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公开(公告)号：EP2647707A4
公开(公告)日：2014-04-30
申请号：EP11845786
申请日：2011-11-30
发明人： NEZU JUNICHI , ISHIGURO TAKAHIRO , NARITA ATSUSHI , SAKAMOTO AKIHISA , KAWAI YUMIKO , IGAWA TOMOYUKI , KURAMOCHI TAICHI
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K16/46 , A61K2039/505 , C07K16/2809 , C07K16/2863 , C07K16/30 , C07K16/303 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.
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公开(公告)号：EP3199628A4
公开(公告)日：2018-06-06
申请号：EP15844692
申请日：2015-09-25
发明人： NEZU JUNICHI , NARITA ATSUSHI , ISHIGURO TAKAHIRO , SAKURAI MIKA , SHIRAIWA HIROTAKE , HIRONIWA NAOKA , IGAWA TOMOYUKI , KAWAI YUMIKO
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： C07K16/468 , A61K39/395 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/303 , C07K16/46 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N15/09
摘要： Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.
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