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公开(公告)号:EP1012521A4
公开(公告)日:2002-05-15
申请号:EP98934171
申请日:1998-07-16
IPC分类号: F28F7/00 , A61B18/02 , C09K5/04 , F25B9/00 , F25B9/02 , F28D7/02 , F28D7/12 , F28F13/06 , F28F21/08 , F28D9/00 , F28D17/00 , F28F3/08 , A61B17/36
CPC分类号: C09K5/045 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B9/006 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F28D7/12 , F28F13/06 , F28F21/082 , F28F21/085 , F28F2260/02
摘要: A microminiature laminated heat exchanger for use in a cryogenic probe, and a method of manufacture. The heat exchanger has high and low pressure flow patterns (46, 48) etched into oxygen free copper sheets (42), with the flow patterns being tortuous paths promoting turbulent flow. The sheets (42) containing the flow patterns are bonded into a laminated assembly in the shape of a cylinder (28), with a high pressure inlet and a low pressure outlet in a first end, and a high pressure outlet and a low pressure inlet in a second end. The high pressure flow path lies alongside the low pressure flow path, with flow in the two paths being in opposite directions, to accomplish counterflow heat exchange. Substantial portions of the flow paths are either parallel to, or transverse to, the longitudinal axis of the heat exchanger, with the resuulting heat flow being essentially radial or axial, respectively.
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公开(公告)号:EP0855010A4
公开(公告)日:1999-11-17
申请号:EP96936309
申请日:1996-10-09
申请人: CRYOGEN INC , US COMMERCE
IPC分类号: A61B18/02 , C09K5/04 , F25B9/00 , F25B9/02 , F28D7/12 , F28F13/06 , F28F21/08 , F25B19/02 , A61B17/36 , F25D3/00
CPC分类号: F28F13/06 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K5/045 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B9/006 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F28D7/12 , F28F21/08 , F28F2260/00
摘要: A miniature mixed gas refrigeration system is disclosed, having a coaxial catheter (18) with an inner high pressure supply lumen (24) and an outer low pressure return lumen (22). The gas mixture is pressurized by a compressor (12) to a pressure less than 420 psia, for safety reasons. The distal portion (23) of the outer lumen contains a micro-miniature heat exchanger (28) constructed of laminated plates or sheets (42). The plates or sheets (42) establish high pressure (36) and low pressure passageways (40), with high surface area, having a tortuous path for the gas flow to maximize heat exchange. The high pressure outlet (50) of the heat exchanger (28) is connected to a Joule-Thomson expansion element (30) where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 180K. This low temperature gas cools a heat transfer element (32) mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the heat exchanger to pre-cool the incoming high pressure gas mixture.
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公开(公告)号:EP0929779A4
公开(公告)日:2000-01-19
申请号:EP97910818
申请日:1997-10-07
申请人: CRYOGEN INC
发明人: DOBAK JOHN D III , BROWN TERRY L , GHAERZADEH KAMBIZ , YU XIAOYU
IPC分类号: F25D3/10 , A61B18/02 , C09K5/04 , F25B7/00 , F25B9/00 , F25B9/02 , F25B19/02 , A61B17/36 , F25D3/00
CPC分类号: F25B9/006 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K5/045 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B7/00 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12
摘要: A miniature mixed gas refrigeration system and method is disclosed. A selected gas mixture is compressed to less than 420 psia for safety reasons. The compressed gas mixture is passed through a primary heat exchanger (140) and a primary/secondary heat exchanger (240) to precool the gas mixture. The secondary side of the primary/secondary heat exchanger is cooled by a secondary Joule-Thomson refrigeration system (200). Flow restrictions in the primary side of the primary/secondary heat exchanger (240) can solidify and trap liquid contaminants. The gas mixture exiting the primary outlet of the primary/secondary heat exchanger (240) passes to a primary expansion element (150) to expand isenthalpically to a to 183K or below to cool a heat transfer element. Return gas through the primary heat exchanger (140) precools the incoming high pressure gas mixture. A distal primary heat exchanger (160) can be added between the primary/secondary heat exchanger (240) and the primary expansion element (150).
