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1.发明公开MICRO-CAPTEURS ET NANO-CAPTEURS D’ESPECES CHIMIQUES ET BIOLOGIQUES A PLASMONS DE SURFACE 审中-公开MIKROSENSOREN UND NANOSENSORENFÜRCHEMISCHE UND BIOLOGISCHE SPEZIES MITOBERFLÄCHENPLASMONEN
公开(公告)号：EP1670951A2
公开(公告)日：2006-06-21
申请号：EP04805737.6
申请日：2004-10-07
IPC分类号： C12Q1/68
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6837 , G01N21/554 , G01N21/648 , G01N2021/258
摘要： The invention relates to a microsensor or nanosensor for chemical or biological species with surface plasmons. The inventive sensor comprises studs (2) which are distributed over the surface of a support (1), said studs (2) measuring less than 1 µm. Moreover, the studs are made from an electrically-conductive material and can immobilise the chemical or biological species.
摘要翻译： 用于化学或生物物种的表面等离子体显微传感器或纳米传感器，包括分布在支撑体表面上的焊盘，所述焊盘包括导电材料并且能够固定化学或生物物质。 焊盘的尺寸小于1μm。
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公开(公告)号：EP1216410B1
公开(公告)日：2009-12-30
申请号：EP00966233.9
申请日：2000-09-29
发明人： VINET, Françoise , CHATON, Patrick
CPC分类号： G01N21/171
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3.发明公开
公开(公告)号：EP1344062A1
公开(公告)日：2003-09-17
申请号：EP01994906.4
申请日：2001-12-19
发明人： CHATON, Patrick , VINET, Françoise
IPC分类号： G01N33/543 , C12Q1/68 , G01N21/64
CPC分类号： G01N33/54393
摘要： The invention concerns an analysis support for determining an analyte such as a target DNA or RNA, by using a specific binding reaction (hybridization) of said analyte with a ligand specific of said analyte, and determining the binding reaction using at least two fluorescent markers present on the analyte. Said determination is carried out by applying an excitation field and by detecting the fluorescent emission of the different fluorescent markers. The invention is characterised in that the support comprises a substrate coated with one or several material layers forming an assembly capable of attenuating or increasing the excitation field for at least one of the fluorescent markers relative to the others. The ligands are fixed on the last layer of the assembly. A SiO2 layer on a silicon substrate can be used with the Cy3 and Cy5 fluorescent markers.
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4.发明公开UTILISATION DE LA TRANSFORMEE DE FOURIER OPTIQUE POUR LE CONTROLE DIMENSIONNEL EN MICROELECTRONIQUE 有权使用合格的光学Fourier变换随着微电子尺寸公差
公开(公告)号：EP1682879A2
公开(公告)日：2006-07-26
申请号：EP04816136.8
申请日：2004-09-17
发明人： PETIT, Jérôme , CHATON, Patrick , GRAND, Gilles , LEROUX, Thierry
IPC分类号： G01N21/956
CPC分类号： G01N21/956 , G01B11/0616 , G01N21/95623
摘要： The invention concerns a device for measuring dimensional or structural characteristics of an object, comprising: means (2) for forming an image of the optical Fourier transform of an elementary surface of the object in the image focal plane; processing means (26) for producing data concerning at least one dimensional and/or structural characteristic of the object based on the data supplied by the detecting means.
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5.发明公开DISPOSITIF DE RENFORCEMENT DE FLUORESCENCE LARGE BANDE A FAIBLES PERTES ET CAPTEUR OPTIQUE BIOLOGIQUE OU CHIMIQUE L'UTILISANT. 审中-公开DEVICE加强同低损耗的宽带荧光这种用法SANTANDER光学生物或化学传感器
公开(公告)号：EP1346203A1
公开(公告)日：2003-09-24
申请号：EP01270761.8
申请日：2001-12-12
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6458 , Y10S435/808
摘要： The invention concerns a device for enhancing fluorescence comprising a support (10) supporting fluorescence enhancing means (11), the fluorescence enhancing means providing a surface for receiving chemical or biological elements to be read by detection of a fluorescence signal emitted by a fluorophore, associated with the chemical or biological elements, under the effect of an excitation light beam. The fluorescence enhancing means (11) consist of a thin transparent dielectric layer or a stack of thin transparent dielectric layers (12 to 16) ensuring a mirror function for the fluorescence signals and for the excitation light beam, the material of the thin layer or of each thin layer of the stack being selected among the following materials: TiO2, Ta2O5, HfO2, ZrO2, MgO, SiO2, Si3N4, MgF2, YF3. The invention is applicable to a biological or chemical optical sensor.
