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公开(公告)号：EP4349840A2
公开(公告)日：2024-04-10
申请号：EP24154118.4
申请日：2017-09-26
发明人： YOSHINO, Hitoshi , TSUCHIYA, Satoshi , MATSUO, Atsushi , SATO, Tsutomu , NISHIMOTO, Masahiro , OGURI, Kyoko , OGAWA, Hiroko , NISHIMURA, Yoshikazu , FURUTA, Yoshiyuki , KASHIWAGI, Hirotaka , HORI, Nobuyuki , KAMON, Takuma , SHIRAISHI, Takuya , YOSHIDA, Shoshin , KAWAI, Takahiro , TANIDA, Satoshi , AOKI, Masahide
IPC分类号： C07D519/00
摘要： The present invention provides a a process for manufacturing a compound of formula (Ia), or a pharmaceutically acceptable salt thereof:
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2.发明公开BISPHENYL COMPOUNDS USEFUL AS VITAMIN D SB 3 /SB RECEPTOR AGONISTS 审中-公开ALS维生素D3-REZEPTORAGONISTEN GEEIGNETE BISPHENYLVERBINDUNG
公开(公告)号：EP1740522A2
公开(公告)日：2007-01-10
申请号：EP05727224.7
申请日：2005-03-08
发明人： WALLACE, David , ARRHENIUS, Thomas , RUSSELL, Anna , LIU, Dingguo , XING, Amy , TITH, Sovouthy , HOU, Zheng , TAKAHASHI, Tadakatsu , ONO, Yoshiyuki , KASHIWAGI, Hirotaka , SHIMIZU, Kazuki , IKURA, Hitoshi
CPC分类号： C07D207/26 , C07C57/60 , C07C59/56 , C07C59/68 , C07C59/72 , C07C65/28 , C07C69/712 , C07C69/732 , C07C217/20 , C07C217/34 , C07C229/22 , C07C233/25 , C07C235/20 , C07C317/18 , C07C317/44 , C07C323/16 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/16 , C07D209/32 , C07D211/40 , C07D213/30 , C07D257/04 , C07D307/12 , C07D307/32 , C07D307/33 , C07D307/68 , C07D309/22 , C07D309/30 , C07D317/22 , C07D319/12
摘要： The present invention discloses bisphenyl compounds of the formula (1): wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
摘要翻译： 本发明公开了下式的双苯化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，X，Y，W定义如下。 这些化合物可用作药物。
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公开(公告)号：EP4349840A3
公开(公告)日：2024-07-10
申请号：EP24154118.4
申请日：2017-09-26
发明人： YOSHINO, Hitoshi , TSUCHIYA, Satoshi , MATSUO, Atsushi , SATO, Tsutomu , NISHIMOTO, Masahiro , OGURI, Kyoko , OGAWA, Hiroko , NISHIMURA, Yoshikazu , FURUTA, Yoshiyuki , KASHIWAGI, Hirotaka , HORI, Nobuyuki , KAMON, Takuma , SHIRAISHI, Takuya , YOSHIDA, Shoshin , KAWAI, Takahiro , TANIDA, Satoshi , AOKI, Masahide
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/16 , A61P25/28 , C07D519/00 , C07D413/14
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , C07D519/00 , A61P1/16 , A61P3/06 , A61P3/04 , A61P9/10 , A61P25/16 , A61P25/28 , A61P3/10 , C07D471/04 , Y02A50/30 , C07D413/14
摘要： The present invention provides a a process for manufacturing a compound of formula (Ia), or a pharmaceutically acceptable salt thereof:
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公开(公告)号：EP2975030B1
公开(公告)日：2020-07-15
申请号：EP14765619.3
申请日：2014-03-13
发明人： OHTAKE, Yoshihito , OKAMOTO, Naoki , ONO, Yoshiyuki , KASHIWAGI, Hirotaka , KIMBARA, Atsushi , HARADA, Takeo , HORI, Nobuyuki , MURATA, Yoshihisa , TACHIBANA, Kazutaka , TANAKA, Shota , NOMURA, Kenichi , IDE, Mitsuaki , MIZUGUCHI, Eisaku , ICHIDA, Yasuhiro , OHTOMO, Shuichi , HORIBA, Naoshi
IPC分类号： C07D237/04 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/504 , A61K31/506 , A61K31/5377 , A61P3/12 , A61P13/12 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/18
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5.发明公开
公开(公告)号：EP3192511A1
公开(公告)日：2017-07-19
申请号：EP15839176.3
申请日：2015-09-11
发明人： OHTAKE, Yoshihito , OKAMOTO, Naoki , ONO, Yoshiyuki , KASHIWAGI, Hirotaka , KIMBARA, Atsushi , HARADA, Takeo , HORI, Nobuyuki , MURATA, Yoshihisa , TACHIBANA, Kazutaka , TANAKA, Shota , NOMURA, Kenichi , IDE, Mitsuaki , MIZUGUCHI, Eisaku , ICHIDA, Yasuhiro , OHTOMO, Shuichi , HORIBA, Naoshi
IPC分类号： A61K31/50 , A61K31/19 , A61K31/4545 , A61K31/501 , A61K31/5025 , A61K31/503 , A61K31/506 , A61K31/537 , A61K31/5377 , A61K31/734 , A61K33/08 , A61K33/10 , A61K33/24 , A61K33/26 , A61K45/00 , A61P3/12 , A61P5/18 , A61P9/10 , A61P13/12 , A61P43/00
CPC分类号： A61K31/19 , A61K31/4545 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/503 , A61K31/506 , A61K31/537 , A61K31/5377 , A61K31/734 , A61K33/08 , A61K33/10 , A61K33/24 , A61K33/26 , A61K45/00 , C07D237/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/08
摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a dihydropyridazine-3,5-dione derivative or a salt thereof or a solvate of these.
