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1.发明公开RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACROMOLECULAR SYNTHESIS 审中-公开随着蜂窝大分子合成减少缓蚀ALPHA病毒的载体
公开(公告)号：EP1029068A2
公开(公告)日：2000-08-23
申请号：EP98953276.7
申请日：1998-10-06
发明人： DUBENSKY, Thomas, W., Jr. , POLO, John, M. , BELLI, Barbara, A. , SCHLESINGER, Sondra , DRYGA, Sergey, A. , FROLOV, Ilya
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
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2.发明公开RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACROMOLECULAR SYNTHESIS 失效与合成细胞的大分子减少的抑制ALPHA病毒载体
公开(公告)号：EP0907746A2
公开(公告)日：1999-04-14
申请号：EP97922294.0
申请日：1997-04-04
发明人： DUBENSKY, Thomas, W., Jr. , POLO, John, M. , BELLI, Barbara, A. , SCHLESINGER, Sondra , DRYGA, Sergey A. , FROLOV, Ilya
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/003 , C12N2830/006 , C12N2830/15 , C12N2830/32 , C12N2830/42 , C12N2830/48 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
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公开(公告)号：EP1071454A1
公开(公告)日：2001-01-31
申请号：EP99919976.3
申请日：1999-04-23
发明人： RICE, Charles, M. , FROLOV, Ilya , McBRIDE, M., Scott , LEE, Young-min , AGAPOV, Eugene, V. , MYERS, Tina, M.
IPC分类号： A61K39/29 , A61K39/295 , C12Q1/70 , C12N7/01 , C07H21/02
CPC分类号： C07K14/005 , A61K2039/5256 , C12N2770/24222 , C12N2770/24322
摘要： Disclosed is a polynucleotide comprising a chimeric viral RNA which contains: a 5' nontranslated region (5' NTR), an open reading frame (ORF) region, and a 3' nontranslated region (3' NTR) wherein at least one of said regions is chimeric. The chimeric region comprises a first nucleotide sequence from a pestivirus in operable linkage with a heterologous nucleotide sequence. The chimeric viral RNA is replication-competent. Preferably the pestivirus sequence is from a bovine viral diarrhea virus and the heterologous nucleotide sequence is from a hepatitis C virus. Also disclosed are a method for identifying compounds having antiviral activity agaisnt hepatitis C virus, a genetically-engineered chimeric RNA virus and a vaccine against bovine viral diarrhea virus.
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4.发明授权RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACROMOLECULAR SYNTHESIS 失效与合成细胞的大分子减少的抑制ALPHA病毒载体
公开(公告)号：EP0907746B1
公开(公告)日：2008-02-20
申请号：EP97922294.0
申请日：1997-04-04
发明人： DUBENSKY, Thomas, W., Jr. , POLO, John, M. , BELLI, Barbara, A. , SCHLESINGER, Sondra , DRYGA, Sergey A. , FROLOV, Ilya
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/003 , C12N2830/006 , C12N2830/15 , C12N2830/32 , C12N2830/42 , C12N2830/48 , C12N2840/203 , C12N2840/44
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5.发明公开COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE UTILIZING ALPHAVIRUS-BASED VECTOR SYSTEMS 有权基于部署的免疫反应的组合物和方法ALPHA病毒载体系统
公开(公告)号：EP1175497A2
公开(公告)日：2002-01-30
申请号：EP00923558.1
申请日：2000-04-14
申请人： CHIRON CORPORATION
发明人： POLO, John, M. , DUBENSKY, Thomas, W., Jr. , FROLOV, Ilya , GARDNER, Jason, P. , OTTEN, Gillis , BARNETT, Susan , DRIVER, David, A.
CPC分类号： C07K14/005 , A61K35/00 , A61K2039/5256 , C12N15/86 , C12N2740/16122 , C12N2770/36143
摘要： Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
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