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公开(公告)号：EP2330193A4
公开(公告)日：2012-07-25
申请号：EP09816184
申请日：2009-09-25
发明人： IGAWA TOMOYUKI , ISHII SHINYA , MAEDA ATSUHIKO , SAKURAI MIKA , KOJIMA TETSUO , TACHIBANA TATSUHIKO , SHIRAIWA HIROTAKE , TSUNODA HIROYUKI , HIGUCHI YOSHINOBU
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP3199628A4
公开(公告)日：2018-06-06
申请号：EP15844692
申请日：2015-09-25
发明人： NEZU JUNICHI , NARITA ATSUSHI , ISHIGURO TAKAHIRO , SAKURAI MIKA , SHIRAIWA HIROTAKE , HIRONIWA NAOKA , IGAWA TOMOYUKI , KAWAI YUMIKO
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： C07K16/468 , A61K39/395 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/303 , C07K16/46 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N15/09
摘要： Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.
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3.发明公开ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED ANTIBODY VARIABLE REGION 审中-公开抗原终点MOLEKÜLMIT MODIFIZIERTER VARIABLERANTIKÖRPERREGION
公开(公告)号：EP3070168A4
公开(公告)日：2017-06-28
申请号：EP14859814
申请日：2014-11-11
发明人： IGAWA TOMOYUKI , KADONO SHOJIRO , HIRONIWA NAOKA , SAKURAI MIKA
CPC分类号： C07K16/2809 , C07K16/2848 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2896 , C07K16/30 , C07K16/4283 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2319/00 , C07K2319/70
摘要： The present inventors have successfully prepared an antigen-binding molecule comprising an antibody variable region that has binding activity against a molecule expressed on the surface of a T cell and a molecule expressed on the surface of any other immunocyte, but does not bind to these molecules at the same time. The present invention allows the preparation of an antigen-binding molecule capable of circumventing adverse reactions that may be caused by the cross-linking of T cells to other immunocytes, and provides an antigen-binding molecule suitable as a drug.
摘要翻译： 本发明人成功地制备了包含抗体可变区的抗原结合分子，所述抗体可变区对T细胞表面表达的分子和任何其他免疫细胞表面上表达的分子具有结合活性，但不与这些分子结合 与此同时。 本发明允许制备能够避免可能由T细胞与其他免疫细胞的交联引起的不良反应的抗原结合分子，并提供适合作为药物的抗原结合分子。
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公开(公告)号：EP2206775A4
公开(公告)日：2010-11-03
申请号：EP08833735
申请日：2008-09-26
发明人： IGAWA TOMOYUKI , SAKURAI MIKA , KOJIMA TETSUO , TACHIBANA TATSUHIKO , SHIRAIWA HIROTAKE , TSUNODA HIROYUKI , MAEDA ATSUHIKO
IPC分类号： C12N15/09 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/7155 , G01N2500/04 , G01N2500/10
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