摘要翻译： 本发明提供含有作为有效成分的二氢哒嗪-3,5-二酮衍生物或其盐或它们的溶剂合物的药物组合物。
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公开(公告)号：EP2975030A1
公开(公告)日：2016-01-20
申请号：EP14765619.3
申请日：2014-03-13
发明人： OHTAKE, Yoshihito , OKAMOTO, Naoki , ONO, Yoshiyuki , KASHIWAGI, Hirotaka , KIMBARA, Atsushi , HARADA, Takeo , HORI, Nobuyuki , MURATA, Yoshihisa , TACHIBANA, Kazutaka , TANAKA, Shota , NOMURA, Kenichi , IDE, Mitsuaki , MIZUGUCHI, Eisaku , ICHIDA, Yasuhiro , OHTOMO, Shuichi , HORIBA, Naoshi
IPC分类号： C07D237/04 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/504 , A61K31/506 , A61K31/5377 , A61P3/12 , A61P13/12 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/18
摘要： The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, and chronic renal failure, comprising the compound as an active ingredient, and a method for prevention and/or treatment.
摘要翻译： 本发明提供二氢哒嗪-3,5-二酮衍生物或其盐或化合物或其盐的溶剂合物，药物药物，药物组合物，钠依赖性磷酸盐转运蛋白抑制剂，以及预防和/ 包含作为活性成分的化合物的高磷酸盐血症，继发性甲状旁腺功能亢进和慢性肾功能衰竭的治疗剂，以及预防和/或治疗的方法。
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公开(公告)号：EP4134367A1
公开(公告)日：2023-02-15
申请号：EP22180270.5
申请日：2017-09-26
发明人： YOSHINO, Hitoshi , TSUCHIYA, Satoshi , MATSUO, Atsushi , SATO, Tsutomu , NISHIMOTO, Masahiro , OGURI, Kyoko , OGAWA, Hiroko , NISHIMURA, Yoshikazu , FURUTA, Yoshiyuki , KASHIWAGI, Hirotaka , HORI, Nobuyuki , KAMON, Takuma , SHIRAISHI, Takuya , YOSHIDA, Shoshin , KAWAI, Takahiro , TANIDA, Satoshi , AOKI, Masahide
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/16 , A61P25/28 , C07D519/00
摘要： The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.
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公开(公告)号：EP3928779A1
公开(公告)日：2021-12-29
申请号：EP21185137.3
申请日：2015-09-11
发明人： OHTAKE, Yoshihito , OKAMOTO, Naoki , ONO,Yoshiyuki , KASHIWAGI, Hirotaka , KIMBARA, Atsushi , HARADA, Takeo , HORI, Nobuyuki , MURATA, Yoshihisa , TACHIBANA, Kazutaka , TANAKA, Shota , NOMURA, Kenichi , IDE, Mitsuaki , MIZUGUCHI, Eisaku , ICHIDA, Yasuhiro , OHTOMO, Shuichi , HORIBA, Naoshi
IPC分类号： A61K31/50
摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a dihydropyridazine-3,5-dione derivative or a salt thereof or a solvate of these, wherein the composition is administered in combination with a phosphorus adsorbent.
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公开(公告)号：EP3517538A1
公开(公告)日：2019-07-31
申请号：EP17853220.6
申请日：2017-09-26
发明人： YOSHINO, Hitoshi , TSUCHIYA, Satoshi , MATSUO, Atsushi , SATO, Tsutomu , NISHIMOTO, Masahiro , OGURI, Kyoko , OGAWA, Hiroko , NISHIMURA, Yoshikazu , FURUTA, Yoshiyuki , KASHIWAGI, Hirotaka , HORI, Nobuyuki , KAMON, Takuma , SHIRAISHI, Takuya , YOSHIDA, Shoshin , KAWAI, Takahiro , TANIDA, Satoshi , AOKI, Masahide
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/16 , A61P25/28 , C07D519/00
摘要： The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.
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