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公开(公告)号：EP1807690A1
公开(公告)日：2007-07-18
申请号：EP04804672.6
申请日：2004-12-03
CPC分类号： G01N15/1434
摘要： The present invention relates to a method for the separation of particles (40, 42) with different sizes, including: - introduction of radiation (30) in a waveguide (20), coupled to a second guide in a coupling area, this radiation entraining all particles towards the coupling area, - separation of the particles as they pass into the coupling area.
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2.发明公开DISPOSITIF DE RENFORCEMENT DE FLUORESCENCE LARGE BANDE A FAIBLES PERTES ET CAPTEUR OPTIQUE BIOLOGIQUE OU CHIMIQUE L'UTILISANT. 审中-公开DEVICE加强同低损耗的宽带荧光这种用法SANTANDER光学生物或化学传感器
公开(公告)号：EP1346203A1
公开(公告)日：2003-09-24
申请号：EP01270761.8
申请日：2001-12-12
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6458 , Y10S435/808
摘要： The invention concerns a device for enhancing fluorescence comprising a support (10) supporting fluorescence enhancing means (11), the fluorescence enhancing means providing a surface for receiving chemical or biological elements to be read by detection of a fluorescence signal emitted by a fluorophore, associated with the chemical or biological elements, under the effect of an excitation light beam. The fluorescence enhancing means (11) consist of a thin transparent dielectric layer or a stack of thin transparent dielectric layers (12 to 16) ensuring a mirror function for the fluorescence signals and for the excitation light beam, the material of the thin layer or of each thin layer of the stack being selected among the following materials: TiO2, Ta2O5, HfO2, ZrO2, MgO, SiO2, Si3N4, MgF2, YF3. The invention is applicable to a biological or chemical optical sensor.
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公开(公告)号：EP1690082B1
公开(公告)日：2007-11-14
申请号：EP04819706.5
申请日：2004-12-03
CPC分类号： B07C5/00
摘要： The present invention relates to a method for sorting particles (100), including: - marking of said particles in order to modifytheir optical index, - placement of the said particles on a waveguide (104) of a support (108), - injection of light radiation into the said waveguide, injection causing displacement of particles on the said waveguide and separation of the particles.
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4.发明公开Biocapteur à substrat quelconque pouvant être caracterisé en deflexion photothermique 审中-公开任何基材的生物传感器，其特征在于光热偏转
公开(公告)号：EP1431747A3
公开(公告)日：2009-11-04
申请号：EP03104760.8
申请日：2003-12-17
CPC分类号： G01N21/171
摘要： L'invention concerne un support d'échantillon destiné à supporter un échantillon devant subir une détection et/ou une analyse par une méthode de détection photothermique mettant en oeuvre un faisceau pompe d'irradiation de l'échantillon et un faisceau sonde de détection et/ou d'analyse. Il comprend un substrat supportant un empilement de couches minces diélectriques formant un miroir de Bragg qui est destiné à supporter l'échantillon, l'empilement de couches minces diélectriques permettant de réfléchir le faisceau pompe qui lui parvient.
L'invention concerne également un dispositif de détection et/ou d'analyse d'un échantillon par une méthode photothermique, ledit dispositif comprenant un support d'échantillon selon l'invention, un moyen d'éclairage de l'échantillon supporté par ledit support et fournissant un faisceau pompe, un moyen de détection et/ou de mesure de l'absorption ou de la réflexion du faisceau pompe par l'échantillon lorsqu'il est éclairé par ledit moyen d'éclairage.
Enfin, l'invention concerne une utilisation particulière dudit dispositif.-
公开(公告)号：EP1690078A1
公开(公告)日：2006-08-16
申请号：EP04804673.4
申请日：2004-12-03
CPC分类号： G01N15/14 , G02B2006/12176 , G02B2006/12183
摘要： The present invention relates to a method for concentrating particles (100) , including: - placement of the said particles (100) close to and/ or on at least one waveguide (108) of a support (104), - injection of light radiation into the said waveguide (108) causing grouping of particles (100) into one or several clusters (106) on the waveguides (108).
摘要翻译： 本发明涉及一种用于浓缩颗粒（100）的方法，包括： - 将所述颗粒（100）放置在靠近和/或在支撑件（104）的至少一个波导（108）上和/或之上， - 光辐射 进入所述波导（108），使得将粒子（100）分组成波导（108）上的一个或多个簇（106）。
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6.发明公开Biocapteur à substrat quelconque pouvant être caracterisé en deflexion photothermique 审中-公开生物传感器ae einem beliebigen Substrat gekennzeichnet durch photothermische Ablenkung
公开(公告)号：EP1431747A2
公开(公告)日：2004-06-23
申请号：EP03104760.8
申请日：2003-12-17
CPC分类号： G01N21/171
摘要： L'invention concerne un support d'échantillon destiné à supporter un échantillon devant subir une détection et/ou une analyse par une méthode de détection photothermique mettant en oeuvre un faisceau pompe d'irradiation de l'échantillon et un faisceau sonde de détection et/ou d'analyse. Il comprend un substrat supportant un empilement de couches minces diélectriques formant un miroir de Bragg qui est destiné à supporter l'échantillon, l'empilement de couches minces diélectriques permettant de réfléchir le faisceau pompe qui lui parvient.
