公开(公告)号：EP3858832A1

公开(公告)日：2021-08-04

申请号：EP19878278.1

申请日：2019-10-29

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： LIU, Fei ,  FENG, Weiwei ,  WANG, Bin ,  XU, Hongjiang ,  WANG, Jinan ,  ZHANG, Xiquan ,  WANG, Shanchun ,  LIU, Yanlong ,  ZHANG, Jianqing ,  YAO, Yiyan ,  TANG, Xujing ,  SHI, Wei ,  ZHANG, Hongying ,  LI, Yang ,  TANG, Song ,  ZHU, Yizhong ,  LIU, Limin ,  GU, Hongmei ,  YANG, Ling

IPC分类号： C07D471/04 ,  C07D211/96 ,  C07D215/20 ,  A61K31/404 ,  A61P35/00

摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

公开(公告)号：EP3978494A1

公开(公告)日：2022-04-06

申请号：EP20813454.4

申请日：2020-05-22

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

发明人： LIU, Fei ,  LIU, Yanlong ,  XU, Hongjiang ,  ZHANG, Xiquan ,  WANG, Shanchun ,  ZHANG, Jianqing ,  FENG, Weiwei ,  WANG, Bin ,  WANG, Jinan ,  WANG, Yubing ,  TANG, Xujing ,  NIE, Quandeng

IPC分类号： C07D471/04 ,  C07D211/96 ,  C07D215/20 ,  A61K31/404 ,  A61P35/00

摘要： Disclosed is a methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor; specifically disclosed are a compound of formula I, a stereoisomer or pharmaceutically acceptable salt of same, a preparation method therefor, and a pharmaceutical composition comprising the compound. Also disclosed are uses of the compound and of the pharmaceutical composition comprising the compound in treating anti-apoptotic protein BCL-2-related diseases such as cancer.

公开(公告)号：EP4289833A1

公开(公告)日：2023-12-13

申请号：EP22749196.6

申请日：2022-01-30

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

发明人： LIU, Fei ,  LIU, Yanlong ,  WANG, Bin ,  XU, Hongjiang ,  TANG, Xujing

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/501 ,  A61P29/00 ,  A61P37/00

摘要： A TYK2 inhibitor compound containing a bicyclic ring and the use thereof in the preparation of a drug for treating or preventing TYK2-related diseases.