公开(公告)号：EP1304573A4

公开(公告)日：2006-06-07

申请号：EP01950013

申请日：2001-07-17

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： YABUTA NAOHIRO ,  ADACHI HIDEKI ,  SHIMONAKA YASUSHI ,  HATTORI KUNIHIRO

IPC分类号： G01N33/50 ,  G01N33/566 ,  C12N5/00 ,  C12N15/00 ,  G01N33/15

CPC分类号： G01N33/566 ,  G01N2500/00

摘要： A method for identifying a compound having at least one of two or more objective biological activities, which comprises providing a test method using the same index for detecting each of above-mentioned one or more biological activities and measuring one or more specimens by the test method. The method can be used for detecting a compound having at least one of two or more biological activities with good efficiency and with ease and simplicity. The specimens being positive with respect to the above test are further tested by a method using a specific test for detecting each objective biological activity and, as a result, a specimen having a specific objective biological activity can be identified by screening with good efficiency and with ease and simplicity.

公开(公告)号：EP1069185A4

公开(公告)日：2005-01-19

申请号：EP99912098

申请日：1999-04-02

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： SATO KOH ,  ADACHI HIDEKI ,  YABUTA NAOHIRO

IPC分类号： C07K16/28 ,  C07K16/36 ,  C12N15/13 ,  C12P21/08 ,  C12N5/10

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

摘要： A humanized antibody against tissue factor (TF) which comprises: A. a humanized H chain containing (1) an H chain V region containing the H chain CDR of a mouse monoclonal antibody against TF and the H chain FR of a human antibody, and (2) the H chain C region of a human antibody; and B. a humanized L chain containing (1) an L chain V region containing the L chain CDR of a mouse monoclonal antibody against TF and the L chain FR of a human antibody, and (2) the L chain C region of a human antibody. The mouse monoclonal antibody CDR is grafted into the human antibody to construct the humanized V region. Next, the FR thereof is replaced by the corresponding FR of another human antibody with a high homology, thus detecting a highly active humanized antibody.

公开(公告)号：EP2047863A4

公开(公告)日：2009-12-09

申请号：EP07744945

申请日：2007-06-08

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： HASEGAWA MASAKAZU ,  KITAMURA HIDETOMO ,  ADACHI HIDEKI ,  KASUTANI KEIKO

IPC分类号： A61K45/00 ,  A61K39/395 ,  A61P1/04 ,  A61P1/16 ,  A61P11/06 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07K16/28 ,  C12N15/02

CPC分类号： C07K16/2866 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/715 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00

公开(公告)号：EP1393624A4

公开(公告)日：2006-10-18

申请号：EP02771571

申请日：2002-05-17

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： HABU KIYOSHI ,  JISHAGE KOU-ICHI ,  ADACHI HIDEKI ,  YABUTA NAOHIRO

IPC分类号： A01K67/027 ,  C12N15/09 ,  C12N15/85 ,  G01N33/15 ,  G01N33/50

CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N2800/30

摘要： A knockin nonhuman animal having genome wherein a cDNA encoding a human tissue factor is inserted in the upstream of the initiation codon of a nonhuman animal genome tissue factor gene and producing not the nonhuman animal tissue factor but the human tissue factor.