new vectors, pharmaceutical compositions containing them, and their therapeutical uses. More particularly, it relates to double strand DNA molecules coding for an RNA forming a triple helix with a single strand target nucleic acid. Said molecules act very selectively and efficiently on the expression of genes.

公开(公告)号：EP0737248B1

公开(公告)日：2007-11-14

申请号：EP95905172.3

申请日：1994-12-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE

发明人： GIOVANNANGELI, Carine ,  HELENE, Claude

IPC分类号： C12N15/11 ,  C12N15/86 ,  C07H21/02 ,  A61K31/70

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1132 ,  C12N15/1136 ,  C12N2310/152 ,  C12N2310/53 ,  C12N2310/531 ,  C12N2310/532 ,  Y10S977/802 ,  Y10S977/916 ,  Y10S977/92

公开(公告)号：EP1606405A2

公开(公告)日：2005-12-21

申请号：EP04721540.5

申请日：2004-03-18

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE

发明人： ARIMONDO, Paola Barbara ,  BOUTORINE, Alexandre ,  SUN, Jian-Sheng ,  BAILLY, Christian ,  HELENE, Claude ,  GARESTIER, Thérèse

IPC分类号： C12N15/11 ,  A61K31/7088

CPC分类号： C12N15/1132 ,  A61K38/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1135 ,  C12N15/1136 ,  C12N2310/15 ,  C12N2310/314 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/33 ,  C12N2310/3341 ,  C12N2310/3511 ,  C12N2310/53

摘要： The invention relate to the use of a compound of formula A-B-C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.

公开(公告)号：EP0290583B1

公开(公告)日：1993-04-07

申请号：EP88900022.0

申请日：1987-12-02

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： HELENE, Claude ,  IMBACH, Jean-Louis ,  NGUYEN, Thanh, Thuong ,  PAOLETTI, Claude ,  RAYNER, Bernard Chênes-Colombière, G 68

IPC分类号： C07H21/04

CPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： Chemical compounds comprised of an oligonucleotide or an oligodioxinucleotide. According to the invention, they comprise a chain of nucleotides with an anomeric unnatural alpha configuration. The invention also relates to a chain of alpha nucleotides which is linked by a covalent bond to an effector agent, particularly to an intercalating radical or to a chemical photoactivatable or reactive radical. The invention also relates to an application of the compounds, application according to which they couple in parallel to a complementary sequence of beta oligonucleotides. These compounds are usable as probes or as artifical nucleases specific of sequences of nucleic acids. They may be used to selectively lock the expression of a previously selected gene by acting either on the genetic information or on the messenger RNAs.

摘要翻译： 由寡核苷酸或寡核苷酸组成的化学化合物。 根据本发明，它们包含具有异头非天然α构型的核苷酸链。 本发明还涉及通过共价键连接至效应剂，特别是嵌入基团或化学可光活化或反应性基团的α核苷酸链。 本发明还涉及这些化合物的应用，据此它们与β寡核苷酸的互补序列平行偶联。 这些化合物可用作探针或核酸序列特异性的人工核酸酶。 它们可用于通过作用于遗传信息或信使RNA来选择性地锁定先前选择的基因的表达。

公开(公告)号：EP1307452A1

公开(公告)日：2003-05-07

申请号：EP01958203.0

申请日：2001-07-30

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE

发明人： MERGNY, Jean-Louis ,  LACROIX, Laurent ,  TEULADE-FICHOU, Marie-Paule ,  VIGNERON, Jean-Pierre ,  LEHN, Jean-Marie ,  HELENE, Claude

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P35/00 ,  C07D221/00

CPC分类号： C07D471/04

摘要： The invention concerns the use of aromatic compounds capable of binding with G-quadruplex structures to produce medicines with anti-telomerase effect. Said compounds correspond to formula (I) wherein: R1, R2 and R3, identical or different, represent a hydrogen atom, or a -CH2-NH-(CH2)n-X group, wherein n is an integer from 2 to 4, and X is selected among -NH2-, -N(CH3)2 radicals, a heterocyclic radical such as piperidyl, imidazolyl, morpholinyl radical, or an indole-type condensed heterocyclic radical, -Z represents CH or N, each compound comprising two nitrogen atoms in the Z positions. The invention is useful for producing anticancer medicines.