公开(公告)号：EP2421828A2

公开(公告)日：2012-02-29

申请号：EP10747951.1

申请日：2010-04-22

Applicant: Cadila Healthcare Limited

Inventor： THOMBARE, Pravain ,  DESAI, Jigar ,  JAIN, Mukul, R.

IPC: C07D211/60 ,  C07D405/12 ,  A61K31/4468 ,  A61P9/04 ,  A61P9/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12

CPC classification number: C07D211/60 ,  C07D405/12

Abstract: The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

公开(公告)号：EP3030561B1

公开(公告)日：2017-01-11

申请号：EP14793899.7

申请日：2014-08-06

Applicant: Cadila Healthcare Limited

Inventor： DESAI, Ranjit, C. ,  DESAI, Jigar ,  PATEL, Pankaj

IPC: C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/08 ,  C07D401/12 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/056 ,  C07D491/107 ,  C07D495/08

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/08 ,  C07D498/08 ,  C07D513/08

公开(公告)号：EP3030561A1

公开(公告)日：2016-06-15

申请号：EP14793899.7

申请日：2014-08-06

Applicant: Cadila Healthcare Limited

Inventor： DESAI, Ranjit, C. ,  DESAI, Jigar ,  PATEL, Pankaj

IPC: C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/08 ,  C07D401/12 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/056 ,  C07D491/107 ,  C07D495/08

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/056 ,  C07D491/08 ,  C07D491/107 ,  C07D495/08 ,  C07D498/08 ,  C07D513/08

Abstract: The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound of the invention inhibits JAK1 and/or JAK2 and/or JAK3 sub families. The present invention also provides methods for the production of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, their tautomeric forms, and their pharmaceutically acceptable salts.

公开(公告)号：EP2205559A1

公开(公告)日：2010-07-14

申请号：EP08869311.4

申请日：2008-10-13

Applicant: Cadila Healthcare Limited

Inventor： DESAI, Jigar ,  THOMBARE, Pravin, S. ,  JAIN, Mukul, R. ,  PATEL, Pankaj, Ramanbhai

IPC: C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/16 ,  C07D211/22 ,  C07D213/64 ,  C07D215/08 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/26 ,  C07D217/06 ,  C07D265/36 ,  C07D401/06 ,  C07D403/04 ,  C07D295/185 ,  A61K31/4709 ,  A61P9/00

CPC classification number: C07D215/08 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/16 ,  C07D211/22 ,  C07D213/64 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/26 ,  C07D217/06 ,  C07D265/36 ,  C07D295/185 ,  C07D401/06 ,  C07D403/04

Abstract: The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

公开(公告)号：EP3481809A1

公开(公告)日：2019-05-15

申请号：EP17751474.2

申请日：2017-07-13

Applicant: Cadila Healthcare Limited

Inventor： DESAI, Ranjit ,  KUMAR, Sanjay S. ,  PANDYA, Vrajesh ,  DESAI, Jigar ,  RAVAL, Saurin

IPC: C07D263/56 ,  C07D413/04 ,  C07D413/12 ,  C07D263/32 ,  C07D271/06 ,  A61K31/4245 ,  A61K31/421 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/497 ,  A61P29/00 ,  A61P37/00