-
公开(公告)号：EP2069312A2
公开(公告)日：2009-06-17
申请号：EP07810758.8
申请日：2007-07-25
申请人： Cephalon, Inc.
发明人： HUDKINS, Robert, L. , JOSEF, Kurt, A. , TAO, Ming , BECKNELL, Nadine, C. , HOSTETLER, Greg , KNUTSON, Lars, J., S. , ZULLI, Allison, L.
IPC分类号： C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D403/04 , C07D403/12 , C07D495/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61P25/28
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供了式（I *）的化合物：其作为H3抑制剂的用途，其制备方法及其药物组合物。
-
公开(公告)号：EP1206473B1
公开(公告)日：2004-10-20
申请号：EP00954136.8
申请日：2000-08-18
申请人： CEPHALON, INC.
发明人： HUDKINS, Robert, L.
IPC分类号： C07D487/04 , A61K31/407 , A61K31/437 , A61P13/08 , A61P35/00 , A61P25/00 , C07D495/14 , C07D491/14 , C07D471/14
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14 , C07D495/14
摘要： The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, having activity toward trk kinase, platelet derived growth factor receptor (PDGFR) kinase, vascular endothelial growth factor receptor (VEGFR) kinase, NGF-stimulated trk phosphorylation, or tropic factor responsive cells.
-
公开(公告)号：EP1083903B1
公开(公告)日：2004-08-25
申请号：EP99927234.7
申请日：1999-06-04
申请人： CEPHALON, INC.
发明人： SINGH, Jasbir , HUDKINS, Robert, L. , MALLAMO, John, P. , UNDERINER, Theodore, L. , TRIPATHY, Rabindranath
IPC分类号： A61K31/55 , C07D498/22
CPC分类号： C07D498/22
摘要： The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.
-
公开(公告)号：EP1044203B1
公开(公告)日：2003-03-12
申请号：EP98964309.3
申请日：1998-12-30
IPC分类号： C07D498/22 , A61K31/55 , C07H7/06
CPC分类号： C07D498/22 , C07H5/06
摘要： Compounds defined by general structure (II) are disclosed. These compounds display pharmacological activities, including inhibition of tyrosine kinase activity and enhancement of the function and/or survival of trophic factor responsive cells, e.g., cholinergic neurons.
摘要翻译： 公开了由通式结构（II）定义的化合物。 这些化合物显示出药理学活性，包括抑制酪氨酸激酶活性和增强营养因子应答细胞（例如胆碱能神经元）的功能和/或存活。
-
5.发明公开FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON 失效简明吡咯并（2,3-C）咔唑-6-酮γ-干扰素增强的活性
公开(公告)号：EP0885229A1
公开(公告)日：1998-12-23
申请号：EP97914792.0
申请日：1997-02-20
申请人： CEPHALON, INC.
CPC分类号： C07D487/04 , C07D487/14 , C07D493/14 , C07D495/14
摘要： Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo(2,3-c)carbazole-6-ones. These molecules are represented by general formulae (I) and (II). Methods for making and using the fused pyrrolo(2,3-c)carbazole-6-ones are also disclosed.
-
公开(公告)号：EP2069312B1
公开(公告)日：2012-11-07
申请号：EP07810758.8
申请日：2007-07-25
申请人： Cephalon, Inc.
发明人： HUDKINS, Robert, L. , JOSEF, Kurt, A. , TAO, Ming , BECKNELL, Nadine, C. , HOSTETLER, Greg , KNUTSEN, Lars, J., S. , ZULLI, Allison, L.
IPC分类号： C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D403/04 , C07D403/12 , C07D495/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61P25/28
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
-
7.发明公开SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开比组胺-3（H 3）受体的配体取代的哒嗪酮衍生物
公开(公告)号：EP2328586A2
公开(公告)日：2011-06-08
申请号：EP09750963.2
申请日：2009-05-20
申请人： Cephalon, Inc.
发明人： BECKNELL, Nadine, C. , DANDU, Reddeppareddy , DUNN, Derek, D. , HUDKINS, Robert, L. , JOSEF, Kurt, A. , SUNDAR, Babu, G. , ZULLI, Allison, L.
IPC分类号： A61K31/55 , C07D403/02
CPC分类号： C07D403/04 , C07D237/14 , C07D401/14 , C07D403/10 , C07D403/12 , C07D487/04
摘要： The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H
3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.-
8.发明公开SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 有权取代的螺环哌啶衍生物比组胺-3（H 3）受体的配体
公开(公告)号：EP2257553A1
公开(公告)日：2010-12-08
申请号：EP09706445.5
申请日：2009-01-28
申请人： Cephalon, Inc.
IPC分类号： C07D491/10 , A61K31/501 , A61P25/00
CPC分类号： C07D491/113 , C07D491/10 , C07D491/107
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
-
9.发明公开
公开(公告)号：EP2252593A1
公开(公告)日：2010-11-24
申请号：EP09706750.8
申请日：2009-01-28
申请人： Cephalon, Inc.
发明人： HUDKINS, Robert, L. , KNUTSEN, Lars, J.S. , PROUTY, Catherine, P. , SUNDAR, Babu, G. , WELLS-KNECHT, Kevin, J.
IPC分类号： C07D237/08 , C07D237/12 , C07D237/14 , C07D237/18 , C07D237/20 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04 , A61K31/50 , A61K31/501 , A61K31/502 , A61P25/00
CPC分类号： C07D237/12 , C07D237/08 , C07D237/14 , C07D237/18 , C07D237/20 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.
-
10.发明公开MULTICYCLIC COMPOUNDS AND THE USE THEREOF AS INHIBITORS OF PARP, VEGFR2 AND MLK3 ENZYMES 有权多循环化合物及其作为PARP，VEGFR2和MLK3酶抑制剂
公开(公告)号：EP1294725A2
公开(公告)日：2003-03-26
申请号：EP01935215.2
申请日：2001-05-09
申请人： CEPHALON, INC.
IPC分类号： C07D487/04 , A61K31/395 , A61P43/00 , C07D519/00 , C07D491/14 , C07D471/14
CPC分类号： C07D491/04 , C07D471/14 , C07D487/04 , C07D491/14 , C07D495/04
摘要： The present invention is directed to novel multicyclic molecules of formula (Ia) that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.027 秒)
