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公开(公告)号：EP1994138B1
公开(公告)日：2014-04-30
申请号：EP07736565.8
申请日：2007-03-05
IPC分类号： C07K14/535 , C12N1/20 , C12N15/68
CPC分类号： C07K14/535 , C12N1/20
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2.发明授权
公开(公告)号：EP2201120B1
公开(公告)日：2013-12-25
申请号：EP08852235.4
申请日：2008-09-22
发明人： MENDIRETTA, Sanjeev, Kumar , PATEL, Pankaj, R. , BANDYOPADHYAY, Sanjay , SARASWAT, Vibhor , SINGH, Arun, Kumar
IPC分类号： C12N15/62
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
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公开(公告)号：EP2935221A1
公开(公告)日：2015-10-28
申请号：EP13828997.0
申请日：2013-12-23
IPC分类号： C07D215/58 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4704 , A61K31/4709 , A61K31/4985 , A61K31/519 , C07D215/60 , C07D401/04 , C07D401/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07D491/04
CPC分类号： C07D471/04 , A61K31/4704 , C07D215/58 , C07D215/60 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/12 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to novel compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及参与其制备的中间体 。
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公开(公告)号：EP2935221B1
公开(公告)日：2018-02-07
申请号：EP13828997.0
申请日：2013-12-23
IPC分类号： C07D215/58 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4704 , A61K31/4709 , A61K31/4985 , A61K31/519 , C07D215/60 , C07D401/04 , C07D401/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07D491/04
CPC分类号： C07D471/04 , A61K31/4704 , C07D215/58 , C07D215/60 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/12 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to novel compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
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5.发明公开
公开(公告)号：EP2201120A2
公开(公告)日：2010-06-30
申请号：EP08852235.4
申请日：2008-09-22
发明人： MENDIRETTA, Sanjeev, Kumar , PATEL, Pankaj, R. , BANDYOPADHYAY, Sanjay , SARASWAT, Vibhor , SINGH, Arun, Kumar
IPC分类号： C12N15/62
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
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6.发明授权
公开(公告)号：EP2459554B1
公开(公告)日：2013-09-18
申请号：EP10779053.7
申请日：2010-07-22
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/427 , A61P3/10
CPC分类号： C07D417/14 , C07D413/12 , C07D413/14
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7.发明公开
公开(公告)号：EP2459554A2
公开(公告)日：2012-06-06
申请号：EP10779053.7
申请日：2010-07-22
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/427 , A61P3/10
CPC分类号： C07D417/14 , C07D413/12 , C07D413/14
摘要： The present invention relates to substituted benzamide derivatives of the general Formula I and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, metabolites, and polymorphs and can be useful for treating disease states mediated by glucokinase. Compounds disclosed herein can be used for reducing blood glucose levels and for increasing insulin secretion for treating type II diabetes. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds, and their use.
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公开(公告)号：EP1994138A2
公开(公告)日：2008-11-26
申请号：EP07736565.8
申请日：2007-03-05
IPC分类号： C12N1/00
CPC分类号： C07K14/535 , C12N1/20
摘要： The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
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