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1.发明公开Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use 失效化合物用于免疫治疗和诊断结核病，和使用它们的方法
公开(公告)号：EP2248900A1
公开(公告)日：2010-11-10
申请号：EP10174425.8
申请日：1998-05-20
申请人： CORIXA CORPORATION
IPC分类号： C12N15/31 , C07K14/35 , A61K39/04 , A61K48/00 , A61K49/00 , C12N15/62 , C07K19/00 , G01N33/50 , G01N33/60 , G01N33/569 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/10
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M . Tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M . Tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 抗结核诱导保护性免疫化合物和方法可以游离缺失盘。 所提供的化合物包括多肽也含有一种或多种M的至少一个免疫原性部分 杆菌蛋白和编码检测所述多肽的DNA分子。 搜索化合物可以配制成疫苗和/或药物组合物用于对抗M.免疫 杆菌感染，或可用于结核病的诊断。
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2.发明公开
公开(公告)号：EP1696028A2
公开(公告)日：2006-08-30
申请号：EP06005998.7
申请日：2001-05-22
申请人： CORIXA CORPORATION
发明人： Frudakis, Tony , Reed, Steven , Smith, John , Misher, Lynda , Dillon, Davin , Retter, Marc , Wang, Aijun , Skeiky, Yasir , Harlocker, Susan , Day, Craig
CPC分类号： C07K14/005 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/53 , A61K2039/57 , C07K14/47 , C07K14/82 , C07K2319/00 , C12N2740/10022 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 披露了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 说明性组合物包含一种或多种乳房肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞和对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如诊断，预防和/或治疗疾病，特别是乳腺癌。
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3.发明授权
公开(公告)号：EP2298877B1
公开(公告)日：2014-09-24
申请号：EP10179294.3
申请日：1998-02-25
申请人： Corixa Corporation
发明人： Xu, Jiangchun , Dillon, Davin
IPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/705 , C07K2319/00 , C12N9/90
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4.发明授权Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use 失效化合物用于免疫治疗和诊断结核病，和使用它们的方法
公开(公告)号：EP2248900B1
公开(公告)日：2012-07-18
申请号：EP10174425.8
申请日：1998-05-20
申请人： CORIXA CORPORATION
IPC分类号： C12N15/31 , C07K14/35 , A61K39/04 , A61K48/00 , A61K49/00 , C12N15/62 , C07K19/00 , G01N33/50 , G01N33/60 , G01N33/569 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/10
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
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5.发明公开Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis 失效Leishmanien-Antigene zur Verwendung bei der Therapie und Diagnus von Leishmaniose
公开(公告)号：EP2284186A1
公开(公告)日：2011-02-16
申请号：EP10177490.9
申请日：1998-02-12
申请人： CORIXA CORPORATION
IPC分类号： C07K14/44 , C12N15/30 , A61K39/008 , G01N33/569
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
摘要翻译： 公开了预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供了包含这种多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。
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6.发明公开Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use 失效化合物用于免疫治疗和诊断结核病，和使用它们的方法
公开(公告)号：EP2172551A3
公开(公告)日：2010-11-10
申请号：EP08172265.4
申请日：1998-05-20
申请人： CORIXA CORPORATION
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. Tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. Tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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7.发明公开Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use 失效化合物用于免疫治疗和诊断结核病，和使用它们的方法
公开(公告)号：EP2172551A2
公开(公告)日：2010-04-07
申请号：EP08172265.4
申请日：1998-05-20
申请人： CORIXA CORPORATION
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. Tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. Tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 抗结核诱导保护性免疫化合物和方法可以游离缺失盘。 所提供的化合物包括多肽也含有一种或多种结核分枝杆菌蛋白和编码检测所述多肽的DNA分子中的至少一个免疫原性部分。 搜索化合物可以配制成疫苗和/或药物组合物用于对结核分枝杆菌感染免疫，或可用于结核病的诊断。
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8.发明公开
公开(公告)号：EP2298877A1
公开(公告)日：2011-03-23
申请号：EP10179294.3
申请日：1998-02-25
申请人： Corixa Corporation
发明人： Xu, Jiangchun , Dillon, Davin
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/705 , C07K2319/00 , C12N9/90
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
摘要翻译： 提供了用于治疗前列腺癌的化合物和方法。 本发明的化合物包括多肽至少含有前列腺肿瘤蛋白的一部分。 疫苗和前列腺癌，包括搜索多肽或编码检查的多肽的DNA分子的免疫治疗的药物组合物，所以被提供，连同DNA分子用于制备本发明的多肽。
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公开(公告)号：EP1712628A3
公开(公告)日：2007-05-23
申请号：EP06112509.2
申请日：1996-08-30
申请人： CORIXA CORPORATION
发明人： Reed, Steven , Skeiky, Yasir , Dillon, Davin , Campos-Neto, Antonio , Houghton, Raymond , Vedvick, Thomas , Twardzik, Daniel
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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10.发明公开
公开(公告)号：EP1696028A3
公开(公告)日：2006-12-27
申请号：EP06005998.7
申请日：2001-05-22
申请人： CORIXA CORPORATION
发明人： Frudakis, Tony , Reed, Steven , Smith, John , Misher, Lynda , Dillon, Davin , Retter, Marc , Wang, Aijun , Skeiky, Yasir , Harlocker, Susan , Day, Craig
CPC分类号： C07K14/005 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/53 , A61K2039/57 , C07K14/47 , C07K14/82 , C07K2319/00 , C12N2740/10022 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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