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    Primycin solutions
    1.
    发明公开
    Primycin solutions 失效
    伯霉素Lösungen。

    公开(公告)号：EP0367586A1

    公开(公告)日：1990-05-09

    申请号：EP89311289.6

    申请日：1989-11-01

    申请人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

    发明人： Szentmiklosi, Peter ,  Szuts, Tamas ,  Hidasi, Gyorgy ,  Juhasz, Istvan

    IPC分类号： A61K31/71 ,  A61K9/08 ,  A61K47/18 ,  A61K7/48

    CPC分类号： A61K31/70 ,  A61K8/602 ,  A61K9/0014 ,  A61K47/22 ,  A61K47/54 ,  A61K2800/52 ,  A61Q17/005

    摘要： The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin with N-methylpirrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-­-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 600% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount supplementing up to 100%.
    The invention further relates to pharmaceutical or disinfecting cosmetic compositions mainly for topical treatment containing the above primycin solution optionally in admixture with pharmaceutically acceptable auxiliary materials and, if desired. with other non-synergistic therapeutically active ingredient(s), suitably desquamating and/or antiinflammatory agent(s).
    The invention further relates to the preparation of the above primycin solutions and compositions containing these solutions.

    摘要翻译： 本发明涉及含有0.5〜1.75质量％/体积的硫酸伯霉素或2.5〜9质量％的伯霉素与N-甲基吡咯烷酮复合物和2〜15质量％体积的焦谷氨酸的新型稳定含水伯霉素溶液 酸，优选L-焦谷氨酸或可溶性盐，优选其钠盐，按制备溶液的体积计算，40至600体积％异丙醇，按制备溶液的体积计算为 以及补充量达100％的水。 本发明还涉及药物或消毒化妆品组合物，其主要用于局部治疗，其含有上述的伯霉素溶液，任选与药学上可接受的辅助材料混合，如果需要。 与其他非协同治疗活性成分，适合脱屑和/或抗炎剂。 本发明还涉及上述含有这些溶液的伯霉素溶液和组合物的制备。