摘要翻译: 公开了一种微型混合气体制冷系统和方法。 出于安全原因,选定的气体混合物被压缩到小于420psia。 压缩的气体混合物通过主换热器(140)和主/次换热器(240)以预冷气体混合物。 主/辅热交换器的二次侧由二级焦耳 - 汤姆逊制冷系统(200)冷却。 初级/次级热交换器(240)的初级侧的流量限制可固化并截留液体污染物。 离开主/辅热交换器(240)的主出口的气体混合物传送至主膨胀元件(150),以等焓膨胀至183K或更低以冷却热传递元件。 通过主换热器(140)的返回气体预冷进入的高压气体混合物。 可以在主/辅热交换器(240)和主膨胀元件(150)之间添加远端主热交换器(160)。
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公开(公告)号:EP0981292A4
公开(公告)日:2000-04-19
申请号:EP97954809
申请日:1997-12-19
申请人: CRYOGEN INC
发明人: DOBAK JOHN D III , GHAERZADEH KAMBIZ , YU XIAOYU
IPC分类号: A61B19/02 , A61B17/00 , A61B17/42 , A61B18/00 , A61B18/02 , A61B18/24 , A61B19/00 , A61B1/00
CPC分类号: A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要: This invention is a disposable, sterilized sheath (20) for use on a closed loop Joule-Thomson cryosurgical probe (10), the combination of the disposable sheath (20), and the probe (10). The sheath (20) is slipped over the probe (10), thereby separating the probe (10) from the environment. The sheath has a grip (22) which fits over the handle (12) of the probe (10), and an extendible shroud (23) that can be longitudinally extended to cover tubing (18) which is attached to the handle (12). The sheath (20) has a hollow multi-lumen catheter (24) shaped and sized to fit snugly over the cannula (14) of the probe (10). The catheter (24) is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations. A thermally conductive cap or tip (26) fits snugly over the cold tip (16) on the probe (12) and it efficiently transfers heat from the target tissue to the cold tip (16), which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter (24) or conductive tip (16), such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing illumination or laser system. Connections between the instrumentation near the distal end of the catheter (24) and the probe (10) are made via a plurality of lumens passing longitudinally through the wall of the catheter (24).
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公开(公告)号:EP1086341A4
公开(公告)日:2005-07-06
申请号:EP99921787
申请日:1999-05-06
申请人: CRYOGEN INC
发明人: DOBAK JOHN D III , BROWN TERRY L , GHAERZADEH KAMBIZ , YU XIAOYU
CPC分类号: C09K5/045 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/22 , F25B7/00 , F25B9/006 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12
摘要: A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor (130) to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger (240), to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger (240) is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element (150) where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter of cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger (160) to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger (140) can be added between the primary-to-secondary heat exchanger (240) and the primary compressor (130).
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公开(公告)号:EP1210000A4
公开(公告)日:2004-08-04
申请号:EP00959145
申请日:2000-08-24
申请人: CRYOGEN INC
CPC分类号: A61B18/02 , A61B1/00142 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2218/002
摘要: A sheath (20) for use on a closed loop Joule-Thomson cryosurgical probe (10), and the combination of the sheath (20) and the closed loop probe (10). The sheath (20) is slipped over the probe (10), thereby separating the probe from the environment. The sheath (20) has a grip (22) which fits over the handle (12) of the cryosurgical probe, and an extendible shroud (23) which can be longitudinally extended to cover tubing (18) and which are attached to the handle (12). The sheath (20) has a hollow multi-lumen catheter (24) shaped and sized to fit snugly over the cannula (14) of the cryosurgical probe (10). The catheter (24) is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip (26) is biased against the cold tip (16) on the probe (10) by a biasing element (28) in the sheath assembly.
摘要翻译: 用于闭环Joule-Thomson冷冻外科探针(10)的鞘(20)以及鞘(20)和闭环探针(10)的组合。 鞘(20)滑过探针(10),从而将探针与环境分开。 护套20具有配合在冷冻手术探针的手柄12上的手柄22和可纵向延伸以覆盖管18并且附接到手柄18的可延伸护罩23。 12)。 护套(20)具有空心多腔导管(24),其形状和尺寸适合紧贴在冷冻手术探针(10)的套管(14)上。 导管(24)不导热,防止来自周围环境的热量传递至气体混合物,并且防止组织沿着导管在不期望的位置处冻结。 通过护套组件中的偏置元件(28)将导热帽或尖端(26)偏压在探针(10)上的冷尖端(16)上。
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