公开(公告)号：EP1549951A4

公开(公告)日：2006-08-09

申请号：EP03739026

申请日：2003-05-30

申请人： CURAGEN CORP

发明人： ALVAREZ ENRIQUE ,  ANDERSON DAVID W ,  DHANABAL MOHANRAJ ,  KHRAMTSOV NIKOLAI V ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI S ,  LI LI ,  OOI CHEAN ENG ,  PADIGARU MURALIDHARA ,  SHIMKETS RICHARD A ,  ZHONG MEI

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K19/00 ,  C12N5/06 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/62 ,  A61K38/16

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： The proteins of the invention are a family used to modulate the activity of cells and their ability to attract blood vessels. The proteins are used to inhibit angiogenesis, inhibit cell migration, and inhibit actin filament formation. These proteins are used in this context to diagnose and treat proliferative disorders such as cancer.

公开(公告)号：EP1401855A4

公开(公告)日：2004-12-22

申请号：EP02746584

申请日：2002-06-17

申请人： CURAGEN CORP

发明人： SHIMKETS RICHARD A ,  JEFFERS MICHAEL E ,  PRAYAGA SUDHIRDAS K ,  BOLDOG FERENC L ,  YANG MEIJIA ,  BURGESS CATHERINE E ,  FERNANDES ELMA R ,  HERRMANN JOHN L ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI S ,  GORMAN LINDA ,  ZHONG MEI ,  PADIGARU MURALIDHARA ,  PENA CAROL E A ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  RIEGER DANIEL K ,  GROSSE WILLIAM M

IPC分类号： G01N33/50 ,  A61K38/27 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/00 ,  A61P9/00 ,  A61P17/02 ,  A61P17/14 ,  A61P35/00 ,  C07K14/50 ,  C07K16/22 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K31/713 ,  A61K38/18 ,  C07K16/18 ,  C12N15/12

CPC分类号： C07K14/50

公开(公告)号：EP1957115A4

公开(公告)日：2010-02-10

申请号：EP06827784

申请日：2006-11-13

申请人： CURAGEN CORP

发明人： TSE KAM FAI ,  POLLACK VINCENT A ,  MACDOUGALL JOHN ,  SHENOY SURESH G ,  MANSFIELD TRACI ,  LICHENSTEIN HENRI ,  JEFFERS MICHAEL E ,  LAROCHELLE WILLIAM J

IPC分类号： A61K51/00 ,  A61K39/395 ,  C07K16/46 ,  G01N33/53

CPC分类号： C07K16/18 ,  A61K47/48469 ,  A61K47/48561 ,  A61K47/48607 ,  A61K47/48638 ,  A61K47/48746 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6861 ,  A61K47/6869 ,  A61K47/6897 ,  A61K51/1027 ,  A61K51/106 ,  A61K51/1072 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/3038 ,  C07K16/3069 ,  C07K16/42 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/57449 ,  G01N2333/705

摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 though FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

公开(公告)号：EP1549343A4

公开(公告)日：2006-03-15

申请号：EP03754734

申请日：2003-09-16

申请人： ABGENIX INC ,  CURAGEN CORP

发明人： FLOEGE JUERGEN ,  GAZIT-BORNSTEIN GADI ,  KEYT BRUCE ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI

IPC分类号： C07K16/22 ,  G01N33/68 ,  A61K39/395 ,  A61K39/44 ,  A61P13/12 ,  G01N33/53 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535

CPC分类号： G01N33/6893 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/73 ,  G01N2333/49 ,  G01N2800/347