公开(公告)号：EP2008210A1

公开(公告)日：2008-12-31

申请号：EP06727316.9

申请日：2006-03-15

申请人： CSIR ,  Kenyon, Colin Peter ,  Oldfield, Lyndon Carey ,  Van Der Westhuyzen, Christiaan, Wynand ,  Rousseau, Amanda, Loiuse ,  Parkinson, Christopher, John

发明人： KENYON, Colin, Peter ,  OLDFIELD, Lyndon, Carey ,  VAN DER WESTHUYZEN, Christiaan, Wynand ,  ROUSSEAU, Amanda, Louise ,  PARKINSON, Christopher, John

IPC分类号： G06F19/00 ,  G01N33/68 ,  G01N33/573 ,  C12Q1/48 ,  C07D239/02 ,  C07D239/04 ,  C07D473/00 ,  C07D235/04 ,  C07D239/10 ,  C07D241/40 ,  C07D475/00 ,  C07D487/02 ,  C07D487/14

CPC分类号： C12Q1/485 ,  C07D235/04 ,  C07D239/02 ,  C07D239/04 ,  C07D239/10 ,  C07D239/22 ,  C07D239/48 ,  C07D239/50 ,  C07D241/40 ,  C07D241/44 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D473/34 ,  C07D475/02 ,  C07D475/04 ,  C07D487/14 ,  G01N33/573 ,  G01N2333/9125 ,  Y02A50/52 ,  Y02A50/59 ,  Y02A90/26

摘要： Methods of screening and designing compounds as inhibitors of glutamine synthetase, including adenylylated glutamine synthetase, are provided herein. Compounds and compositions useful for the treatment, prevention, and/or amelioration of bacterial infections, including Mycobacterium tuberculosis, are also provided.

公开(公告)号：EP2464353A1

公开(公告)日：2012-06-20

申请号：EP10748152.5

申请日：2010-08-06

申请人： CSIR

发明人： ROUSSEAU, Amanda, Louise ,  GRAVESTOCK, David ,  LOURENS, Anna, Catharina Uys

IPC分类号： A61K31/53 ,  C07D251/00 ,  A61P33/06

CPC分类号： A61K31/53 ,  C07C279/26 ,  C07D251/18 ,  Y02A50/411

摘要： The invention provides compounds of formula (I), in which R1 and R2 are independently selected from H, alkyl, aryl and heteroaryl, or R1 and R2 together form a C5-C7 ring, R3-R7 are independently selected from H, halogen, alkyl and alkoxy, X is (CH2)n in which n is 0-5, Y is selected from CH2, NR8, O or S in which R8 is H or alkyl, salts thereof and stereoisomers thereof, for the prophylaxis or treatment of malaria.

公开(公告)号：EP2464353B1

公开(公告)日：2017-03-29

申请号：EP10748152.5

申请日：2010-08-06

申请人： CSIR

发明人： ROUSSEAU, Amanda, Louise ,  GRAVESTOCK, David ,  LOURENS, Anna, Catharina Uys

IPC分类号： A61K31/53 ,  C07D251/00 ,  A61P33/06

CPC分类号： A61K31/53 ,  C07C279/26 ,  C07D251/18 ,  Y02A50/411

摘要： The invention provides compounds of formula (I), in which R1 and R2 are independently selected from H, alkyl, aryl and heteroaryl, or R1 and R2 together form a C5-C7 ring, R3-R7 are independently selected from H, halogen, alkyl and alkoxy, X is (CH2)n in which n is 0-5, Y is selected from CH2, NR8, O or S in which R8 is H or alkyl, salts thereof and stereoisomers thereof, for the prophylaxis or treatment of malaria.

摘要翻译： 本发明提供式（I）化合物，其中R 1和R 2独立地选自H，烷基，芳基和杂芳基，或者R 1和R 2一起形成C 5 -C 7环，R 3 -R 7独立地选自H，卤素， 烷基和烷氧基，X是（CH 2）n，其中n是0-5，Y选自其中R 8是H或烷基的CH 2，NR 8，O或S，其盐和其立体异构体，用于预防或治疗疟疾 。

公开(公告)号：EP2334675B1

公开(公告)日：2014-03-26

申请号：EP09787196.6

申请日：2009-09-15

申请人： CSIR

发明人： BODE, Moira, Leanne ,  ROUSSEAU, Amanda, Louise ,  GRAVESTOCK, David ,  MOLEELE, Simon, Sana ,  VAN DER WESTHUYZEN, Christiaan, Wynand

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61P31/18

CPC分类号： C07D471/04 ,  C07D487/04

公开(公告)号：EP2334675A1

公开(公告)日：2011-06-22

申请号：EP09787196.6

申请日：2009-09-15

申请人： CSIR

发明人： BODE, Moira, Leanne ,  ROUSSEAU, Amanda, Louise ,  GRAVESTOCK, David ,  MOLEELE, Simon, Sana ,  VAN DER WESTHUYZEN, Christiaan, Wynand

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61P31/18

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The invention provides compounds of formula A or B which are useful in the treatment of a subject infected with HIV.