专利检索 ap:("CORNELL RESEARCH FOUNDATION, INC." OR "PURDUE RESEARCH FOUNDATION") AND inv:"LUO, Jianying" 第 1 页

1.

发明授权
HIGH FIDELITY DETECTION OF NUCLEIC ACID DIFFERENCES BY LIGASE DETECTION REACTION 失效
标题翻译： NUCLEIC差异，通过连接酶检测反应的高灵敏度检测

公开(公告)号：EP0956359B1

公开(公告)日：2011-10-26

申请号：EP97936059.1

申请日：1997-07-15

申请人： CORNELL RESEARCH FOUNDATION, INC. , Purdue Research Foundation

发明人： BARANY, Francis , LUO, Jianying , KHANNA, Marilyn , BERGSTROM, Donald, E.

IPC分类号： C12P19/34 , C12Q1/68

CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501

摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.

2.

发明公开
HIGH FIDELITY DETECTION OF NUCLEIC ACID DIFFERENCES BY LIGASE DETECTION REACTION 失效
标题翻译： NUCLEIC差异，通过连接酶检测反应的高灵敏度检测

公开(公告)号：EP0956359A1

公开(公告)日：1999-11-17

申请号：EP97936059.0

申请日：1997-07-15

申请人： CORNELL RESEARCH FOUNDATION, INC. , PURDUE RESEARCH FOUNDATION

发明人： BARANY, Francis , LUO, Jianying , KHANNA, Marilyn , BERGSTROM, Donald, E.

IPC分类号： C12N15 , C07H21 , C07K14 , C12N9 , C12Q1

CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501

摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.