L'invention concerne également un dispositif de détection et/ou d'analyse d'un échantillon par une méthode photothermique, ledit dispositif comprenant un support d'échantillon selon l'invention, un moyen d'éclairage de l'échantillon supporté par ledit support et fournissant un faisceau pompe, un moyen de détection et/ou de mesure de l'absorption ou de la réflexion du faisceau pompe par l'échantillon lorsqu'il est éclairé par ledit moyen d'éclairage.
Enfin, l'invention concerne une utilisation particulière dudit dispositif.摘要翻译： 衬底支持形成布拉格反射镜的薄介电层的堆叠。 这支持一个样本。 堆叠反射入射光束。 最上层包括与样品生物相容的材料，并且具有低折射率。 包括使用上述装置的方法的独立权利要求。 它热分析光，并包括描述的样品支持。 支撑的样品被照亮，并且提供泵送或激发束（1）。 当仪器被照亮时，仪器会检测和/或测量样品对激发光束的吸收或反射。 检测器可以定位。 选择激发光束波长用于样品吸收和/或通过样品标记。
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7.发明公开PROCEDE ET DISPOSITIF DE CONTROLE DU POSITIONNEMENT D UN ELE MENT BIOLOGIQUE SUR UN SUPPORT 审中-公开用于控制在载体上的生物元件的定位方法和装置
公开(公告)号：EP1759200A1
公开(公告)日：2007-03-07
申请号：EP05728107.3
申请日：2005-02-23
IPC分类号： G01N33/487 , C12M1/34
CPC分类号： G01N33/48728
摘要： The invention relates to a method which can be used to control the positioning of a biological element on an area of a support directly and in real time, whereby the biological element is marked with a light-emitting tracer and the area of the support on which it is to be positioned is located in a layer of material that can trap the light. The inventive method comprises the following steps consisting in: a) allowing the biological element to be positioned on the area of the support; b) measuring the intensity of the light trapped in the aforementioned layer; and c) determining the position of the biological element by comparing the intensity value thus measured to at least one reference value. According to the invention, steps a), b) and c) can be performed successively or simultaneously. The invention also relates to a device which enables said method to be used in order to position one or more biological elements on one or more areas of a support.
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公开(公告)号：EP1690082A1
公开(公告)日：2006-08-16
申请号：EP04819706.5
申请日：2004-12-03
CPC分类号： B07C5/00
摘要： The present invention relates to a method for sorting particles (100), including: - marking of said particles in order to modifytheir optical index, - placement of the said particles on a waveguide (104) of a support (108), - injection of light radiation into the said waveguide, injection causing displacement of particles on the said waveguide and separation of the particles.
摘要翻译： 本发明涉及一种用于分选颗粒（100）的方法，包括： - 标记所述颗粒以便修改其光学指数， - 将所述颗粒放置在支撑件（108）的波导（104）上， - 注入 光辐射进入所述波导，注入导致所述波导上的粒子位移和粒子分离。
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9.发明公开SUPPORT DE BIOPUCE UTILISANT DES COUCHES MINCES DE MATERIAU SOL GEL ET PROCEDE DE REALISATION 审中-公开复合式溶胶 - 凝胶材料综合载体生物芯片及其制造方法
公开(公告)号：EP1620729A1
公开(公告)日：2006-02-01
申请号：EP04742650.7
申请日：2004-05-06
IPC分类号： G01N33/543 , B01J19/00 , G02B1/10
CPC分类号： G01N33/54373 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00641 , B01J2219/00644 , B01J2219/00704 , B01J2219/0072 , C03C17/006 , C03C17/009 , C03C17/42 , C03C2217/212 , C03C2217/213 , C03C2217/214 , C03C2217/22 , C03C2217/425 , C03C2218/113
摘要： The invention relates to a biochip support. The inventive support consists of a substrate bearing at least one porous layer of material on a first face, whereby the layer is intended to ensure the fixing of biological molecules on and inside said layer. The support is characterised in that the layer is a thin optical layer of material prepared by sol-gel process, having a refractive index which is less than that of the substrate. The invention also relates to a method of grafting biological molecules to the surface of, and inside the thin layer of material prepared by sol-gel process on the first face of the biochip support. The aforementioned method comprises the following steps: preparation of a sol which is intended to provide the sol-gel material; incorporation of bio-molecules in the material during the preparation thereof; grafting of bio-molecules in the material during the preparation thereof; deposition of a thin layer of said sol on the first face of the substrate; and production of the thin layer of sol-gel material from the thin layer of sol. Moreover, one particular grafting method also comprises a step involving the structuring of the thin layer of sol-gel material in order to produce a network of pits and bumps over all or part of the biochip support.
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10.发明公开SUBSTRAT REVETU D'UN FILM ORGANIQUE TRANSPARENT ET PROCEDE DE FABRICATION 审中-公开随着对HERSTELUNG透明有机膜涂布底材和方法
公开(公告)号：EP1440335A1
公开(公告)日：2004-07-28
申请号：EP02790522.3
申请日：2002-10-16
CPC分类号： H01B3/30 , C09D4/00 , G01N21/6428 , G02B1/04
摘要： The invention concerns a substrate coated with a transparent organic film and a method for making same, and use thereof. The film-coated substrate is characterized in that the film is an electrically insulating organic polymer and transparent in at least a range of wavelengths, and in that the film is associated with a marker emitting at least in said wavelength range. The invention is in particular applicable in a means for detecting a chemical species, such as a biochip, in a quality control process, a certification process or an authentication process for an object.
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