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1.发明公开TASTE-MASKED FORMULATIONS CONTAINING SERTRALINE AND SULFOALKYL ETHER CYCLODEXTRIN 审中-公开TASTE HIDDEN制剂舍曲林和磺烷基醚环糊精
公开(公告)号：EP1742535A4
公开(公告)日：2008-10-15
申请号：EP05804782
申请日：2005-04-19
发明人： MOSHER GEROLD L , GAYED ATEF A , WEDEL REBECCA L
IPC分类号： A01N43/04 , A61K31/137 , A61K31/715 , A61K31/724
CPC分类号： A61K31/715 , A61K9/0095 , A61K31/137 , A61K31/724 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
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2.发明公开INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID 审中-公开磺烷基醚环糊精和皮质类固醇物质含有吸入制剂
公开(公告)号：EP2043599A4
公开(公告)日：2011-06-29
申请号：EP06850326
申请日：2006-12-19
CPC分类号： A61K47/61 , A61K9/0078 , A61K31/573 , A61K31/58 , A61K31/724 , A61K45/06 , A61K47/40 , A61K47/48092 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16 , A61K2300/00
摘要： An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
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3.发明公开FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE 审中-公开制剂氯吡格雷和磺烷基醚环糊精及其使用方法
公开(公告)号：EP2152078A4
公开(公告)日：2011-06-15
申请号：EP08769199
申请日：2008-04-26
发明人： MOSHER GEROLD L , WEDEL REBECCA L , JOHNSON KAREN T , MACHATHA STEPHEN G , COWEE JANE A , CUSHING DANIEL J
IPC分类号： A61K31/4365 , A01N43/42 , A61K31/44 , A61K31/724 , A61K31/727 , A61K45/06 , A61K47/40 , A61K47/48
CPC分类号： A61K47/48969 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4365 , A61K31/44 , A61K31/724 , A61K31/727 , A61K31/737 , A61K45/06 , A61K47/40 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
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4.发明公开
公开(公告)号：EP1945228A4
公开(公告)日：2010-04-07
申请号：EP05856927
申请日：2005-10-26
IPC分类号： A61K31/724 , A61K31/715
CPC分类号： C08B37/0012 , A61K9/0056 , A61K9/0075 , A61K9/0095 , A61K9/1652 , A61K9/205 , A61K9/2054 , A61K31/519 , A61K31/53 , A61K31/5415 , A61K31/573 , A61K31/715 , A61K31/724 , A61K45/06 , A61K47/40 , B01D1/18 , Y10T428/2982
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