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    Compounds and methods for the diagnosis and treatment of Babesia microti infection
    2.
    发明公开
    Compounds and methods for the diagnosis and treatment of Babesia microti infection 失效
    Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Babesia microti Infektion

    公开(公告)号：EP0834567A2

    公开(公告)日：1998-04-08

    申请号：EP97117067.5

    申请日：1997-10-01

    申请人： CORIXA CORPORATION

    发明人： Reed, Steven G. ,  Lodes, Michael J. ,  Houghton, Raymond ,  Sleath, Paul R.

    IPC分类号： C12N15/30 ,  C07K14/44 ,  C12N15/62 ,  G01N33/569 ,  C12Q1/68 ,  C07K16/20 ,  A61K39/018

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  Y02A50/401 ,  Y02A50/403

    摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

    摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 所提供的化合物包括含有微生物抗原的至少一个抗原部分和编码这种多肽的DNA序列的多肽。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。

    Compounds and methods for diagnosis of tuberculosis
    8.
    发明公开
    Compounds and methods for diagnosis of tuberculosis 失效
    Verbindungen und Verfahren zur Diagnose von Tuberkulose

    公开(公告)号：EP2154248A1

    公开(公告)日：2010-02-17

    申请号：EP09174756.8

    申请日：1996-08-30

    申请人： CORIXA CORPORATION

    发明人： Reed, Steven ,  Skeiky, Yasir ,  Dillon, Davin ,  Campos-Neto, Antonio ,  Houghton, Raymond ,  Vedvick, Thomas ,  Twardzik, Daniel

    IPC分类号： C12N15/31 ,  C07K14/35 ,  C12N15/62 ,  A61K39/04 ,  G01N33/569

    CPC分类号： C12Q1/689 ,  C07K14/35 ,  G01N33/5695

    摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis secretory or non-secretory proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

    摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌分泌或非分泌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。