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公开(公告)号：EP0974648A4
公开(公告)日：2002-11-20
申请号：EP98905787
申请日：1998-03-06
发明人： KITAMURA HIDETOMO
CPC分类号： G01N33/5073 , C12N5/0663 , C12N2503/02 , G01N33/5008 , G01N33/502 , G01N33/5026 , G01N33/5088
摘要： A cloned cell line of undifferentiated mesenchymal cells, capable of differentiating into chondrocytes and adipocytes and established from a normal matured animal; and a method for screening cell differentiation regulators. Specifically, a cell line capable of differentiating into chondrocytes and adipocytes and characterized by originating in a normal matured animals; a method for screening cell differentiation regulators by using the above cell line; screening kits containing the above cell line; cell differentiation regulators obtained by the above screening method; and drugs containing the above differentiation regulators.
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2.发明公开PREVENTIVES OR REMEDIES FOR PSORIASIS CONTAINING AS THE ACTIVE INGREDIENT IL-6 ANTAGONIST 无效用于与IL-6拮抗剂积极预防和治疗牛皮癣
公开(公告)号：EP1334731A4
公开(公告)日：2004-07-28
申请号：EP01978921
申请日：2001-10-25
发明人： ITO HIROAKI , YOSHIZAKI KAZUYUKI , NISHIMOTO NORIHIRO , KISHIMOTO TADAMITSU , SHIMAOKA SHIN , KITAMURA HIDETOMO , SUGIMOTO MASAMICHI , AKAMATSU KENICHI
IPC分类号： A61P17/06 , C07K16/24 , C07K16/28 , A61K45/00 , A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/2866
摘要： Preventives or remedies for psoriasis which contain an interluekin-6 (IL-6) antagonist such as an antibody against IL-6 receptor.
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公开(公告)号：EP2241332A4
公开(公告)日：2011-01-26
申请号：EP08857461
申请日：2008-12-05
IPC分类号： A61K45/00 , A61K39/395 , A61P17/04 , C07K16/28
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/76
摘要： The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
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公开(公告)号：EP1759710A4
公开(公告)日：2009-09-16
申请号：EP05728888
申请日：2005-03-31
发明人： NAKAO KAZUWA , KITAMURA HIDETOMO
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61K45/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P37/02 , A61P43/00
CPC分类号： A61K38/2242
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公开(公告)号：EP1156037A4
公开(公告)日：2002-03-20
申请号：EP00901903
申请日：2000-01-26
发明人： KITAMURA HIDETOMO , KATO ATSUHIKO , ESAKI TORU
IPC分类号： A61K31/404 , A61K31/405 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61P19/08 , C07D209/38 , C07D209/40 , C07D401/06 , C07D403/12 , C07D405/06 , C12N5/02 , A61K31/454 , C07D209/36 , C07D401/12
CPC分类号： C07D401/06 , A61K31/404 , A61K31/405 , A61K31/443 , A61K31/4433 , A61K31/4439 , C07D209/38 , C07D209/40 , C07D403/12 , C07D405/06
摘要： Chondrongenesis promotors characterized by containing as the active ingredient compounds represented by general formula (I) or salts thereof, wherein R1 is halogeno, lower alkyl, lower alkoxy, or the like; R2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, acyl, aryl, a heterocyclic group, or the like; R3 is lower alkyl, cycloalkyl, aryl, a heterocyclic group, or the like; R4 is hydrogen, lower alkyl, aryl, a heterocyclic group, or the like; X and Y are each -CH¿2?-, -NH-, or -O-; and n is an integer of 0 to 4.
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公开(公告)号：EP3153166A4
公开(公告)日：2018-01-17
申请号：EP14894764
申请日：2014-06-09
发明人： NODA HIROSHI , KITAMURA HIDETOMO , TAMURA TATSUYA
IPC分类号： A61K31/435 , A61P19/02 , A61P19/04 , A61P19/08 , A61P19/10
CPC分类号： A61K31/435
摘要： The present invention provides pharmaceutical compositions for inducing bone and/or cartilage anabolism, which comprises as an active ingredient a compound represented by formula (1) below and a pharmacologically acceptable salt thereof: wherein R 1 , R 2 , R 3 , and R 4 are as defined in the claims.
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7.发明公开PREVENTIVE OR REMEDY FOR INFLAMMATORY DISEASE 有权MITTEL ZUR PREVENTION ODER BEHANDLUNG VONENTZÜNDLICHENERKRANKUNGEN
公开(公告)号：EP2047863A4
公开(公告)日：2009-12-09
申请号：EP07744945
申请日：2007-06-08
IPC分类号： A61K45/00 , A61K39/395 , A61P1/04 , A61P1/16 , A61P11/06 , A61P17/02 , A61P19/02 , A61P21/04 , A61P29/00 , A61P37/00 , A61P37/08 , C07K16/28 , C12N15/02
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
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