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公开(公告)号：EP3400964A1
公开(公告)日：2018-11-14
申请号：EP17736173.0
申请日：2017-01-09
Applicant: CTC Bio, Inc.
Inventor： JEON, Hong Ryeol , LEE, Bong-Sang , PARK, Su-Jun , HAN, Jiyeong , KIL, Myeongcheol , KIM, Min Seop , MEANG, Seul Ki
IPC: A61K47/30 , A61K9/00 , A61K31/498 , A61K31/4985
CPC classification number: A61K31/55 , A61K9/10 , A61K9/1629 , A61K9/2022 , A61K9/7007 , A61K47/30
Abstract: The present disclosure relates to a pharmaceutical preparation having varenicline or a pharmaceutically acceptable salt thereof as an active ingredient. More particularly, it relates to an orally administered pharmaceutical preparation which allows limited use of a sweetening agent or a flavoring agent by effectively masking the unique taste of varenicline, particularly bitterness, which is a bitter and burning taste, and ensures convenience in taking the pharmaceutical preparation by being orally administrable without irritation, while containing a pharmaceutically effective amount of varenicline or a pharmaceutically acceptable salt thereof, and a method for preparing the same.
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2.发明公开PHARMACEUTICAL PREPARATION CONTAINING ENTECAVIR AS ACTIVE INGREDIENT, AND PREPARATION METHOD THEREFOR 审中-公开含有恩替卡韦作为活性成分的药物制剂及其制备方法
公开(公告)号：EP3158998A1
公开(公告)日：2017-04-26
申请号：EP15809251.0
申请日：2015-06-22
Applicant: CTC Bio, Inc.
Inventor： JEON, Hong Ryeol , KWON, Do-Woo , LEE, Bong-Sang , PARK, Su-Jun , HAN, Jiyeong , KIL, Myeongcheol , KIM, Min Seop
IPC: A61K31/522 , A61K47/06 , A61K31/215 , A61K31/05 , A61P31/00
CPC classification number: A61K31/522 , A61K9/006 , A61K31/05 , A61K31/215 , A61K47/06 , A61K47/10
Abstract: The present invention relates to a pharmaceutical preparation comprising entecavir as an active ingredient, wherein an antioxidizing agent is added to enhance stability of entecavir, and a method for preparing the same. According to the present invention, the invention has an effect that entecavir can be stably maintained in a pharmaceutical preparation containing a certain amount or more of moisture by adding the antioxidizing agent, thereby a pharmaceutical preparation can be provided as a formulation containing a certain amount or more of moisture, for example, an orally disintegrating film formulation.
Abstract translation: 本发明涉及包含恩替卡韦作为活性成分的药物制剂及其制备方法，其中加入抗氧化剂以增强恩替卡韦的稳定性。 根据本发明，通过添加抗氧化剂，可以将恩替卡韦稳定地维持在含有一定量以上的水分的药物制剂中，从而可以以含有一定量的制剂的形式提供药物制剂，或者， 更多的水分，例如口腔崩解膜制剂。
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3.发明公开TADALAFIL FREE BASE-CONTAINING FILM DOSAGE FORM CONTAINING POLYETHYLENE GLYCOL-BASED POLYMER AND/OR VINYL PYRROLIDONE-BASED POLYMER AS DISPERSION STABILIZER 审中-公开不含基于聚乙二醇的聚合物和/或乙烯基吡咯烷酮聚合物作为分散稳定剂的无塔底涂料膜剂型
公开(公告)号：EP2985020A1
公开(公告)日：2016-02-17
申请号：EP14782874.3
申请日：2014-04-11
Applicant: CTC Bio, Inc.
Inventor： JEON, Hong Ryeol , KWON, Do-Woo , LEE, Bong-Sang , PARK, Su-Jun , CHA, Bong-Geun , KIM, Jun-Ki , HAN, Jiyeong , KIL, Myeongcheol
CPC classification number: A61K31/4985 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38
Abstract: The present disclosure relates to a film formulation for oral administration, containing tadalafil free base and a method of preparing the same, and a film may be provided with maximized dispersion stability of tadalafil free base in the film by the addition of a dispersion stabilizing agent in small amounts without unique fragrance or favor that may appear when other dispersion stabilizing agents known in the art are used, and an extremely low likelihood that a reagglomeration phenomenon of tadalafil free base particles will occur, and an amount of bubbles generated may be significantly reduced during a production process.
Abstract translation: 本发明涉及一种含有他达拉非游离碱的口服给药用膜制剂及其制备方法，并且可以通过在膜中添加分散稳定剂而使膜中的他达拉非游离碱具有最大的分散稳定性 当使用本领域中已知的其他分散稳定剂时可能出现的少量没有独特香味或偏爱的特征，以及极低可能性发生他达拉非游离碱颗粒的再聚集现象，并且在产生气泡的量可能显着减少 一个生产过程。
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4.发明公开PHARMACEUTICAL PREPARATION FOR MASKED TASTE ORAL ADMINISTRATION, CONTAINING CLOMIPRAMINE 审中-公开药用植物精油麻醉品CLOMIPRAMIN ZUR ORALEN VERABREICHUNG MIT MASKIERTEM GESCHMACK
公开(公告)号：EP3141264A1
公开(公告)日：2017-03-15
申请号：EP15789641.6
申请日：2015-05-08
Applicant: CTC Bio, Inc.
Inventor： JEON, Hong Ryeol , KWON, Do-Woo , LEE, Bong-Sang , PARK, Su-Jun , HAN, Jiyeong , KIL, Myeongcheol , KIM, Min Seop
CPC classification number: A61K31/55 , A61K9/0053 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/205 , A61K9/7007 , A61K47/32 , A61K47/36
Abstract: The present invention relates to a pharmaceutical preparation for oral administration comprising, as an active ingredient, clomipramine or a pharmaceutically acceptable salt thereof; and a cation exchange resin and an anion polymer as a taste masking agent, wherein the pharmaceutical preparation can be orally administered even while comprising a pharmaceutically effective amount of clomipramine because the unique tastes of clomipramine, particularly, all of the bitter taste, spicy taste and burning taste are effectively masked, and thus the convenience of drug intake and portability is improved, and a method for manufacturing thereof
Abstract translation: 本发明涉及一种口服药物制剂，其包含作为活性成分的氯米帕明或其药学上可接受的盐; 阳离子交换树脂和阴离子聚合物作为掩蔽剂，其中即使包含药物有效量的氯米帕明也可口服给药，因为氯米帕明的独特口味，特别是所有的苦味，辛辣味和 燃烧味道被有效地掩蔽，从而提高了药物摄取和便携性的便利性及其制造方法
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