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公开(公告)号：EP1756579B1
公开(公告)日：2010-03-03
申请号：EP05778653.5
申请日：2005-06-15
发明人： HIBERT, Marcel, François, Louis , FRANCHET, Christel, Anne , GALZI, Jean-Luc , PATTUS, Franc, Emile, Jean , GUILLIER, Fabrice, Yves
IPC分类号： G01N33/58 , G01N33/543 , G01N33/566 , C07K1/13
CPC分类号： G01N33/54353 , C07K5/0817 , C07K5/0827 , C07K5/1019 , C07K5/1027 , G01N33/566 , G01N33/582 , G01N2333/726 , G01N2500/04
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公开(公告)号：EP1756579A2
公开(公告)日：2007-02-28
申请号：EP05778653.5
申请日：2005-06-15
发明人： HIBERT, Marcel, François, Louis , FRANCHET, Christel, Anne , GALZI, Jean-Luc , PATTUS, Franc, Emile, Jean , GUILLIER, Fabrice, Yves
IPC分类号： G01N33/58 , G01N33/543 , G01N33/566 , C07K1/13
CPC分类号： G01N33/54353 , C07K5/0817 , C07K5/0827 , C07K5/1019 , C07K5/1027 , G01N33/566 , G01N33/582 , G01N2333/726 , G01N2500/04
摘要： The invention concerns the use of a collection of traceable cationic compounds for determining ligands of a receptor whose ligand is unknown or whose ligand useful for specific affinity binding studies is unknown, said traceable cationic compounds being characterized in that they comprise at least one basic amino acid residue providing the cationic type to said compound and a tracer group, in particular a fluorophor, a colouring agent or a quencher.
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公开(公告)号：EP1756119A1
公开(公告)日：2007-02-28
申请号：EP05778643.6
申请日：2005-06-15
发明人： HIBERT, Marcel, François, Louis , FRANCHET, Christel, Anne , GALZI, Jean-Luc , PATTUS, Franc, Emile, Jean , GUILLIER, Fabrice, Yves
IPC分类号： C07D497/10 , C07D295/14 , C07D277/40 , C07D241/26 , C07D213/56 , C07D207/16
CPC分类号： C07D497/10 , Y02P20/55
摘要： The invention concerns the use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R'1 represent in particular a hydrogen atom; R2 represents an amino acid side chain or an amino acid derivative; R3 represents a group derived from a carboxylic acid, bearing a basic entity; R4 represents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a colouring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.
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公开(公告)号：EP1756119B1
公开(公告)日：2007-10-10
申请号：EP05778643.6
申请日：2005-06-15
发明人： HIBERT, Marcel, François, Louis , FRANCHET, Christel, Anne , GALZI, Jean-Luc , PATTUS, Franc, Emile, Jean , GUILLIER, Fabrice, Yves
IPC分类号： C07D497/10 , C07D295/14 , C07D277/40 , C07D241/26 , C07D213/56 , C07D207/16
CPC分类号： C07D497/10 , Y02P20/55
摘要： The invention concerns the use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R'1 represent in particular a hydrogen atom; R2 represents an amino acid side chain or an amino acid derivative; R3 represents a group derived from a carboxylic acid, bearing a basic entity; R4 represents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a colouring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.
摘要翻译： 本发明涉及一组通式（I）化合物的用途，其中：n是0或1; p表示1和6之间的整数; r代表1和12之间的整数; R1和R1'特别代表氢原子; R2代表氨基酸侧链或氨基酸衍生物; R3代表衍生自具有碱性实体的羧酸的基团; R4特别表示含有1至10个碳原子的烷基; A代表氢原子，保护基团或示踪基团，特别是荧光团，着色剂或猝灭剂，用于通过结合研究确定配体未知或其配体可用于进行特异性亲和力的受体的配体 结合分析未知。
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