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6.发明公开
公开(公告)号：EP1234170A1
公开(公告)日：2002-08-28
申请号：EP00985381.3
申请日：2000-12-01
CPC分类号： G01N21/6452
摘要： The invention concerns the enhancement of surface-generated fluorescence emitted by a sample. The device (10) comprises a support (11) transmitting all or part of the fluorescence signal and designed to support the surface sample (13), a thin film (12) being inserted between the support (11) and the surface sample (13), the thin film having a refractive index higher than the refractive index of the support and than the refractive index of the medium wherein the surface sample is immersed during the measuring of fluorescence, the thickness of the thin film being selected so that the thin film (12) transmits all or part of the fluorescence signal which is measured after it has passed through the support (11).
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公开(公告)号：EP1216411B1
公开(公告)日：2009-12-30
申请号：EP00966234.7
申请日：2000-09-29
CPC分类号： G01N21/171 , C12Q1/6816 , C12Q2527/101
摘要： The invention concerns a method for detecting without marking a molecular recognition reaction, and a device for implementing said method. The invention concerns the general field of detection and analysis of a molecular recognition between a first molecule and a second molecule, for instance in molecular biology. The inventive method comprises the detection of molecular recognition using a photothermal method, for example a thermal lens microscope.
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8.发明授权
公开(公告)号：EP1344062B1
公开(公告)日：2009-04-08
申请号：EP01994906.4
申请日：2001-12-19
发明人： CHATON, Patrick , VINET, Françoise
IPC分类号： G01N33/543 , C12Q1/68 , G01N21/64
CPC分类号： G01N33/54393
摘要： The invention concerns an analysis support for determining an analyte such as a target DNA or RNA, by using a specific binding reaction (hybridization) of said analyte with a ligand specific of said analyte, and determining the binding reaction using at least two fluorescent markers present on the analyte. Said determination is carried out by applying an excitation field and by detecting the fluorescent emission of the different fluorescent markers. The invention is characterised in that the support comprises a substrate coated with one or several material layers forming an assembly capable of attenuating or increasing the excitation field for at least one of the fluorescent markers relative to the others. The ligands are fixed on the last layer of the assembly. A SiO>2
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公开(公告)号：EP1346260A1
公开(公告)日：2003-09-24
申请号：EP01270808.7
申请日：2001-12-12
CPC分类号： G03F7/20 , B01J2219/00497 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00711 , B82Y30/00 , G03F7/09
摘要： The invention concerns a substrate (1) having a surface for receiving (4) a layer of material to be exposed by an insolation light, characterised in that the means forming mirror (3) are arranged between said reception surface (4) and the material to be exposed, said means forming mirror (3) operating for the wavelength of the insolation light. Such a substrate can be used for producing microelectronic, micro-technology devices or biochips.
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10.发明公开
公开(公告)号：EP1216411A1
公开(公告)日：2002-06-26
申请号：EP00966234.7
申请日：2000-09-29
CPC分类号： G01N21/171 , C12Q1/6816 , C12Q2527/101
摘要： The invention concerns a method for detecting without marking a molecular recognition reaction, and a device for implementing said method. The invention concerns the general field of detection and analysis of a molecular recognition between a first molecule and a second molecule, for instance in molecular biology. The inventive method comprises the detection of molecular recognition using a photothermal method, for example a thermal lens microscope.
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